Publications by authors named "Xiaotian Chen"

Article Synopsis
  • * High BPAF exposure significantly lowered survival rates, changed sex ratios, and improved body growth but impaired swimming ability while causing major health issues like disrupted ovarian development and liver inflammation.
  • * The study found that BPAF exposure affected key gene expressions related to the nervous and reproductive systems, alongside altering gut microbiota, indicating severe neurotoxic and reproductive risks from this environmental pollutant.
View Article and Find Full Text PDF
Article Synopsis
  • Maternal liver dysfunction during early pregnancy may increase the risk of spontaneous pregnancy loss (SPL), with a 49% higher risk reported in affected women.
  • Data from over 10,000 pregnant women in Shanghai identified 918 cases of SPL, showing a significant link between elevated liver function biomarkers (LFBs) and SPL occurrences.
  • The study highlights that higher levels of specific enzymes, γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP), are connected to an increased risk of SPL, suggesting the need for monitoring liver health in pregnant women.
View Article and Find Full Text PDF

Conductive hydrogels hold great promise for flexible electronics. However, the simultaneous achievement of satisfactory mechanical strength, outstanding environmental tolerance, high sensitivity, and multiple sensing applications in a single conductive hydrogel remains a significant challenge. Herein, ionic polymer-based hydrogels with a double conductive network consisting of [2-(methacryloyloxy)ethyl] trimethyl ammonium chloride (DMC), 2-hydroxyethyl acrylate (HEA) and silver nanoparticle decorated cellulose nanocrystal (CNC@Ag) are prepared by a facile one-pot method.

View Article and Find Full Text PDF
Article Synopsis
  • This study explores how Chinese cordyceps aqueous extracts (WCCs) protect mpc5 cells from injury caused by the chemotherapy drug adriamycin (ADM) by analyzing gene expression changes through transcriptomic analysis.
  • The researchers used various methods, including HPLC and RNA sequencing, to identify that WCCs help restore normal gene levels primarily in pathways related to one-carbon metabolism and cell signaling, which enhance cellular processes like DNA repair and immune function.
  • The findings suggest that WCCs offer new insights into potential treatments for kidney-related diseases, especially regarding how they interact with genes associated with human diseases.
View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted on 1000 preconception Chinese women to identify genetic factors (SNPs) affecting folate levels and related biomarkers like vitamin B-12 and homocysteine.
  • Key findings included that the MTHFR rs1801133 SNP significantly influenced RBC folate and homocysteine, while other SNPs were linked to serum folate and vitamin B-12 levels.
  • This research is the first of its kind in this demographic, highlighting the genetic factors affecting nutrient levels important for pregnancy preparation.
View Article and Find Full Text PDF
Article Synopsis
  • * Traditional surveillance relies on systems like the FDA’s FAERS, but social media data, particularly from platforms like X (formerly Twitter), provides valuable real-world insights despite being challenging to analyze due to its text-based nature.
  • * The study developed and evaluated several large language models (LLMs) for classifying ADEs from social media, with RoBERTa-large performing the best, highlighting LLMs' potential to enhance ADE detection and improve drug safety monitoring.
View Article and Find Full Text PDF

Objective: To investigate the application experiences and effectiveness of the infra-acetabular screw (IAS) placement technique in acetabular fracture surgery.

Methods: A clinical data of 34 patients with complex acetabular fractures with anterior and posterior columns separation, who were admitted between January 2019 and October 2023 and treated with IAS fixation, was retrospectively analyzed. There were 23 males and 11 females with an average age of 55.

View Article and Find Full Text PDF

Objective: The effects of Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) in primiparas remain unclear. This study examines the associations of pre-pregnancy BMI and GWG with cesarean delivery after induction (CDaI) in primiparous women.

Methods: This prospective cohort study included 3,054 primiparous women.

View Article and Find Full Text PDF

The increasing production of industrial solid waste requires better disposal solutions. Porous hollow microspheres (PHM) are small inorganic materials with high surface area and adsorption capacity, but their potential for use in anaerobic digestion (AD) has not been explored. With PHM as additive, the effects of different industrial solid wastes (waste glass, steel slag, and fly ash) with different loadings (2 %-8 %), respectively, on the AD of corn straw were investigated in this study.

View Article and Find Full Text PDF

Background And Objectives: The current study aimed to explore the effect of nutritional prehabilitation on the clinical prognosis of elderly patients undergoing abdominal cancer surgery.

Methods And Study Design: A retrospective study was conducted, where participants were divided into two groups based on whether they received oral nutritional supplementation at the first outpatient visit. The nutritional prehabilitation group (n=41) adopted a nutritional prehabilitation mode (a standard energy intake of 25-30 kcal/kg· d was recommended).

View Article and Find Full Text PDF

Purpose: This study aims to evaluate a combined effect of dietary folic acid intake, multiple genetic polymorphisms in folate metabolism, and other environmental factors on red blood cell (RBC) folate concentration in pregnancy-preparing population.

Methods: 519 pregnancy-preparing subjects (260 couples) were investigated. Dietary intake was measured by 3-day dietary recalls.

View Article and Find Full Text PDF

Objective: Evaluation of the clinical efficacy of f trochanteric flip osteotomy combined with Kocher-Langenbeck approach for high acetabular posterior wall fracture.

Methods: Between January 2020 and December 2022, 20 patients with high acetabular posterior wall fractures were retrospectively analyzed, including 12 males and 8 females, aged 18 to 75 years old. They were divided into two groups according to the different surgical methods.

