Publications by authors named "Xiaoqiang Liu"

Article Synopsis
  • * The review covers different sources of electrical stimulation and the best electrode materials suited for clinical applications, discussing their biological impacts on cells and tissues.
  • * Future developments will focus on improving equipment performance and meeting clinical needs, emphasizing the importance of safety, feasibility, and cost-effectiveness in these technologies.
View Article and Find Full Text PDF

Background: Metastatic prostate cancer (mPCa) complicates treatment due to its unpredictable progression. Current prognostic tools often lack precision. This study aimed to develop an effective tool to predict overall survival (OS) in mPCa patients undergoing radiotherapy, thereby addressing the clinical need for personalized treatment decisions.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates how different types and frequencies of beverage consumption relate to erectile dysfunction (ED) in American men, using data from the NHANES 2003-2004.
  • The results showed that men who consume grape juice regularly (5 or more times a week) had a significantly lower likelihood of experiencing ED, especially in those over 40 years old.
  • While grape juice was the most notable beverage linked to reduced ED prevalence, other beverages like tomato, orange, and soft drinks also showed initial correlations with ED.
View Article and Find Full Text PDF

Background: Individual antioxidants may not fully capture the comprehensive antioxidant intake from an individual's diet. This study utilizes the Complex Dietary Antioxidant Index (CDAI) to evaluate the combined effects of various dietary antioxidants in the diet. The goal is to investigate the relationship between CDAI and the incidence of erectile dysfunction (ED), offering insights for dietary guidelines and intervention strategies aimed at mitigating the burden of ED.

View Article and Find Full Text PDF

Objective: This study was designed to conduct data mining through the Food and Drug Administration Adverse Event Reporting System (FAERS) to assess adverse events (AEs) associated with cabozantinib in the treatment of renal cell carcinoma.

Methods: Reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS) algorithms were used to detect drug-related AEs signals from reporting data in FAERS database from 2016 to 2024.

Results: A total of 32,129 AE reports identifying cabozantinib as a 'primary suspect' were retrieved from the FAERS database.

View Article and Find Full Text PDF

Flupyrimin (FLP) is a novel class of insecticide acting on insect nicotinic acetylcholine receptor (nAChR) and shows robust insecticidal activity. However, the toxicological effects of FLP on Spodoptera litura have not been revealed. In this study, the results showed that the larval survival rate decreased significantly with increasing concentration of FLP.

View Article and Find Full Text PDF

Background: We aimed to use Mendelian randomization (MR) to determine the causality between fifteen major mental disorders (MDs) and benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis.

Methods: The main MR analysis was performed using the inverse variance-weighted (IVW) method.

Results: The study found that insomnia (odds ratio [OR], 1.

View Article and Find Full Text PDF

An ultrasensitive electrochemical sensor is constructed by electrostatically adsorbing negatively charged hourglass-shape Cu-Polyoxometalate (POM) onto a positively charged CoO nanowires modified carbon cloth. The petaloid CoO nanowires have a large specific surface area that can well disperse open-structured Cu-POM to form Cu-POM@CoONWs@CC, which can maximumly expose catalytic active centers (Co and Cu) and accelerate mass/charge transfer. In addition to the above advantages, the excellent electron exchange ability of Cu-POM and good conductivity of CoONWs@CC endow the sensor with good detection capability to HO including a linear detection range of 0.

View Article and Find Full Text PDF
Article Synopsis
  • * The study involved 253 RCC patients and utilized various methods including cell proliferation analysis and Cox regression to assess the impact of miR-190a-5p on cancer prognosis and characteristics.
  • * Findings suggest that increasing the levels of miR-190a-5p can inhibit cancer cell proliferation and invasiveness by targeting a gene called GDF11, thus highlighting its regulatory role in RCC progression.
View Article and Find Full Text PDF
Article Synopsis
  • * Two subtypes of BLCA tied to cell differentiation were identified; one subtype had a better prognosis while the other showed a high level of immune cell infiltration.
  • * The research established a CDR scoring system linked to survival outcomes, revealing that higher scores correlate with worse prognosis and suggesting ANXA5 as a potential therapeutic target for customized treatment approaches.
View Article and Find Full Text PDF
Article Synopsis
  • - Non-obstructive azoospermia (NOA) is a significant cause of male infertility, and this study aimed to discover new biomarkers for its diagnosis and prognosis using existing data.
  • - Researchers analyzed NOA datasets from the Gene Expression Omnibus (GEO), identifying hub genes through various methods, including machine learning and protein interaction networks, with results validated through external datasets.
  • - Two specific immune-related hub genes were found to be highly expressed in NOA patients, showing strong predictive ability for diagnosis and indicating their involvement in significant biological pathways; potential therapies and regulatory networks were also suggested.
View Article and Find Full Text PDF
Article Synopsis
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant human pathogen linked to various infections, and gut microbiota, particularly spermidine, plays a crucial role in this context.
  • Research demonstrated that spermidine has protective benefits against MRSA bloodstream infections in mice by reducing bacterial load and inflammation, shifting macrophages to an anti-inflammatory state.
  • The study found that spermidine's protective effects are associated with increased expression of protein tyrosine phosphatase nonreceptor 2 (PTPN2), suggesting potential new treatment strategies for MRSA-related infections.
View Article and Find Full Text PDF

Introduction: Antidepressants may lead to a series of sexual adverse effects (SAEs), among which ejaculation dysfunction (EjD) is often overlooked by clinicians. The purpose of the present network meta-analysis was to assist drug adjustment by comparing and ranking the incidence of EjD among various antidepressants.

