Publications by authors named "Xiaotian Cui"
Background: There is ongoing debate about the safety and efficacy of epicutaneous immunotherapy (EPIT) in treating food allergies. The systematic review and meta-analysis aimed to evaluate the safety and efficacy of EPIT.
Methods: We systematically searched international trial registers (ClinicalTrials.
Article Synopsis
- This study investigates how LncRNA-CIR6 influences the differentiation of mesenchymal stem cells (MSCs) into heart cells in both lab (in vitro) and live mouse models (in vivo).
- Through various techniques like transfection and injections into mice, researchers find that LncRNA-CIR6 significantly boosts the conversion of bone marrow-derived MSCs and human umbilical cord MSCs into cardiogenic cells.
- The results demonstrate that LncRNA-CIR6 not only enhances heart function after damage but also works through the CDK1 protein, helping repair injured heart tissue.
Article Synopsis
- A study using isolated rat atrial perfusion and DPP-4-/- mice aimed to explore how liraglutide, a GLP-1 analog, affects atrial natriuretic peptide (ANP) secretion and atrial dynamics.
- Findings showed that liraglutide significantly decreased ANP levels and pulse pressure in both ex vivo and in vivo models, while blocking GLP-1 receptors with Exendin9-39 reversed these effects.
- The research also highlighted the role of the PI3K/AKT/mTOR signaling pathway in liraglutide's inhibition of ANP secretion, with additional implications involving the expression of Piezo 1 and cathepsin K.
Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.
Proc Natl Acad Sci U S A
March 2022
Identifying inhibitors of pathogenic proteins is the major strategy of targeted drug discoveries. This strategy meets challenges in targeting neurodegenerative disorders such as Huntington’s disease (HD), which is mainly caused by the mutant huntingtin protein (mHTT), an “undruggable” pathogenic protein with unknown functions. We hypothesized that some of the chemical binders of mHTT may change its conformation and/or stability to suppress its downstream toxicity, functioning similarly to an “inhibitor” under a broader definition.
View Article and Find Full Text PDFAim: The accumulation of disease-causing proteins is a common hallmark of many neurodegenerative disorders. Measuring the degradation of such proteins using high-throughput-compatible assays is highly desired for the identification of genetic and chemical modulators of degradation. For example, Huntington's disease (HD) is an incurable hereditary neurodegenerative disorder caused by the cytotoxicity of mutant huntingtin protein (mHTT).
View Article and Find Full Text PDFHuntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with an expanded polyQ stretch. While Htt is ubiquitously expressed, HD is characterized by selective neurodegeneration of the striatum.
View Article and Find Full Text PDFTime-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology is a widely used immunoassay that enables high-throughput quantitative measurements of proteins of interest. One of the well established examples is the TR-FRET assay for mutant huntingtin protein (HTT), which is the major cause of the neurodegenerative Huntington's disease (HD). To measure the mutant HTT protein, the published assays utilize a polyQ antibody, MW1, paired with HTT N-terminal antibodies.
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