View Article and Find Full Text PDF

Objective: To examine the dose-response relationship between specific types of exercise for alleviating Timed up and Go (TUG) in Parkinson's disease PD.

Design: Systematic review and Bayesian network meta-analysis.

Data Sources: PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 5th, 2024.

View Article and Find Full Text PDF

Background: Sarcopenic obesity (SO) in patients with gastrointestinal cancer is associated with a poor prognosis. We aimed to investigate the prognostic impact of SO in patients with gastrointestinal cancer, as well as the diagnostic cut-off value of SO in patients with gastrointestinal cancer among Chinese population.

Methods: We conducted a consecutive cohort study.

View Article and Find Full Text PDF

Gradient anaerobic digestion reactor (GADR) can improve substrate utilization efficiency by solving the problem of the "short circuit" of materials. However, the substrate's composition significantly affects the reactor's performance. This study investigated the impact of food waste (FW) levels on corn straw's dry anaerobic digestion (AD) in a novel GADR.

View Article and Find Full Text PDF

Nocturnal scratching substantially impairs the quality of life in individuals with skin conditions such as atopic dermatitis (AD). Current clinical measurements of scratch rely on patient-reported outcomes (PROs) on itch over the last 24 h. Such measurements lack objectivity and sensitivity.

View Article and Find Full Text PDF

Variation in availability, format, and standardization of patient attributes across health care organizations impacts patient-matching performance. We report on the changing nature of patient-matching features available from 2010-2020 across diverse care settings. We asked 38 health care provider organizations about their current patient attribute data-collection practices.

View Article and Find Full Text PDF

Background: As a severe morbidity during pregnancy, the etiology of spontaneous pregnancy loss (SPL) remains largely unknown. Serum glycated hemoglobin (HbA) level is an established predictor of SPL risk among women with diabetes, but little is known about whether such an association exists among pregnant women without diabetes when glycemic levels are within the normal range.

Objective: This study aimed to quantify the association between maternal HbA levels in early pregnancy and subsequent SPL risk in a cohort of pregnant women without diabetes.

View Article and Find Full Text PDF

Objective: The INFIX technique is becoming one of the most commonly performed surgical procedures for anterior pelvic ring instability injuries. The purpose of this article is to compare the clinical outcomes of modified anterior subcutaneous internal fixation (M-INFIX) with conventional anterior subcutaneous internal fixation (C-INFIX) for anterior pelvic ring instability injuries.

Patients And Methods: A retrospective analysis of 36 cases of unstable pelvic injuries treated operatively at our institution, 20 of which were treated with C-INFIX and 16 with M-INFIX.

View Article and Find Full Text PDF

In China, the problem of low biogas yield of traditional biogas projects has become increasingly prominent. This study investigated the effects of different hydraulic retention times (HRTs) on the biogas production efficiency and microbial community under pilot conditions. The results show that the "Gradient anaerobic digestion reactor" can stably carry out semi-continuous dry anaerobic digestion and improve biogas yield.

View Article and Find Full Text PDF

Background And Objectives: Lack of professional and accurate diagnosis of malnutrition led to a reduction in Diagnosis Related Group (DRG) payment and a decrease in Case-Mix Index (CMI). The aim of this study was to explore the effects of adding a proper nutritional diagnosis and modifying complication groups on DRG payment and CMI.

Methods And Study Design: Retrospective analysis was performed on patients ad-mitted to the hospital from January to June 2022 who had received a nutritional assessment.

View Article and Find Full Text PDF

Objective: The aim of this study was to investigate the effectiveness of an intermittent low-carbohydrate diet (ILCD) versus calorie restriction (ICR) in young populations and potential mechanisms.

Methods: Thirty-four participants aged 9 to 30 years with cardiometabolic risk were randomized to receive a self-administered 2-week ILCD (carbohydrate intake ≤ 50 g/d on seven nonconsecutive days) or ICR (500-600 kcal/d for two consecutive days per week). Differences in changes in obesity measures, glycemic and lipid profiles, gut microbiota composition, and three serum biomarkers were compared.

View Article and Find Full Text PDF

Objectives: Clarify the prognostic value of the Johns Hopkins Hospital Nutrition Support (JHHNS) score on clinical outcomes in older patients undergoing cardiovascular surgery with cardiopulmonary bypass (CPB).

Design: A retrospective observational study.

Setting: A teaching and university hospital and tertiary referral center.

View Article and Find Full Text PDF

In recent decades, there has been growing interest in leveraging external data information for clinical development as it improves the efficiency of the design and inference of clinical trials when utilized properly and more importantly, alleviates potential ethical and recruitment challenges. When it is of interest to augment the concurrent study's control arm using external control data, the potential outcome heterogeneity across data sources, also known as prior-data conflict, should be accounted for. In addition, in the outcome modeling, inclusion of prognostic covariates that may have impact on the outcome can avoid efficiency loss or potential bias.

View Article and Find Full Text PDF

Background: Clinical assessment and grading of left ventricular diastolic function (LVDF) requires quantification of multiple echocardiographic parameters interpreted according to established guidelines, which depends on experienced clinicians and is time consuming. The aim of this study was to develop an artificial intelligence (AI)-assisted system to facilitate the clinical assessment of LVDF.

Methods: In total, 1,304 studies (33,404 images) were used to develop a view classification model to select six specific views required for LVDF assessment.

View Article and Find Full Text PDF