Investigating the diagnostic and prognostic significance of genes related to fatty acid metabolism in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide, with death rates increasing by approximately 2-3% per year. The high mortality and poor prognosis of HCC are primarily due to inaccurate early diagnosis and lack of monitoring when liver transplantation is not feasible. Fatty acid (FA) metabolism is a critical metabolic pathway that provides energy and signaling factors in cancer, particularly in HCC, and promotes malignancy.

tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators.

As the most ancient RNA, transfer RNAs (tRNAs) play a more complex role than their constitutive function as amino acid transporters in the protein synthesis process. The transcription and maturation of tRNA in cells are subject to stringent regulation, resulting in the formation of tissue- and cell-specific tRNA pools with variations in tRNA overall abundance, composition, modification, and charging levels. The heterogeneity of tRNA pools contributes to facilitating the formation of histocyte-specific protein expression patterns and is involved in diverse biological processes.

A Mini Review on Borate Photocatalysts for Water Decomposition: Synthesis, Structure, and Further Challenges.

The development of novel photocatalysts, both visible and UV-responsive, for water decomposition reactions is of great importance. Here we focused on the application of the borates as photocatalysts in water decomposition reactions, including water splitting reaction, hydrogen evolution half-reaction, and oxygen evolution half-reaction. In addition, the rates of photocatalytic hydrogen evolution and oxygen evolution by these borate photocatalysts in different water decomposition reactions were summarized.

Au/TiC/g-CN Ternary Composites Boost H Evolution Efficiently with Remarkable Long-Term Stability by Synergistic Strategies.

The use of novel two-dimensional MXene materials and conventional g-CN photocatalysts to fabricate the composites for hydrogen evolution reaction (HER) has attracted much attention, for which there is plenty of room for the enhancement of hydrogen evolution rates particularly under visible light and photostability. Herein, g-CN was modified by copolymerization of malonamide and melamine and used to fabricate the ternary composites of Au particles and TiC MXene, and based on the synergistic effect, the composites enhanced the hydrogen evolution rates by 2.1, 99.

FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.

Fibrillarin (FBL) is a highly conserved nucleolar methyltransferase responsible for methylation of ribosomal RNA and proteins. Here, we reveal a role for FBL in DNA damage response and its impact on cancer proliferation and sensitivity to DNA-damaging agents. FBL is highly expressed in various cancers and correlates with poor survival outcomes in cancer patients.

The metagenomics of soil bacteria and fungi and the release of mechanical dormancy in hard seeds.

Persistence in the soil is a function of seed physiology, particularly non-germination and inherent lifespan. However, for seeds with mechanical dormancy, non-germination is also a function of the composition and activity of the soil microbiota. We attempted to screen out microorganisms in the soil that can specifically and rapidly decompose the hard fruit pericarps of Maxim.

Enzymatic preparation of chondroitin sulfate oligosaccharides and its alleviating effect on ovariectomy-induced osteoporosis in rats.

Postmenopausal osteoporosis is the most common type of osteoporosis. Chondroitin sulfate (CS) has been successfully employed as food supplement against osteoarthritis, while the therapeutic potential on postmenopausal osteoporosis is little explored. In this study, CS oligosaccharides (CSOs) were enzymatically prepared through the lysis of CS by a chondroitinase from Microbacterium sp.

Size controllable single-crystalline Ni-rich cathodes for high-energy lithium-ion batteries.

A single-crystalline Ni-rich (SCNR) cathode with a large particle size can achieve higher energy density, and is safer, than polycrystalline counterparts. However, synthesizing large SCNR cathodes (>5 μm) without compromising electrochemical performance is very challenging due to the incompatibility between Ni-rich cathodes and high temperature calcination. Herein, we introduce Vegard's Slope as a guide for rationally selecting sintering aids, and we successfully synthesize size-controlled SCNR cathodes, the largest of which can be up to 10 μm.

Identification of immune-related signature for the prognosis and benefit of immunotherapy in triple-negative breast cancer.

There is a lack of biomarkers for predicting the efficacy of immunotherapy in triple-negative breast cancer (TNBC). Hence, we constructed an immune risk score (IRS) model to predict the prognosis of patients with TNBC and evaluate those who are sensitive to immunotherapy. The ribonucleic acid (RNA) sequencing data, mutation data, and clinical information of TNBC patients were obtained from The Cancer Genome Atlas database.

Research on Learning Evaluation of College Students Based on AHP and Fuzzy Comprehensive Evaluation.

The aim of this paper is to propose a scientific and practical evaluation method for college students' learning evaluation. The students' learning experience and harvest are the ultimate embodiment of colleges teaching quality. Considering the multilevel and fuzzy characteristics of learning evaluation, a novel college evaluation method is put forward based on the analytic hierarchy process and fuzzy comprehensive evaluation.

Review on the release mechanism and debittering technology of bitter peptides from protein hydrolysates.

Recent scientific evidence indicates that protein hydrolysates contain bioactive peptides that have potential benefits for human health. However, the bitter-tasting hydrophobic peptides in protein hydrolysates negatively affect the sensory quality of resulting products and limit their utilization in food and pharmaceutical industries. The approaches to reduce, mask, and remove bitter taste from protein hydrolysates have been extensively reported.

Characteristics of the enzyme-induced release of bitter peptides from wheat gluten hydrolysates.

Bitter peptides in the enzymatic hydrolysates were prepared and purified from wheat gluten using aqueous ethanol solutions and macroporous resin, which has opened a new road for the extraction and separation of bitter peptides. This report contains the release regularity of bitter peptides and the factors affecting the change of bitter intensity during enzymatic hydrolysis, providing a scientific basis for the research on debitterizing method. In this study, the effects of different degrees of hydrolysis (DH) and enzyme active sites on the bitter peptide content and bitter taste thresholds were discussed.

