Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study.

Background: The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.

Research Design And Methods: This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records.

Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease.

Skeletal muscle dysfunction (SMD), one of the extrapulmonary complications in patients with chronic obstructive pulmonary disease (COPD), considerably influences patient prognosis. Mitochondria regulates their dynamic networks through a mitochondria quality control (MQC) mechanism, involving mitochondrial biogenesis, mitochondrial dynamics, and mitophagy. The MQC is crucial for mitochondrial homeostasis and health, and disruption of it can lead to mitochondrial damage, which is a key factor in the structural and functional impairment of skeletal muscle in COPD.

Depression in middle-aged and older adults with hearing loss: the use and construction of a nomogram tool.

Objective: This study aims to explore the influencing factors of depressive symptoms in middle-aged and older adult patients with hearing loss and to construct a nomogram risk prediction model.

Methods: A total of 2,729 middle-aged and older adult patients with hearing loss from the community were selected as the study subjects. Single-factor and multifactorial stepwise logistic regression analyses were used to screen influencing factors.

Harnessing m1A modification: a new frontier in cancer immunotherapy.

N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers). This modification significantly impacts the function of RNA and various biological processes by affecting the structure, stability, translation, metabolism, and gene expression of RNA. Thereby, m1A modification is closely associated with the occurrence and progression of cancer.

Emerging two dimensional MXene for corrosion protection in new energy systems: Design and mechanisms.

With the development of new and clean energy (offshore wind power, fuel cells, aqueous zinc ion batteries, lithium-ion batteries, etc.), the corrosion and security problems in special environments of the new energy system have attracted much attention. Corrosion protection on the metals applied in new energy system can reduce the economic loss, security risk, and energy consumption, as well as guarantee the efficiency of energy system.

A novel tpp-like protein from Bacillus thuringiensis strain GXUN31-2 with nematicidal activity against Meloidogyne enterolobii.

The plant root-knot nematode Meloidogyne spp. is an endoparasite with worldwide distribution that is detrimental to the growth of a wide range of plants. The insecticidal crystal proteins produced by Bacillus thuringiensis are widely used as a biological insecticide to control Lepidopteran, Hemiptera, and Coleopteran pests.

Toward self-healing two dimensional MXene coatings for corrosion protection on metals: Design strategies and mechanisms.

Metallic corrosion leads to high economic losses and security risks, and coating protection is an effective approach to preventing metal from corrosion. However, defects such as cracks and micropores are inevitable in the coating, so it is urgent to develop self-healing coatings for realizing long-term corrosion protection due to the actively protective ability. Though two-dimensional (2D) transition metal carbide or nitride (MXene) coatings have been employed to realize self-healing function, the design strategies of the MXene-based coatings and mechanism on how MXenes inhibit corrosion at the coating-metal interface as well as the roles of MXene in self-healing process remain elusive.

Optimizing Reversible Phase-Transformation of FeS Anode via Atomic-Interface Engineering Toward Fast-Charging Sodium Storage: Theoretical Predication and Experimental Validation.

Sodium-storage performance of pyrite FeS is greatly improved by constructing various FeS-based nanostructures to optimize its ion-transport kinetics and structural stability. However, less attention has been paid to rapid capacity degradation and electrode failure caused by the irreversible phase-transition of intermediate NaFeS to FeS and polysulfides dissolution upon cycling. Under the guidance of theoretical calculations, coupling FeS nanoparticles with honeycomb-like nitrogen-doped carbon (NC) nanosheet supported single-atom manganese (SAs Mn) catalyst (FeS/SAs Mn@NC) via atomic-interface engineering is proposed to address above challenge.

Assessment of Personalized Exercise Prescriptions Issued by ChatGPT 4.0 and Intelligent Health Promotion Systems for Patients with Hypertension Comorbidities Based on the Transtheoretical Model: A Comparative Analysis.

Purpose: Exercise is a vital adjunct therapy for patients with hypertension comorbidities. However, medical personnel and patients face significant obstacles in implementing exercise prescription recommendations. AI has been developed as a beneficial tool in the healthcare field.

Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients.

Background: Breast cancer remains the leading malignant neoplasm among women globally, posing significant challenges in terms of treatment and prognostic evaluation. The metabolic pathway of polyamines is crucial in breast cancer progression, with a strong association to the increased capabilities of tumor cells for proliferation, invasion, and metastasis.

Methods: We used a multi-omics approach combining bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) to study polyamine metabolism.

Biological aging mediates the association between volatile organic compounds and cardiovascular disease.

Background: Evidence for the relationship between individual and combined volatile organic compounds (VOCs) and cardiovascular disease (CVD) is limited. Besides, the mediating role of biological aging (BA) has not been studied. Therefore, this study aimed to examine the association between VOCs and CVD risk and to explore the mediating effects of BA.

Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study.

Background: In previous observational studies and meta-analyses, childhood attention deficit hyperactivity disorder (ADHD) is found to have a significant association with screen time. However, the causal associations between them remain unclear.

