Furmonertinib for EGFR-mutant advanced non-small cell lung cancer: a glittering diamond in the rough of EGFR-TKI.

The third-generation EGFR-TKIs, such as osimertinib, aumolertinib, and furmonertinib, have been recommended as the preferred treatment for EGFR-mutant advanced non-small cell lung cancer (NSCLC). Among them, furmonertinib shows several advantages in terms of clinical efficacy. Firstly, compared to osimertinib and aumolertinib, furmonertinib was the first EGFR-TKI with median progression-free survival (mPFS) of over 20.

Sexual orientation and psychotic-like experiences among Chinese college students: the role of gender.

Objective: The mental health of sexual minorities has received increasing attention, but there are few studies on the risk of psychotic-like experiences (PLEs) among sexual minorities. The purpose of this study is to explore the relationship between different sexual orientations and PLEs among college students and the moderating effect of gender.

Methods: A total of 4,460 college students from seven provinces participated in this cross-sectional survey.

The Prevalence and Severity of School Bullying among Left-Behind Children: A Meta-Analysis.

The involvement of left-behind children (LBC) in school bullying has raised concern in China. However, the susceptibility of LBC to engage in bullying is controversial, and comprehensive, representative studies covering the entire country are lacking. The purpose of this study was to evaluate the prevalence and severity of school bullying among LBC.

Prevalence and predictors of bullying among in-school adolescents in Nigeria.

Objective: As an emerging significant public health issue affecting many students globally, school bullying is a threat that should not be disregarded. While several published studies have focused on bullying in developed countries, very little is known about the prevalence and predictors of bullying in Nigeria. This study aimed to determine the prevalence and predictors of bullying in secondary schools in Edo State, Nigeria.

The relationship between school bullying victimization and mental health among high school sexual minority students in China: A cross-sectional study.

Background: School bullying has become a matter of global concern for the general public. Sexual minority youth (SMY) may experience minority stress and victimization which are known to adversely affect mental health and happiness. However, a few scholars explored and linked sexual orientation with campus bullying, depression, and anxiety symptoms under the specific cultural background of China.

School bullying among migrant children in China: A cross-sectional study.

Background: Bullying is a serious public health concern affecting the physical and mental health of children. Migrant children are at higher risk of developing health problems. We conducted this study to investigate the prevalence of school bullying and its possible influencing factors of migrant children.

Association between weight status and bullying experiences among children and adolescents in schools: An updated meta-analysis.

Background: The association between weight status and bullying experience is well established, but little is known about the association between overweight or obesity and bullying behaviors among children and adolescents.

Objective: The aim of this study was to provide updated evidence on the association between weight status and exposure to bullying among school children and adolescents.

Methods: All literature published not later than December 12, 2019 was obtained from PubMed, Web of Science, Embase, and PsycINFO databases.

Psychotic-like experiences and associated socio-demographic factors among pregnant women in each trimester in China.

Objective: Psychotic-like experiences (PLEs) are quite common in the general populations without a clinical diagnosis, but pregnant women have been neglected in earlier literature. This study aimed to investigate the prevalence and correlates of PLEs among pregnant women without previous psychiatric history in each trimester.

Method: A total of 950 pregnant women participated in a cross-sectional survey, with social and demographic information collected.

Luteinizing hormone-based modified GnRH antagonist protocol in normal responders undergoing fertilization treatment: A multi-center randomized controlled trial.

Objective: To study the clinical efficacy and cost-effectiveness of a modified gonadotrophin-releasing hormone (GnRH) antagonist protocol based on luteinizing hormone (LH) levels through one complete assisted reproductive technology (ART) cycle in normal responders.

Design: Non-inferiority, multicenter randomized controlled trial.

Setting: University-based hospitals and an academic medical center.

Prevalence and Associated Family Factors of Sibling Bullying Among Chinese Children and Adolescents.

Sibling bullying is the most common form of aggression within family worldwide, while the prevalence and correlations of sibling bullying is little known in China. The current research focused on the association between family factors and sibling bullying among Chinese adolescents, and explore sex differences in sibling bullying in the context of Chinese culture. A cross-sectional study was conducted to explore the characteristics of sibling bullying by sampling 6302 children and adolescents who had at least 1 sibling living in the household.

Co-occurrence of sibling and peer bullying victimization and depression and anxiety among Chinese adolescents: The role of sexual orientation.

Background: Bullying victimization is a robust predictor of mental distress among lesbian/gay, bisexual, and questioning (LGBQ) adolescents. However, few research accounted bullying victimization within the context of both sibling and peer relationships.

Objective: To examine the effect of sibling and peer bullying victimization on depression and anxiety between heterosexual adolescents and LGBQ adolescents.

Effects of ambient air pollution, fresh fruit and vegetable intakes as well as maternal psychosocial stress on the outcome of newborn otoacoustic emission hearing screening.

Background: Newborn hearing screening results indicated that more than 40% of the detected infants had no recognized risk factors. To determine whether maternal exposure to ambient air pollutants and experience of stressful life event, as well as lack of fresh fruit and vegetable during pregnancy are associated with the abnormal hearing development among newborns.

