Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease.

Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms and treatments remain elusive. Here we report the therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model of Alzheimer's disease. Our findings reveal that light treatment prevents memory decline in 4-month-old 5xFAD mice and motivation loss in 14-month-old 5xFAD mice, accompanied by restoration of glial water channel aquaporin-4 polarity, improved brain drainage efficiency, and a reduction in hippocampal lipid accumulation.

Lignin-based hyper-cross-linked resin as an adsorbent for aniline from aqueous solution.

Lignin serves as an ideal substrate for the synthesis of chemically functionalized hyper-cross-linked resins due to the structural composition of its aromatic rings, aliphatic side chains, and multiple active functional groups. These resins have shown to be highly effective in the adsorption of aromatic compounds. In this study, hyper-cross-linked polymer (HCPs-3), synthesized using 1,3,5-triphenyl and lignin, demonstrated a significant adsorption capacity for aniline, with a maximum adsorption capacity (q) of 189.

A Design Methodology for Fault-Tolerant Neuromorphic Computing Using Bayesian Neural Network.

Memristor crossbar arrays are a promising platform for neuromorphic computing. In practical scenarios, the synapse weights represented by the memristors for the underlying system are subject to process variations, in which the programmed weight when read out for inference is no longer deterministic but a stochastic distribution. It is therefore highly desired to learn the weight distribution accounting for process variations, to ensure the same inference performance in memristor crossbar arrays as the design value.

Motivation-based segmentation of game meat consumers: A look at the beliefs of food consumers during the COVID-19 crisis in China.

Objectives: This research aims to explore the factors motivate consumers to eat game meat during a multi-state disease outbreak.

Methods: It proposes a segmentation of consumers based on their attitudes toward and reveals the consumers' food beliefs that motivate their actions. Three segments of game meat consumers were identified: identity seekers, health seekers, and taste seekers.

Generational Differences in Perceptions of Food Health/Risk and Attitudes toward Organic Food and Game Meat: The Case of the COVID-19 Crisis in China.

In December 2019, a novel laboratory-confirmed coronavirus (2019-nCoV) infection, which has caused clusters of severe illnesses, was first reported in Wuhan, the capital of Hubei province, China. This foodborne illness, which reportedly most likely originated in a seafood market where wild animals are sold illegally, has transmitted among humans through close contact, across the world. The aim of this study is to explore health/risk perceptions of and attitudes toward healthy/risky food in the immediate context of food crisis.