Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp.

Phytochemical investigation of the stems of Mallotus paxii Pamp. led to the isolation and identification of four new compounds, including three neolignans (1-3) and one phenol (13), along with eight known neolignans (4-12) and one known phenol (14). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses.

Theoretical Study on the Electrocatalytic CO Reduction Mechanism of Single-Atom Co Complexed Carbon-Based (Co-N@C) Catalysts Supported on Carbon Nanotubes.

Electrocatalytic CO reduction serves as an effective strategy to tackle energy crises and mitigate greenhouse gas effects. The development of efficient and cost-effective electrocatalysts has been a research hotspot in the field. In this study, we designed four Co-doped single-atom catalysts (Co-N@C) using carbon nanotubes as carriers, these catalysts included tri- and dicoordinated N-doped carbon nanoribbons, as well as tri- and dicoordinated N-doped graphene, respectively denoted as H3(H2)-Co/CNT and 3(2)-Co/CNT.

Oleanane-type triterpenoids from Sabia limoniacea and their anti-inflammatory activities.

Eighteen new oleanane-type triterpenoids were isolated from the stems of Sabia limoniacea, including sabialimon A (1), a triterpenoid with an unprecedented 6/6/6/7/7 pentacyclic skeleton and seventeen undescribed triterpenoids, sabialimons B-R (2 - 18), along with six previously described analogs (19 - 24). Their structures were fully elucidated via extensive spectroscopic analysis including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), experimental electronic circular dichroism measurements and X-ray crystallographic studies. Compound 1 is the first triterpenoid that possesses a rare ring system (6/6/6/7/7) with an oxygen-bearing bridge between C-17 and C-18 and a hemiketal form at C-17, which is generated a larger ring by the degradation of C-28 and D/E-ring expansion.

Clinical Effect of Combined Fascia Sheath Suspension With Shortening Levator Muscle on Severe Blepharoptosis.

Objective: To study the clinical effect of conjoint fascial sheath (CFS) suspension and levator palpebrae superioris muscle shortening in the treatment of severe blepharoptosis.

Methods: Forty-five patients with severe blepharoptosis (75 eyes) from May 2020 to February 2022 in the authors' hospital were divided into 2 groups: group A (n = 33, 43 eyes) and group B (n = 24, 32 eyes). Group A was operated on by CFS + levator muscle shortening, and group B was operated on by frontal muscle flap suspension + levator muscle shortening.

Three megastigmane glycosides from the stem of .

Three undescribed megastigmane glycosides, mallbarbalosides A-C together with 3 known analogues were isolated from the stem of . Their structures were elucidated using extensive NMR spectroscopic methods (1D and 2D-NMR spectroscopy) and HRESIMS spectroscopic data analyses. The absolute configurations of the undescribed compounds were determined by the experimental circular dichroism spectroscopy.

Carbon emission potential of new energy vehicles under different electricity structures.

New energy vehicles have a significant impact on reducing green house gas (GHG) emissions in the transportation sector, but the ability of new energy vehicles to reduce emissions under various development scenarios and electricity energy mix needs to be studied in depth. In this research, a GRA-BiLSTM model is constructed to predict the ownership of new energy vehicles by three scenario settings. Then, the structure of the future energy generation is forecast using a regression model.

Feasibility for the application of expanded endoscopic resection criteria in mucosal undifferentiated gastric cancer.

Background & Aim: The indication of endoscopic submucosal dissection (ESD) for mucosal undifferentiated early gastric cancer (EGC) remains controversial because of risk of lymph node metastasis (LNM). The aim of this study was to identify risk factors for lymph node metastasis (LNM) in mucosal undifferentiated EGC, and further to confirm feasibility of the ESD for the treatment of mucosal undifferentiated EGC.

Methods: We retrospectively reviewed data of patients who underwent surgical resection with lymph node dissection of T1a stage primary gastric adenocarcinoma at three medical centers between 2012 and 2022.

Triterpenoids from the Leaves of and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.

Four new dammarane triterpenoid saponins cypaliurusides - (-) and eight known analogs (-) were isolated from the leaves of . The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit.

Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis.

Anastomotic leakage is a serious complication following gastrointestinal surgery and one of the leading causes of patient mortality. Despite the significant clinical and economic burden, there are currently no reliable treatment options to improve the healing of intestinal anastomosis and subsequently prevent anastomotic leakage. Recently, the development of regenerative medicine has shown promise for improving anastomotic healing.

Yeast cell templated porous hollow silica spheres for rapid hemostasis accompanied by antibacterial action.

Uncontrolled haemorrhage is the leading cause in nearly 91% of pre-hospital deaths, which were considered potentially survivable. In particular, severe trauma is susceptible to infection, which further affects the natural healing process and can even lead to life-threatening sepsis. Therefore, we established Ag@HMSN nanocomposites based on a yeast cell template that combines hemostasis with antibiosis and further studied the effects of different calcination temperatures on the hemostatic and antibacterial properties.

Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Dryand.

Two new triterpenoid glucosides, Heritiera A () and Heritiera B (), and six known triterpenoid analogs (-) were isolated from Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.

Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds.