Methods: Relevant studies were retrieved from PubMed, Embase, Scopus, Web of Science, ClinicalTrials.

View Article and Find Full Text PDF

PANoptosis has been shown to play an important role in tumorigenesis and gain more attention. Yet, the prognostic significance of PANoptosis-related genes has not been investigated more in clear cell renal cell carcinoma (ccRCC). The aim of this research was designed to identify and create a signature of PANoptosis-related genes which was expected to predict prognosis of ccRCC more effectively.

View Article and Find Full Text PDF
Article Synopsis
  • - The study aims to assess the risks associated with enfortumab vedotin (EV) for advanced bladder cancer using real-world data from the FDA's adverse event reporting system (FAERS) from early 2020 to early 2024.
  • - Researchers conducted a detailed analysis of 7,449,181 FAERS case reports, identifying 1,617 EV-related adverse drug events (ADEs) and finding significant safety signals for rare conditions like lichenoid keratosis and small intestinal perforation.
  • - The results mostly matched existing safety data, highlighting the importance of ongoing clinical monitoring for EV-related ADEs and the need for further research to confirm the newly discovered risks.
View Article and Find Full Text PDF

In this work, a horseradish peroxidase (HRP)-encapsulated metal organic framework (MOF)@MOF nanocomposite is developed for detecting HO converted by dismutation of superoxide anions released from live HeLa mitochondria. Initially, an HRP-polyacrylic acid cluster is incorporated on a mesoporous, peroxidase-like Cu/Co-1,4-benzenedicarboxylate (BDC) MOF platform to avoid structural change and deactivation of HRP through its interactions with MOF metal ions. Additionally, a Cu/Co-BDC(HRP)@1,3,5-benzenetricarboxyate (BTC) core-shell MOF/MOF structure, also with peroxide-like properties, serves as a protective matrix for HRP.

View Article and Find Full Text PDF

Background: The risk stratification for fatal arrhythmias remains inadequate. Cardiac magnetic resonance (CMR) imaging provides a detailed evaluation of arrhythmogenic substrates. This study investigated the predictive capacity of multiparametric CMR for fatal ventricular arrhythmias (VAs) in a heterogeneous disease cohort.

View Article and Find Full Text PDF
Article Synopsis
  • The text refers to a correction made to a previously published article in a scientific journal.
  • The DOI provided (10.1021/acsomega.3c08594) identifies the specific article that has been corrected.
  • Corrections in academic publishing are important to ensure the integrity and accuracy of the research presented.
View Article and Find Full Text PDF

Statement Of Problem: Robotic systems have shown promise for implant placement because of their accuracy in identifying surgical positions. However, research on the accuracy of patient calibration methods based on cone beam computed tomography (CBCT) and intraoral scanner (IOS) data registration is lacking.

Purpose: The purpose of this in vitro study was to develop a calibration method based on the registration of CBCT and IOS data of a robot-assisted system for implant placement, evaluate the accuracy of this calibration method, and explore the accuracy of robot-assisted surgery at different implant positions.

View Article and Find Full Text PDF

Objective: This study evaluates the relationship between the Life's Essential 8 (LE8) scoring system and all-cause and cause-specific mortality among obese individuals using National Health and Nutrition Examination Survey data.

Methods: Data from 9143 obese participants (BMI ≥30 kg/m) collected between 2005 and 2018 were analyzed. Participants were categorized based on their LE8 scores: low cardiovascular health (Low CVH, n = 2264), moderate cardiovascular health (Moderate CVH, n = 6541), and high cardiovascular health (High CVH, n = 338).

View Article and Find Full Text PDF

Statement Of Problem: Crown lengthening surgery has been widely used to enhance the health and esthetics of anterior teeth, and its accuracy significantly influences surgical outcomes. However, the feasibility and accuracy of a robot system for crown lengthening surgery remains unknown.

Purpose: The purpose of this in vitro study was to develop a crown lengthening surgery robot and evaluate its accuracy.

View Article and Find Full Text PDF

Background emergence of multidrug-resistant (MDR) bacterial strains is a public health concern that threatens global and regional security. Efflux pump-overexpressing MDR strains from clinical isolates are the best subjects for studying the mechanisms of MDR caused by bacterial efflux pumps. A strain overexpressing the OqxB-only efflux pump was screened from a clinical strain library to explore reverse OqxB-mediated bacterial resistance strategies.

View Article and Find Full Text PDF

Due to the multiple influences of unique physicochemical properties of helium, petrographic characteristics and temperature and pressure conditions, little is known about the helium adsorption behaviors in minerals and rocks at geological conditions. Based on the grand canonical Monte Carlo simulations, this study revealed the adsorption characteristics of pure helium and the competitive adsorption of binary mixtures with different proportions of methane and helium under geological temperature and pressure conditions in quartz slit model. Molecular simulation of pure helium shows that physical adsorption of helium exists in mineral surfaces, which indicates a preservation mechanism of helium in helium source rocks.

View Article and Find Full Text PDF

Although the anaerobic reduction of azo dyes is ecofriendly, high ammonia consumption remains a significant challenge. This work enriched a mixed nitrogen-fixing bacteria consortium (NFBC) using n-FeO to promote the anaerobic reduction of methyl orange (MO) without exogenous nitrogen. The enriched NFBC was dominated by Klebsiella (80.

View Article and Find Full Text PDF