Publications by authors named "Xiaoru Chai"
Unlabelled: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus that undergoes rapid mutation. Based on viral whole genome sequencing analysis in Hebei Province, China, we identified several essential single nucleotide variants (SNVs) on primer-probe regions accumulating within some Omicron variants' genomes. In this study, we focused on three SNVs, C28290T, T28297C, and C28311T emerging on 2019-nCoV-N1 (CDC-N1) primer-probe regions, recommended by CDC in 2020, and two SNVs, C26270T, A26275G emerging on E (Charité-E) primer-probe regions recommended by Charité, Germany.
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- The study focused on the first long-term monitoring of SARS-CoV-2 in wastewater in Shijiazhuang, China, between November 2021 and October 2023.
- A new RT-ddPCR method was developed for more accurate detection of SARS-CoV-2 by targeting specific gene markers alongside a control virus, PMMoV.
- Results indicated a strong correlation between SARS-CoV-2 concentrations in wastewater and COVID-19 case numbers, demonstrating the effectiveness of wastewater monitoring for public health tracking.