A comprehensive investigation of the adsorption behaviour and mechanism of industrial waste sintering and bayer red muds for heavy metals.

The issue of heavy metal pollution is a critical global concern that requires urgent solution. However, conventional heavy metal adsorbents are too costly to be applied in large-scale engineering. In this study, adsorption behavior and mechanism of sintering red mud (RM-A) and bayer red mud (RM-B) for heavy metals were investigated to address the disposal of red mud as industrial waste and remediation of heavy metal pollution.

Research Enhancing Acidic Mine Wastewater Purification: Innovations in Red Mud-Loess.

This study investigates the adsorption of cadmium (Cd) by red mud-loess mixed materials and assesses the influence of quartz sand content on permeability. Shear tests are conducted using various pore solutions to analyze shear strength parameters. The research validates solidification methods for cadmium-contaminated soils and utilizes SEM-EDS, FTIR, and XRD analysis to elucidate remediation mechanisms.

Interpretable machine learning model to predict surgical difficulty in laparoscopic resection for rectal cancer.

Background: Laparoscopic total mesorectal excision (LaTME) is standard surgical methods for rectal cancer, and LaTME operation is a challenging procedure. This study is intended to use machine learning to develop and validate prediction models for surgical difficulty of LaTME in patients with rectal cancer and compare these models' performance.

Methods: We retrospectively collected the preoperative clinical and MRI pelvimetry parameter of rectal cancer patients who underwent laparoscopic total mesorectal resection from 2017 to 2022.

Large-scale laboratory investigation of the performance of a novel isolation particle layer for offshore final disposal sites.

The complex seabed conditions and ocean environment pose significant challenges to the material selection and construction of bottom liners for offshore final disposal sites. To overcome the challenges, this study proposed a novel isolation particle layer for offshore final disposal sites. The isolation particle was composed by salt-resistant bentonite coating material and cement core material (D10 was 10 mm in core diameter and 2 mm in coating thickness; D20 was 20 mm and 4 mm).

Synergistic utilization of industrial waste red mud and rice husk ash for eco-friendly geopolymer preparation: enhancing strength and mitigating hazardous leaching.

The prolonged stacking of substantial volumes of industrial waste red mud (RM) can have significantly hazardous effects on the environment. In order to address this critical problem, this study proposes the synergistic preparation of geopolymers utilizing RM in conjunction with another industrial waste, rice husk ash (RHA). Geopolymers with varying incorporation of RHA were prepared using sodium hydroxide and sodium silicate composite alkaline activator.

Role of LncRNA MIR99AHG in breast cancer: Bioinformatic analysis and preliminary verification.

Objective: This research was aimed to preliminarily explore the clinical roles and potential molecular mechanisms of MIR99AHG and its significant transcripts in breast cancer (BRCA).

Methods: Public databases were utilized to analyze the expression and prognostic roles of MIR99AHG and its transcripts. Relationships between MIR99AHG expression and immune cells infiltration were analyzed in Xiantao platform.

Remediation of lead-contaminated groundwater by oyster shell powder-peanut shell biochar mixture.

Groundwater pollution caused by lead ions has become a widespread issue worldwide due to the ever-increasing development of industrial activities. Such pollution poses significant threats to both humans and the environment. Oyster shell powder-peanut shell biochar mixture (OSP-PSB mixture) was used for lead-contaminated groundwater treatment by permeable reactive barrier (PRB) technology.

Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer.

Epigenetic alterations have essential roles during colon adenocarcinoma (COAD) progression. As the coactivator of Wnt/b-catenin signaling, Pygopus 2 (Pygo2) binds H3K4me2/3 and participate in chromatin remodeling in multiple cancers. However, It remains unclear whether the Pygo2-H3K4me2/3 association has significance in COAD.

Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases.

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range of pharmacological activities.

Heavy metal stabilization remediation in polluted soils with stabilizing materials: a review.

The remediation of soil contaminated by heavy metals has long been a concern of academics. This is due to the fact that heavy metals discharged into the environment as a result of natural and anthropogenic activities may have detrimental consequences for human health, the ecological environment, the economy, and society. Metal stabilization has received considerable attention and has shown to be a promising soil remediation option among the several techniques for the remediation of heavy metal-contaminated soils.

PLAGL1 is associated with prognosis and cell proliferation in pancreatic adenocarcinoma.

Background: Emerging evidence has shown the crucial roles of pleomorphic adenoma gene (PLAG) family genes in multiple cancers. However, their functions and mechanisms in pancreatic adenocarcinoma (PAAD) remain poorly understood.

Methods: We analyzed the expression levels of PLAG family genes in both The Cancer Genome Atlas (TCGA) database and a Gene Expression Omnibus (GEO) database, and confirmed the results in our three independent cohorts of 382 PAAD tissues and 362 adjacent nontumor pancreatic tissues.

BRD9 is an essential regulator of glycolysis that creates an epigenetic vulnerability in colon adenocarcinoma.

Background: The intensive interplay between aberrant epigenetic events and metabolic remodeling represents one of the hallmarks of tumors, including colon cancer. The functions of Bromodomain Containing Protein BRD-9 in colon cancer remains indefinite. We aimed to identify the biological roles and clinical significance of BRD9 in colon cancer.

TOX3 regulates the proliferation and apoptosis of colorectal cancer by downregulating RhoB via the activation of the MAPK pathway.