Preventing arterial hemorrhage by intervening within the first few minutes is critical to the patient's life. Hemostatic materials have been developed over the last decades to address this issue, nevertheless these materials alone do not contribute to improve the survival effects in many extreme conditions, which is usually caused by penetrating arterial bleeding wounds that are incompressible and deep arterial bleeding with irregularly shapes. It is well known that, after calcium ion stimulation, many intriguing changes occurred in the major components of plasma, including the activation of several coagulation factors, such as the conversion of fibrinogen to fibrin, prothrombin to thrombin, and so on.

[Clinical Features and Prognosis of Patients with Castleman's Disease].

Objective: To analyze the clinical features and prognosis of patients with Castleman's disease (CD) and improve the diagnosis and treatment of CD.

Methods: Clinical data of patients diagnosed with CD by pathological biopsy in Gansu Provincial Hospital from January 2009 to November 2020 were retrospectively analyzed. According to clinical classification, the patients were divided into two groups: UCD (unicentric CD) group (=20) and MCD (multicentric CD) group (=9).

Megastigmane glycosides from Streblus ilicifolius (S.Vidal) Corner and their anti-inflammatory activity.

Twelve undescribed megastigmane glycosides, streilicifolosides A-L (1-12), together with 8 known analogues (13-21) were isolated from the leaves of Streblus ilicifolius (S.Vidal) Corner. Their plannar structures were elucidated using extensive NMR spectroscopic methods (1D and 2D-NMR spectroscopy), and HRESIMS spectroscopic data analyses.

Ultrasound examination of the normal fetal duodenum.

Objective: To use the fetal pylorus as a reference point to conveniently display the normal fetal duodenum by ultrasound.

Methods: This study was designed in cross-section. A total of 450 healthy singleton pregnant women at 19-39 weeks of gestation who underwent prenatal screening at our hospital from January 2019 to February 2020 were selected.

Theoretical Study of Hydrogen Production from Ammonia Borane Catalyzed by Metal and Non-Metal Diatom-Doped Cobalt Phosphide.

The decomposition of ammonia borane (NHBH) to produce hydrogen has developed a promising technology to alleviate the energy crisis. In this paper, metal and non-metal diatom-doped CoP as catalyst was applied to study hydrogen evolution from NHBH by density functional theory (DFT) calculations. Herein, five catalysts were investigated in detail: pristine CoP, Ni- and N-doped CoP (CoP), Ga- and N-doped CoP (CoP), Ni- and S-doped CoP (CoP), and Zn- and S-doped CoP (CoP).

Lactate-driven macrophage polarization in the inflammatory microenvironment alleviates intestinal inflammation.

Background: Lactate has long been considered an intermediate by-product of glucose metabolism. However, in recent years, accumulating evidence reveals that lactate has unique biological activities. In previous studies, lactate signaling was shown to inhibit inflammation.

Quaternary Ammonium-Tethered Phenylboronic Acids Appended Supramolecular Nanomicelles as a Promising Bacteria Targeting Carrier for Nitric Oxide Delivery.

The delivery of drugs to focal sites is a central goal and a key challenge in the development of nanomedicine carriers. This strategy can improve the selectivity and bioavailability of the drug while reducing its toxicity. To ensure the specific release of nitric oxide at the site of a bacterial infection without damaging the surrounding normal tissue, we designed a host-guest molecule containing a host molecule with a target moiety and a nitric oxide donor to release nitric oxide.

Comprehensive Treatment of Lower Eyelid Plasty Based on Intraoral Fixation and Redistribution of Lower Eyelid Fat.

Background: Eye bags especially give an impression of aging and mental exhaustion. At present, the surgical methods of bags mainly include conjunctival approach and lower eyelid skin approach. With the continuous upgrading of the concept of facial esthetics, the lower eyelid pouch surgery for middle-aged and elderly patients pays more attention to reducing surgical trauma, improving tear trough deformity along with the effacement of lid‑cheek junction.

Two new terpenoid glycosides from .

One previously undescribed tricyclo-diterpenoid saponin (), one undescribed dammarane triterpenoid saponin () and four known triterpenoids (-) were isolated from the aerial part of Their structures were determined using 1 D- and 2 D-NMR, HRESIMS, and comparison of their spectroscopic data with previously reported data. The isolates were evaluated for their anti-HBV activity using the HBV transfected Hep G2.2.

Microscopic mechanism of light-induced tetrazole-quinone 1,3-dipolar cycloaddition: a MS-CASPT2 theoretical investigation.

Recently, experimentalists have developed a green and efficient method to synthesize pyrazole-fused quinones through light-induced tetrazole-quinone 1,3-dipole cycloadditions. However, the underlying microscopic mechanisms remain to be clarified. In this work, we have employed several electronic structure calculation methods (MS-CASPT2, CASSCF, DFT) to systematically explore the microscopic mechanism of related light-induced reactions and deactivation pathways.

Effect of exercise on bone mineral density among patients with osteoporosis and osteopenia: A systematic review and network meta-analysis.

Aims And Objectives: To systematically review and compare the efficacy of different exercise interventions on bone mineral density (BMD, g/cm ) in patients with osteoporosis and osteopenia.

Background: It is vitally important to prevent and treat bone loss in patients with osteoporosis and osteopenia. Exercise can effectively increase bone density and slow down bone loss in middle-aged and older people.