Undescribed sesquiterpene coumarins from the aerial parts of Ferula sinkiangensis and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW 264.7 macrophages.

Eight undescribed sesquiterpene coumarins (1-8) and twenty known ones (9-28), were isolated from the aerial parts of Ferula sinkiangensis K. M. Shen.

Novel Triterpenoid Alkaloids With Their Potential Cytotoxic Activity From the Roots of .

Four novel triterpenoid alkaloids, siragrosvenins A-D (), and two new cucurbitane-type triterpenoids, siragrosvenins E-F (, ), together with eight known analogs (), were isolated from the roots of . Compounds possessed a rare cucurbitane-type triterpenoid scaffold, featuring an extra pyrazine unit the Strecker reaction in the cucurbitane framework. Compound displayed a 6/6/6/5/6/5-fused polycyclic ring system, with an uncommon fused furan and pyran ring in the side chain.

The Inhibition of Gastric Cancer Cells' Progression by 23,24-Dihydrocucurbitacin E through Disruption of the Ras/Raf/ERK/MMP9 Signaling Pathway.

Gastric cancer is considered to be one of the most common causes of cancer death worldwide due to its high recurrence and metastasis rates. The molecule 23,24-Dihydrocucurbitacin E (DHCE) is a cucurbitacin-derived tetracyclic triterpenoid compound that has anti-tumor activity, but the exact mechanism remains to be elucidated. This research aimed to explore the effects of DHCE on human gastric cancer cells and the possible mechanisms.

New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis.

Four undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2, 4)-sinkiangenoxide C, and (2, 4)-sinkiangenoxide C (1:  - 4: ), and one known compound, 1-(methylthio)propyl ()-1-propenyl disulfide (5: ), were isolated from the resin of . Their structures were determined based on spectroscopic methods, including IR, UV, HRESIMS, NMR, and CD analysis. Compounds 2:  - 4: showed moderate cytotoxic activities against four human cancer cell lines with IC values ranging from 15.