TOX high mobility group box family member 3 (TOX3) can function as tumor suppressor or oncogene in different tumors, while ras homolog family member B (RhoB) is a well-known tumor suppressor. The expression and role of TOX3 in colorectal cancer (CRC) are unknown. This study aimed to investigate the expression of TOX3 in CRC and the role of TOX3/mitogen-activated protein kinase (MAPK)/RhoB signaling in the proliferation and apoptosis of CRC cells.

Study on the Mechanical and Leaching Characteristics of Permeable Reactive Barrier Waste Solidified by Cement-Based Materials.

The durability against wet-dry (w-d) cycles is an important parameter for the service life design of solidified permeable reactive barrier (PRB) waste. This study introduces the potential use of cement, fly ash, and carbide slag (CFC) for the stabilization/solidification (S/S) of PRB waste. In this study, solidified PRB waste was subjected to different w-d cycles ranging in times from 0 to 10.

Long Non-Coding RNA Facilitates Cell Proliferation and Induces Apoptosis in Colorectal Cancer via miR-519b/ZNF277 Axis.

Introduction: Long non-coding RNAs (LncRNAs) play a critical role in development and progression of various cancers. More and more researchers pay attention to the effect of lncRNA on regulating the cancer. However, the function and mechanism of in colorectal cancer have not been studied.

The Effects of Fiber Inclusion on the Evolution of Desiccation Cracking in Soil-Cement.

Desiccation cracking frequently occurs in mud, clay, and pavement. Understanding the evolution of desiccation cracking may facilitate the development of techniques to mitigate cracking and even prevent it from developing altogether. In this study, experimental investigations were performed focusing on the effects of fibers on the evolution of desiccation cracking in soil-cement.

MicroRNA miR-29a Inhibits Colon Cancer Progression by Downregulating B7-H3 Expression: Potential Molecular Targets for Colon Cancer Therapy.

MiR-29a belongs to one of the subtypes of miRNAs known as non-coding single-stranded RNAs and is preferentially expressed in normal tissues. B7-H3, a member of the B7/CD28 immunoglobulin superfamily, was shown to be overexpressed in several solid malignant tumors, including colon cancer. In addition, it is associated with tumor progression and poor prognosis.

Particle hydrodynamic simulation of thrombus formation using velocity decay factor.

Background And Objective: Thrombus simulation plays an important role in many specialist areas in the field of medicine such as surgical education and training, clinical diagnosis and prediction, treatment planning, etc. Although a considerable number of methods have been developed to simulate various kinds of fluid flows, it remains a non-trivial task to effectively simulate thrombus because of its unique physiological properties in contrast to other types of fluids. To tackle this issue, this study introduces a novel method to model the formation mechanism of thrombus and its interaction with blood flow.

An Electrical Resistivity Method of Characterizing Hydromechanical and Structural Properties of Compacted Loess During Constant Rate of Strain Compression.

Hydromechanical and structural properties of compacted loess have a significant impact on the stability and reliability of subbase and subgrade, which needs to be quickly determined in the field and laboratory. Hence, an electrical resistivity method was used to characterize the hydromechanical and structural properties of compacted loess during constant rate of strain compression. In the present work, compacted loess samples with a dry density of 1.

Autophagy-related genes prognosis signature as potential predictive markers for immunotherapy in hepatocellular carcinoma.

Autophagy-related genes (ATGs) depress tumorigenesis. However, in tumor tissue, it promotes tumor progression. Here, we demonstrated that 63 ATGs were differentially expressed in normal tissues and tumor tissues of hepatocellular carcinoma (HCC), and seven prognostic-related genes were chosen to establish prognostic risk signatures.

Interleukin‑37 is increased in peripheral blood mononuclear cells of coronary heart disease patients and inhibits the inflammatory reaction.

It has been universally acknowledged that interleukin‑37 (IL‑37) has an immunosuppressive effect on various inflammatory disorders. However, whether IL‑37 participates in the acute inflammation associated with coronary heart disease (CHD) has not yet been clarified. In the present study, the association between the serum levels of IL‑37 and the clinical indexes of CHD were analysed.

Long Noncoding RNA GM16343 Promotes IL-36β to Regulate Tumor Microenvironment by CD8T cells.

Objective: To investigate the effect of long noncoding RNA GM16343 on interleukin 36β promotion of CD8T cells in tumor microenvironment regulation.

Methods: The differentially expressed long noncoding RNA in interleukin 36β-stimulated mouse CD8T cells was screened by gene chip technology, and the significant differentially expressed long noncoding RNAs were verified by real-time polymerase chain reaction. The lentiviral vector that overexpresses or knockdown GM16343 was constructed, transfected into CD8T cells, and stimulated with interleukin 36β, and the amount of interferon γ secreted was detected by enzyme-linked immunosorbent assay.

IL-9 Exerts Antitumor Effects in Colon Cancer and Transforms the Tumor Microenvironment .

As a newly discovered cytokine, interleukin 9 was initially considered a T-lymphocyte growth factor. Interleukin 9 affects target cells by binding to a member of the γc-family of receptors and is involved in inflammation, autoimmune diseases, and other ailments. In recent years, mounting evidence reveals that interleukin 9 exerts antitumor effects, which has attracted considerable attention.