Publications by authors named "Xiaoshun Qian"
Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.
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- The study explored gut microbiota differences in patients with severe obstructive sleep apnea (OSA) and how these changes occur after three months of CPAP treatment.
- Using various analysis methods, the research found specific bacterial populations significantly altered in OSA patients compared to healthy controls and showed correlations between certain gut bacteria and blood pressure levels.
- The findings indicate that gut microbiota and metabolic pathways are notably different in OSA patients, and that CPAP therapy can meaningfully impact both gut bacteria composition and overall health.
Background: The concomitant rise in the prevalence of obstructive sleep apnea (OSA) and frailty among the elderly population has been linked to an increase in mortality rates. Despite continuous positive airway pressure (CPAP) being the gold standard treatment for OSA, its impact on incident frailty remains inadequately explored.
Methods: In this cohort study, we analyzed data from 1290 patients diagnosed with OSA, aged 60 years and older.
To investigate the association between obstructive sleep apnea (OSA) severity and baseline serum cystatin C (Cys-C) concentration and to explore the association between baseline serum Cys-C and long-term cardiovascular outcomes and mortality in older patients with OSA. Between January 2015 and October 2017, a total of 1107 consecutive eligible older patients (≥60 years) with OSA were included in this multicenter, prospective cohort study, and baseline demographics, clinical characteristics, sleep parameters, and follow-up outcomes were collected. Participants were divided into different groups based on baseline serum Cys-C levels.
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- This study examined how common atrial fibrillation (AF) is in older patients with obstructive sleep apnea (OSA) in China, involving 1,285 participants over three years.
- It found that 9.5% of patients had AF, which increased with age but not significantly with the severity of OSA.
- The analysis identified that factors such as age, a history of alcohol consumption, chronic heart disease, diabetes, and reduced diastolic function are all linked to higher rates of AF in these patients.
Few prospective cohort studies have assessed the relationship between Cystatin C (Cys-C) and risk of stroke in elderly patients with obstructive sleep apnea (OSA). The study sought to examine the association between baseline serum Cys-C and long-term risk of stroke among elderly OSA patients. A total of 932 patients with OSA, no history of stroke, ≥60 years of age, and complete serum Cys-C records were included in this study.
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- The study investigates the impact of obstructive sleep apnea (OSA) on cardiovascular disease (CVD) risk and mortality in elderly patients, particularly comparing those with type 2 diabetes to those without it.
- A total of 1,113 elderly patients were monitored, with 266 (23.9%) diagnosed with OSA who also had type 2 diabetes, leading to notable findings over a 42-month follow-up period.
- Results indicated that type 2 diabetes significantly increased the risk of major adverse cardiovascular events, with specific risks for unstable angina and other health complications, although there were no significant differences in overall mortality rates.
[Cardiac functional alterations and its risk factors in elderly patients with obstructive sleep apnea syndrome free of cardiovascular disease].
Nan Fang Yi Ke Da Xue Xue Bao
November 2020
Objective: To evaluate the changes of cardiac structure and function and their risk factors in elderly patients with obstructive sleep apnea syndrome (OSA) without cardiovascular complications.
Methods: Eighty-two elderly OSA patients without cardiovascular disease admitted between January, 2015 and October, 2016 were enrolled in this study. According to their apnea-hypopnea index (AHI, calculated as the average number of episodes of apnoea and hypopnoea per hour of sleep), the patients were divided into mild OSA group (AHI < 15) and moderate to severe OSA group (AHI ≥ 15).
[Correlation between severity of obstructive sleep apnea syndrome and red cell distribution width in elderly patients].
Nan Fang Yi Ke Da Xue Xue Bao
May 2020
Objective: To investigate the correlation between the severity of obstructive sleep apnea syndrome (OSAS) and red cell distribution width (RDW) in elderly patients.
Methods: A cross-sectional study was conducted among 311 elderly patients diagnosed with OSAS in the snoring clinic between January, 2015 and October, 2016 and 120 healthy controls without OSAS from physical examination populations in the General Hospital of PLA. The subjects were divided into control group with apnea-hypopnea index (AHI) <5 (=120), mild OSAS group (AHI of 5.
Objective: This study aims to gain further insight into the association between migraine and restless legs syndrome (RLS).
Methods: A literature search of PubMed, Embase, and Web of Science was performed for studies investigating the association between any migraine and RLS; a meta-analysis of eligible studies was conducted to determine a pooled effect estimate for the association.
Results: Fifteen studies were included in this meta-analysis.
Background: Multiple organ dysfunction syndrome in the elderly (MODSE) is a problem with high mortality in the critical care of elderly patients. The pathogenesis of MODSE remains elusive. This study aimed to establish rat models of MODSE and to investigate the pathogenetic mechanism responsible for the development of MODSE in the rat models.
View Article and Find Full Text PDFHypertension induced by obstructive sleep apnea (OSA) may be multifactorial in origin, and systemic inflammation is one of the major factors. However, OSA patients do not always have the identical probability with hypertension even in patients with the same history and degree of OSA. The aim of this study was to compare the levels of inflammation and insulin resistance in two groups of patients who had the same degree as well as the same long history of OSA, but with/without hypertension.
View Article and Find Full Text PDFMultiple organ dysfunction syndrome (MODS) in the elderly is the most common cause of mortality in critically ill elderly patients, and it is different from MODS in the adult in clinic. Rare studies have been done on its pathogenesis and the comparison between adult and elderly MODS animal models. This work aimed at exploring the mechanisms mediating elderly MODS and compared this with adult MODS.
View Article and Find Full Text PDF[Apoptosis of pulmonary alveolar macrophages in aged and adult rats: a comparative study].
Zhonghua Yi Xue Za Zhi
January 2005
Objective: To investigate the role of alveolar macrophages (AM) in the initiation of multiple organ failure in the elderly (MOFE).
Methods: Three-month-old (adult) and 24-month-old (aged) males SD rats were used as experimental animals. Zymosan 0.