Phosphorylated protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) expression in breast cancer is correlated with malignant proliferation and histological grading.

This study aims to detect the expression of phosphorylated PERK in breast cancer using immunohistochemistry and explore its significance. We examined 134 cases of formalin-fixed and paraffin-embedded breast cancer tissues. It was found that the expression of phosphorylated PERK in ductal carcinoma was higher than that in lobular carcinoma, and the difference between them was statistically significant, suggesting that phosphorylated PERK played different roles in the occurrence and development of different types of breast cancer.

Discovery of novel NLRP3 inhibitors based on machine learning and physical methods.

The NLRP3 inflammasome plays a crucial role in inflammatory responses, particularly in alcohol-related liver disease (ALD). Given that NLRP3 has emerged as a potential therapeutic target for ALD, the development of effective inhibitors is of great importance. In this study, we trained 11 regression models, and the results showed that LightGBM, Random Forest, and XGBoost performed the best, achieving R² values of 0.

Precast Assembled Road Paving Technology: Progress and Prospects.

This article presents a systematic review of the most cutting-edge research on precast pavement technology for the first time. Firstly, precast pavement is divided into two categories, precast cement concrete pavement and precast carpeted flexible pavement, according to the application of precast technology in pavement engineering. Subsequently, the structural characteristics, advantages, and disadvantages of various precast pavement systems are compared and analyzed; technical problems in precast pavement systems are explained; and future development directions are identified.

Effect of Industrial Solid Waste as Fillers on the Rheology and Surface Free Energy of Asphalt Mastic.

The continuous growth of industrial solid waste production has generated many environmental problems. We evaluated the potential of industrial solid waste as a substitute filler in asphalt mastic, with the aim of increasing the use of sustainable road construction materials. In this study, X-ray fluorescence spectroscopy (XRF) and scanning electron microscopy (SEM) were used to characterize the oxide composition and micromorphology of limestone (LS), red mud (RM), steel slag (SS), and ground granulated blast-furnace slag (GGBFS).

Effects of Wnt/β-catenin signaling on bisphenol A exposure in male mouse reproductive cells.

Bisphenol A (BPA) is a chemical used in numerous consumer products that is able to interfere with the mammalian endocrine system. The aim of the present study was to investigate the effects of BPA on male mouse reproductive cells following prenatal to postnatal exposure. In addition, the influence of BPA was detected on the expression levels of β‑catenin and dickkopf WNT signaling pathway inhibitor 1 (DKK‑1) during the differentiation of spermatogenic cells in the mouse testes.