DSA Image Analysis of Clinical Features and Nursing Care of Cerebral Aneurysm Patients Based on the Deep Learning Algorithm.

Objective: A deep learning algorithm was developed for automatic detection and localization of intracranial aneurysms in DSA, and its clinical characteristics were analyzed, and targeted nursing measures were formulated.

Methods: Using a retrospective multicenter study method based on radiology reports, DSA images of aneurysms were randomly divided into 75 cases in the training set, 20 cases in the internal test set, and 35 cases in the external test set. Using a computer-aided detection method based on the three-dimensional U-Net (3D U-Net), after preprocessing DSA images, automatic segmentation of intracranial blood vessels is performed to obtain regions of interest, and based on the segmentation results, physicians' annotations are introduced.

Metagenomic analysis reveals the different characteristics of microbial communities inside and outside the karst tiankeng.

Background: Karst tiankengs serve as a reservoir of biodiversity in the degraded karst landscape areas. However, the microbial diversity of karst tiankengs is poorly understood. Here, we investigated the composition and function of the microbial community in a karst tiankeng.

Fine Identification and Classification of a Novel Beneficial Fungal Species from Masson Pine Rhizosphere Soil.

Rhizosphere fungi have the beneficial functions of promoting plant growth and protecting plants from pests and pathogens. In our preliminary study, rhizosphere fungus JP-NJ4 was obtained from the soil rhizosphere of and selected for further analyses to confirm its functions of phosphate solubilization and plant growth promotion. In order to comprehensively investigate the function of this strain, it is necessary to ascertain its taxonomic position.

Screening LiMnO Surface Modification Schemes under Theoretical Guidance.

Mn dissolution is one of the most important factors for the failure of LiMnO batteries. Doping has been widely adopted in the modification of LiMnO cathodes; however, there is still a lack of theoretical guidance on screening the dopants. Here, through first-principles calculations, we systematically investigated the effects of all 3, 4d transition metals as well as Mg, Ca, Sr, Al, Ga, and In on the surface oxygen stability of LiMnO cathodes, which has been proved to be correlated with the stability of the surface Mn atoms.

Identification of Two Fungal Pathogens Responsible for × Black Spot and Screening of sp. for Disease Control.

× black spot is a newly discovered disease that causes yellowing and early shedding of leaves, affecting the growth of trees, and significantly reducing their ornamental value as a garden species. The pathogen responsible for this disease, and how it can be prevented and controlled, are not clear. In this study, the occurrence of this disease was first investigated according to Koch's postulates, and the primary pathogens causing Liriodendron black spot were determined to be and .

Photo-Fenton Process over an Fe-Free 3%-CuO/SrCeWO Photocatalyst under Simulated Sunlight.

Photo-Fenton is a promising photocatalytic technology that utilizes sunlight. Herein, an Fe-free 3%-CuO/SrCeWO photocatalyst was synthesized to apply simulated wastewater degradation via a photo-Fenton process under simulated sunlight. The photodegradation efficiency of RhB solution over the 3%-CuO/SrCeWO photocatalyst is 93.

Reaction Mechanisms of Ta-Substituted Cubic LiLaZrO with Solvents During Storage.

The reactivity of garnet solid electrolytes toward humid air hinders their practical application despite their attractive, superior properties such as high Li conductivity and wide electrochemical window. Sealing garnets with organic solvents can not only prevent them from reacting with humid air but also render them compatible with other processing technologies. Therefore, the chemical and structural stability of garnets in organic solvents must be studied.

First-Principles Simulations for the Surface Evolution and Mn Dissolution in the Fully Delithiated Spinel LiMnO.

The interfacial stability between the cathode and electrolyte is an essential issue in the development of high-energy-density and long-life lithium-ion batteries. The deterioration of capacity dominated by Mn dissolution makes LiMnO a representative case for studying the evolution of interfaces. Here, we use the ab initio molecular dynamics (AIMD) method to simulate the interface reaction between the ethylene carbonate (EC) molecules and the (110) surface of completely delithiated LiMnO where most severe Mn dissolution is observed in the experiment.

Photocatalytic Reduction of Cr(VI) on a 3.0% Au/SrCeWO Photocatalyst.

Herein, a 3.0%-Au/SrCeWO sample was prepared for the photocatalytic reduction of the CrO ion. The photocatalyst was characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and ultraviolet-visible diffuse reflectance spectra.

First report of leaf spot disease caused by Neopestalotiopsis chrysea on Carya illinoinensis in China.

Pecan (Carya illinoinensis) is important and widely planted nut tree species in Anhui province in China. In a pecan orchard in Anhui, China, 54% of the 1-year-old container-grown seedlings in the nursery developed leaf spots in September 2019. Initially, the brown spots appeared on the leaves.

Forest Tree Associated Bacterial Diffusible and Volatile Organic Compounds against Various Phytopathogenic Fungi.

Plant growth-promoting rhizobacteria (PGPR) can potentially be used as an alternative strategy to control plant diseases. In this study, strain ST-TJ4 isolated from the rhizosphere soil of a healthy poplar was found to have a strong antifungal activity against 11 phytopathogenic fungi in agriculture and forestry. Strain ST-TJ4 was identified as sp.

Effects of an Omaha system-based continuing nursing program on nutritional status in patients undergoing peritoneal dialysis: a randomized controlled trial.

Purpose: This study was aimed to develop and conduct an Omaha system-based continuing nursing program for chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) and to explore its effect on patients' nutritional status.

Methods: A randomized controlled trial was performed in a teaching hospital in China between June 2017 and July 2018. A total of 203 eligible patients were included and then randomly assigned to the study group (n = 101) or the control group (n = 102).