Publications by authors named "Xiaoqing Ling"
Article Synopsis
- Researchers created a dual-hydrophobic drug conjugate, CPT-ss-DOX, which self-assembles into nanocubes for targeted colorectal cancer treatment.
- These PEGylated nanocubes improve the solubility, stability, and retention of the drugs, allowing for better accumulation at tumor sites and enhanced cancer cell toxicity compared to traditional drug mixtures.
- The study shows that these nanocubes not only inhibit tumor growth more effectively but also reduce cardiac toxicity, highlighting their potential for clinical use in cancer therapy.
Clustered regularly interspaced short palindromic repeat (CRISPR) system has been explored as an efficient tool for nucleic acid diagnostics. However, it normally needs instrumentation or produces turn-off signals. Herein, a bulged Y-shape DNA (Y-DNA) nanoassembly was designed and synthesized as a novel turn-on probe.
View Article and Find Full Text PDFRabies is a lethal encephalitis caused by the rabies virus (RABV) with a fatality rate near 100% after the onset of clinical symptoms in humans and animals. Microglia are resident immune cells in the central nervous system. Few studies have been conducted on the functional role of microglia in RABV infection.
View Article and Find Full Text PDFCottonseed hull, a low-cost widely available agricultural waste in China, after used as substrate for the white rot fungus Pleurotus ostreatus cultivation, was tested for the removal of Neutral Red (NR), a cationic dye, from aqueous solution. A batch adsorption study was carried out with varied solution pH, adsorbent dosage, reaction time and initial NR concentration. The results show that the kinetics of dye removal by the spent cottonseed hull substrate (SCHS) is prompt in the first 5 min and the adsorption equilibrium can be attained after 240 min.
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