Method: This study performed a bidirectional two-sample Mendelian randomization (MR) analysis to confirm the causality between screen time and childhood ADHD.

Trajectories of cognitive function development and predictive factors in disabled middle-aged and older adults.

Objective: To explore the trajectories of cognitive function development and predictive factors in disabled middle-aged and older adults.

Methods: Utilizing data from 983 disabled middle-aged and older adults in the China Health and Retirement Longitudinal Study (CHARLS) from 2013 to 2020, latent growth mixture models were constructed to analyze the categories of cognitive function development trajectories and their predictive factors.

Results: The cognitive function trajectories of the disabled middle-aged and older adults were classified into three categories: rapid decline (32.

Effect of carboxyl group on photoelectrochemical performance of TiOnanowire arrays for water splitting.

TiOis one of the most studied semiconductor materials for the photoelectrochemical water splitting to hydrogen production, but it only responds to ultraviolet light. The introduction of organic compound is one of the common means to expand the visible light response of TiO. In this work, rutile TiOnanowire arrays (NWs) were grown on conductive glass by a modified solvothermal method using oleic acid as the key additive.

Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals.

Acetogenic bacteria (acetogens) are a class of microorganisms with conserved Wood-Ljungdahl pathway that can utilize CO and CO/H as carbon source for autotrophic growth and convert these substrates to acetate and ethanol. Acetogens have great potential for the sustainable production of biofuels and bulk biochemicals using C1 gases (CO and CO) from industrial syngas and waste gases, which play an important role in achieving carbon neutrality. In recent years, with the development and improvement of gene editing methods, the metabolic engineering of acetogens is making rapid progress.

Case report: Symmetrical and increased lateral sway-based walking training for patients with corpus callosum infarction: a case series.

Introduction: Corpus callosum injury is a rare type of injury that occurs after a stroke and can cause lower limb dysfunction and a decrease in activities of daily living ability. Furthermore, there are no studies that focus on the progress in rehabilitation of the lower limb dysfunction caused by infarction in the corpus callosum and the effective treatment plans for this condition. We aimed to present a report of two patients with lower limb dysfunction caused by corpus callosum infarction after a stroke and a walking training method.

Mediating effect of adiponectin between free fatty acid and tumor necrosis factor-α in patients with diabetes.

Background/objectives: Increased free fatty acid (FFA) promotes adiponectin secretion in healthy subjects and induces inflammation in diabetes. Given the potential pro-inflammatory role of adiponectin in "adiponectin paradox", we performed this study in patients with type 2 diabetes mellitus (T2DM) to assess the association of FFA with adiponectin and to investigate whether adiponectin mediates FFA-related inflammation.

Methods: This cross-sectional study consisted of adult patients with T2DM.

Yield-related quantitative trait loci identification and lint percentage hereditary dissection under salt stress in upland cotton.

Salinity is frequently mentioned as a major constraint in worldwide agricultural production. Lint percentage (LP) is a crucial yield-component in cotton lint production. While the genetic factors affect cotton yield in saline soils are still unclear.

Alginate oligosaccharide assimilation by gut microorganisms and the potential role in gut inflammation alleviation.

Unlabelled: Dietary fiber metabolism by gut microorganisms plays important roles in host physiology and health. Alginate, the major dietary fiber of daily diet seaweeds, is drawing more attention because of multiple biological activities. To advance the understanding of alginate assimilation mechanism in the gut, we show the presence of unsaturated alginate oligosaccharides (uAOS)-specific alginate utilization loci (AUL) in human gut microbiome.

MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke.

Neuronal apoptosis is crucial in the pathophysiology of ischemic stroke (IS), albeit its underly24ing mechanism remaining elusive. Investigating the mechanism of neuronal apoptosis in the context of IS holds substantial clinical value for enhancing the prognosis of IS patients. Notably, the MRPS9 gene plays a pivotal role in regulating mitochondrial function and maintaining structural integrity.

Synergistically Coupling Atomic-Level Defect-Manipulation and Nanoscopic-Level Interfacial Engineering Enables Fast and Durable Sodium Storage.

Through inducing interlayer anionic ligands and functionally modifying conductive carbon-skeleton on the transition metal chalcogenides (TMCs) parent to achieve atomic-level defect-manipulation and nanoscopic-level architecture design is of great significance, which can broaden interlayer distance, optimize electronic structure, and mitigate structural deformation to endow high-efficiency battery performance of TMCs. Herein, an intriguing 3D biconcave hollow-tyre-like anode constituted by carbon-packaged defective-rich SnSSe nanosheet grafting onto Aspergillus niger spores-derived hollow-carbon (ANDC@SnSSe@C) is reported. Systematically experimental investigations and theoretical analyses forcefully demonstrate the existence of anion Se ligand and outer-carbon all-around encapsulation on the ANDC@SnSSe@C can effectively yield abundant structural defects and Na-reactivity sites, accelerate rapid ion migration, widen interlayer spacing, as well as relieve volume expansion, thus further resolving the critical issues throughout the charge-discharge processes.