Methods: A total of 1193 newborns and their mothers were recruited in this study.

Social and general anhedonia in adolescents: Stability and associations with other symptoms.

Introduction: Recent works have developed two self-report measures of general and social anhedonia for adolescents. Little is known about the relative stability of these constructs and their associations with psychopathological symptoms over time.

Methods: A total of 694 Chinese adolescents aged 14-16 years (74.

Synthesis and preliminary biological evaluation of naproxen-probenecid conjugate for central nervous system (CNS) delivery.

Naproxen, known as the most potent non-steroid anti-inflammatory drugs, is vitally crucial in the treatment of neurodegenerative diseases. However, due to the poor brain penetration ability, it causes serious adverse effects with the therapeutic doses. Predictably, these unfavorable factors have hindered its further application.

Center-Based vs Home-Based Geriatric Rehabilitation on Sarcopenia Components: A Systematic Review and Meta-analysis.

Objective: To investigate the available evidence on the components of sarcopenia in geriatric rehabilitation and to examine whether changes in different settings are associated with sarcopenia.

Data Sources: PubMed, the Cochrane Central Register of Controlled Trials in the Cochrane Library, and Embase were searched from initiation to August 30, 2021.

Study Selection: We included randomized controlled trials of older adults receiving geriatric rehabilitation that included strength exercise training.

A Novel Mutation in the Myosin Binding Protein C Gene in a Prader-Willi Syndrome Pedigree.

Prader-Willi syndrome (PWS) is a neurogenetic disorder caused by deficiency expression of paternally imprinted genes of the chromosomal region 15. In this study, we report a novel mutation in the myosin binding protein C (MYBPC3) gene in a Prader-Willi syndrome pedigree. Next-generation sequencing (NGS) and Sanger sequencing were performed to define and confirm the MYBPC3 gene mutation.

The effect of antibiotic resistance on Helicobacter pylori eradication efficacy: A systematic review and meta-analysis.

Background: The occurrence of antibiotic-resistant strains has been rapidly increasing due to the wide use of antibiotics. To evaluate the current effects of antibiotic resistance on Helicobacter pylori eradication efficacy, we conducted this systematic review and meta-analysis.

Methods: Literature searches were conducted in the following databases: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials.

Association Between Sub-types of Sibling Bullying and Mental Health Distress Among Chinese Children and Adolescents.

Sibling bullying is a common phenomenon in childhood and adolescence worldwide and has a significant association with mental health distress. However, there have been few studies that have examined the associations between any specific sub-type of sibling bullying and depression as well as anxiety. Besides, the association between sibling bullying and psychological well-being was never explored among the Chinese population.

Sex-specific influence of prenatal air pollutant exposure on neonatal neurobehavioral development and the sensitive window.

Increasing evidence indicates the adverse effect of air pollution exposure during pregnancy on neurologic development among children. However, the impact on neurobehavioral development in fetus remains unknown. In 2017, a total of 1193 mother-newborns pairs were enrolled in a birth cohort study in Changsha, China.

The prevalence of confirmed childhood trauma and its' impact on psychotic-like experiences in a sample of Chinese adolescents.

Adolescents with childhood trauma may be associated with psychotic-like experiences (PLEs) and is at high risk for later development of psychoses. Exploring early age risk factors for childhood trauma may provide useful information for prevention of mental disorders and improvement of mental health, yet no studies have examined the association between exposure to specific forms of trauma and different types of PLEs in a sample of Chinese adolescents. Thus, the Childhood Trauma Questionnaire-Short Form was used to measure five types of childhood trauma (emotional abuse, EA; physical abuse, PA; sexual abuse, SA; emotional neglect, EA; physical neglect, PA) in junior middle school students.

Identification of crucial genes and pathways associated with colorectal cancer by bioinformatics analysis.

Colorectal cancer (CRC) is a prevalent malignant tumour type arising from the colon and rectum. The present study aimed to explore the molecular mechanisms of the development and progression of CRC. Initially, differentially expressed genes (DEGs) between CRC tissues and corresponding non-cancerous tissues were obtained by analysing the GSE15781 microarray dataset.

Prognostic and clinicopathological significance of long non-coding RNA UCA1 in colorectal cancer: Results from a meta-analysis.

Objective: Urothelial cancer-associated 1 (UCA1), an oncogenic long non-coding RNA, was aberrantly upregulated in colorectal cancer (CRC). This study aimed to further explore the clinical value of UCA1 in CRC.

Methods: Eligible studies were retrieved by searching Pubmed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, and Wanfang databases.

Mitochondrial A3243G mutation causes mitochondrial encephalomyopathy in a Chinese patient: Case report.

Rationale: Mitochondrial mutations are associated with a wide spectrum of clinical abnormalities. More than half of these mutations are distributed in the 22 mitochondrial tRNA genes, including tRNA. In particular, the A3243G mutation in the tRNA gene causes mitochondrial encephalomyopathy.