Publications by authors named "Xiaoqiao Xu"
Osteoporosis, a prevalent disease characterized by low bone density and increased fracture risk, poses significant health challenges for the elderly. Current treatments offer short-term benefits but are limited by long-term efficacy and adverse effects, highlighting the need for new strategies. Chondroitin sulfate polysaccharides (CS), a major component of the bone matrix, are crucial for bone and cartilage health.
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- Scientists studied lung cells from healthy human fetuses to learn how lungs develop and how diseases can affect them.
- They found different types of lung cells that come from special starting cells which have a key protein called CFTR.
- This research helps create a detailed map of how human lungs grow, which could help in understanding and treating lung diseases.
Mammalian teeth, developing inseparable from epithelial-mesenchymal interaction, come in many shapes and the key factors governing tooth morphology deserve to be answered. By merging single-cell RNA sequencing analysis with lineage tracing models, we have unearthed a captivating correlation between the contrasting morphology of mouse molars and the specific presence of PRX1 cells within M1. These PRX1 cells assume a profound responsibility in shaping tooth morphology through a remarkable divergence in dental mesenchymal cell proliferation.
View Article and Find Full Text PDFObjectives: The aim of this research was to investigate the functions of Piezo channels in dentin defect, including mechanical signalling and odontoblast responses.
Methods: Rat dentin-defect models were constructed, and spatiotemporal expression of Piezo proteins was detected in the pulpo-dentinal complex. Real-time polymerase chain reaction (rtPCR) was used to investigate the functional expression pattern of Piezo channels in odontoblasts.
Article Synopsis
- Growing children's growth plate cartilage has limited self-repair, often leading to growth issues after fractures, but some fractures exhibit exceptional self-healing.
- * Researchers identified that Hedgehog (Hh) signaling is activated in a specific type of fracture, which helps stimulate chondrocytes and promotes cartilage repair.
- * The study highlights the essential role of primary cilia in transmitting Hh signals and indicates that enhancing this signaling pathway can accelerate growth plate recovery after injuries.
Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and supernumerary teeth. Tooth development is regulated by numerous developmental signals, such as the well-known Wnt, BMP, FGF, Shh and Eda pathways, which mediate the ongoing complex interactions between epithelium and mesenchyme. Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number; however, the underlying mechanisms remain elusive.
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- The study investigates the effectiveness of a combined assessment system using mini clinical evaluation exercises (mini-CEX) and objective structured clinical examinations (OSCE) to evaluate postgraduate clinical competence in dentistry in China, where these evaluations are primarily focused on undergraduates.
- Results indicate significant improvement in the comprehensive clinical competence of postgraduates in prosthodontics after undergoing the modified mini-CEX/OSCE evaluations, showing higher progress compared to other dental masters.
- Overall, the modified evaluation system was found to be a reliable and effective tool for enhancing clinical skills and satisfaction among postgraduate students in residency training programs.
Neural crest-derived mesenchymal stem cells (MSCs) are known to play an essential function during tooth and skeletal development. PRX1 cells constitute an important MSC subtype that is implicated in osteogenesis. However, their potential function in tooth development and regeneration remains elusive.
View Article and Find Full Text PDFBackground: Risky behaviors can lead to huge economic and health losses. However, limited efforts are paid to explore the genetic mechanisms of risky behaviors.
Result: MASH analysis identified a group of target genes for risky behaviors, such as APBB2, MAPT and DCC.