Analysis of the clinical features and risk factors of kidney injury in patients with chronic heart failure-a retrospective cohort study.

Background: Heart failure (HF) often leads to kidney injury and increased morbidity and mortality. Factors contributing to kidney injury in HF patients had not been elucidated completely. This study sought to comprehensively evaluate the risk factors and clinical features of kidney injury in patients with chronic heart failure (CHF) and to provide more evidence for the management of these patients.

Responses of Rice and Related Cadmium Transporter Genes to the Passivating Microbial Agent MBLHAP.

Alkali-producing microorganisms and hydroxyapatite (HAP), a chemical passivation agent, have a certain remediation effect on cadmium (Cd) -contaminated soil. They can decrease the available Cd content in the soil to a certain extent and reduce the overall Cd content of rice planted in the soil. The Cd-contaminated soil was treated with the passivating bacterial agent that had been developed.

The role of autophagy-related proteins in the pathogenesis of neuromyelitis optica spectrum disorders.

This study aimed to investigate the expression of autophagy-related proteins in a mouse model of neuromyelitis optica (NMO). Mice were assigned to one of four groups: an animal experimental model group (NMO-EAE group, given with exogenous IL-17A), Interleukin-17 monoclonal antibody intervention group (NMO-EAE_0IL17inb), No exogenous interleukin-17 enhanced immune intervention group (NMO-EAE_0IL17), and a control group. Behavioral scores were assessed in each group, and the protein expressions of sequestosome 1 (P62), Beclin-1, the mammalian target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K-I), and LC3II/LC3I were detected using Western blotting.

Engineering of Defect-Rich CuWS Nano-homojunctions Anchored on Covalent Organic Frameworks for Enhanced Gaseous Elemental Mercury Removal.

Fabricating two-dimensional transition-metal dichalcogenide (TMD)-based unique composites is an effective way to boost the overall physical and chemical properties, which will be helpful for the efficient and fast capture of elemental mercury (Hg) over a wide temperature range. Herein, we constructed a defect-rich CuWS nano-homojunction decorated on covalent organic frameworks (COFs) with abundant S vacancies. Highly well-dispersed and uniform CuWS nanoparticles were immobilized on COFs strongly via an ion pre-anchored strategy, consequently exhibiting enhanced Hg removal performance.

Tire pyrolysis wastewater treatment by a combined process of coagulation detoxification and biodegradation.

Recycling waste tires through pyrolysis technology generates refractory wastewater, which is harmful to the environment if not disposed properly. In this study, a combined process of coagulation detoxification and biodegradation was used to treat tire pyrolysis wastewater. Organics removal characteristics at the molecular level were investigated using electrospray ionization (ESI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).

A Retrospective Study of the Clinical Characteristics of Japanese Encephalitis in Adults.

Objective: This study aimed to explore the diagnostic points and treatment modes of the clinical characteristics of Japanese encephalitis (JE) in the middle-aged and elderly population.

Methods: Six patients aged 47-72 who were diagnosed with JE at the Beijing Chaoyang Hospital Affiliated with the Capital Medical University between August 2018 and September 2019 were enrolled in the study. Their clinical manifestations, biochemical indicators, imaging data, diagnostic methods, and the evolution and outcomes of the treatments they underwent were retrospectively analyzed.

HDAC3 of dorsal hippocampus induces postoperative cognitive dysfunction in aged mice.

Postoperative cognitive dysfunction (POCD) affects a substantial number of aged individuals. Although advanced age has been regarded as the only independent risk factor for cognitive decline following anesthesia and surgery, the exact cellular and molecular mechanisms remain poorly understood. Histone deacetylase 3 (HDAC3), an epigenetic regulator of memory plays an important role in age-dependent disease.

Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.

Helicobacter pylori (H. pylori), a microbial carcinogen of Gram-negative bacteria, has been recognized to be the highest risk factor for the growth of human gastric cancer (GC). Therefore, the inhibition of the growth rate of H.

LncRNA H19 induced by helicobacter pylori infection promotes gastric cancer cell growth via enhancing NF-κB-induced inflammation.

Background: The aim of this study was to investigate the role of long non-coding RNA (lncRNA) H19 in gastric cancer (GC) with Helicobacter pylori ().

Methods: H19 expression in peripheral blood from +/- GC patients and healthy donors (control) as well as in GC tissues and cells were detected by qRT-PCR. Cell proliferation was evaluated by CCK-8 assay.

The Association between Infertility and Helicobacter pylori Infection: a Meta-Analysis of Case-control Studies.

Background: Helicobacter pylori (H. pylori) is increasingly associated with extra-digestive diseases. Infertility is a common condition, with an incidence of 10 to 15% of couples.

Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis.

The association between circulating microRNA-375 (miR-375) expression and cancers has been studied; however, the results are inconsistent. We searched PubMed, Embase, and Web of Science for studies concerning the diagnostic value of miR-375 for cancer. The bivariate meta-analysis model was employed to summarize sensitivity, specificity, and diagnostic odds ratio (DOR) for miR-375 in the diagnosis of cancer.

Long Noncoding RNA H19/miR-675 Axis Promotes Gastric Cancer via FADD/Caspase 8/Caspase 3 Signaling Pathway.

Background: Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types of cancer and miR-675 is reported to be embedded in H19's first exon. However, their function and specific mechanisms of action have not been fully elucidated. The aim of this study was to identify a novel lncRNA-microRNA-mRNA functional network in gastric cancer.

MicroRNA-150 as a Potential Biomarker in Diagnosis of Cancer: a Meta-Analysis.

Background: Altered expression of microRNAs contributes to human carcinogenesis. Previous studies assessed the association of aberrant circulating microRNA (miR)-150 level with the risk in developing various human cancers, but the data were inconsistent.

Methods: This meta-analysis further assessed the potential diagnostic value of miR-150 in cancer.

The effect of activin A on signal transduction pathways in PC12 cells subjected to oxygen and glucose deprivation.

The processes and mechanisms underlying brain injuries due to ischemia and anoxia have yet to be determined. Additionally, few clinical treatements are currently available. Activins have a protective role in the restoration, differentiation, and survival of injured cells, including Activin A (ActA), which acts as a neuroprotectant.

Emodin prevents hypoxic-ischemic neuronal injury: Involvement of the activin A pathway.

Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subjected to oxygen-glucose deprivation and treated with emodin.