Publications by authors named "Xiaoqian Jiao"
Article Synopsis
- Nucleoside analogs are the main antiviral drugs used for treating feline herpesvirus-1 (FHV-1), but they face issues like drug resistance and a limited mechanism of action.
- This research highlights the need for new antiviral drugs and investigates natural compounds that can effectively target the virus's glycoprotein B (gB) using techniques like Bio-layer interferometry (BLI).
- The study found that compounds Saikosaponin B2, Punicalin, and Punicalagin demonstrated strong antiviral effects against FHV-1 without being toxic to cells, particularly by preventing the virus from entering cells in the early stages of infection.
Antibiotic therapy effectively addresses -induced enteric diseases, but its excessive utilization results in microbial imbalance and heightened resistance. This study evaluates the therapeutic efficacy of orally administered poly (lactic-co-glycolic acid) (PLGA)-loaded antimicrobial peptide OH-CATH30 microspheres in murine bacterial enteritis. Mice were categorized into the healthy control group (CG), untreated model group (MG), OH-CATH30 treatment group (OC), PLGA-OH-CATH30 treatment group (POC), and gentamicin sulfate treatment group (GS).
View Article and Find Full Text PDFBacterial keratitis in animals presents challenges due to ocular structural barriers, hindering effective drug delivery. In this study, we used biocompatible and biodegradable poly(lactic-co-glycolic acid) (PLGA) to encapsulate the naturally occurring antimicrobial peptide OH-CATH30, an alternative to conventional antibiotics, for the treatment of bacterial keratitis in animals. Microspheres (MS) were prepared using a modified water-in-oil-in-water (W/O/W) double-emulsion method with optimized osmotic pressure.
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