Diffuse skin erythematous plaque as a manifestation of epithelioid hemangioendothelioma: A case report.

Epithelioid hemangioma (EHE) is a rarely malignant tumor originating from the vascular endothelium. Morphological manifestations and immunohistochemical staining results are key to diagnosing EHE. Herein, we present a case of cutaneous involment in a recurrence of EHE.

Discovery of the Next-Generation Platinum-Based Anticancer Agents for Combating Oxaliplatin-Induced Drug Resistance.

Oxaliplatin-based chemotherapy has proven to be one of the most effective treatments for advanced or metastatic colorectal cancer. However, increasing clinical resistance to oxaliplatin poses unprecedented challenges for both patients and clinicians. Despite extensive efforts to combat this issue, to date, no new molecules have been discovered that can successfully replace oxaliplatin.

The mechanism and application of computer-assisted full facial skin imaging systems.

Computer-assisted full facial imaging systems are currently among the most widely used skin analysis instruments in dermatology and medical cosmetology. These systems offer objective quantitative evaluation of facial skin conditions, and as they are non-invasive, play an important role in assessing dermatological conditions such as pigmentation, inflammation, vascular diseases, skin texture, the severity of ageing, and therapeutic follow-up. Although computer-assisted full facial imaging systems enable quantitative analysis in the scope of medical treatment and cosmetic evaluation, their results may considerably vary because of the influence of environmental and postural factors for improper operation.

Relationship Between Dermoscopic Capillary-Related Features of the Auricle and Earlobe and Rosacea Subtype and Disease Severity: A Cross-Sectional Analysis.

Background And Aim: Clinical manifestations of rosacea include transient or persistent facial erythema, telangiectasia, papules, and pustules. The existing assessment tools primarily evaluate the facial area to assess the severity of rosacea. However, in addition to the face, telangiectasia, erythema, and flushing can occur in the ear.

Predictive Ability of European Heart Surgery Risk Assessment System II (EuroSCORE II) and the Society of Thoracic Surgeons (STS) Score for in-Hospital and Medium-Term Mortality of Patients Undergoing Coronary Artery Bypass Grafting.

Objective: To evaluate the powers of European Heart Surgery Risk Assessment System II (EuroSCORE II) and the Society of Thoracic Surgeons (STS) score in predicting in-hospital and medium-term mortality of patients undergoing coronary artery bypass grafting (CABG).

Methods: Totally 1628 Chinese patients were included between January 2000 and January 2018. Their perioperative clinical data were collected and the patients were closely followed up.

The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1.

Background: Comprehensive bioinformatics analysis of the effective molecular screening of Podophyllum octagonal in breast cancer treatment by using network pharmacology.

Methods: We collected the active ingredients and target genes of Chinese medicine octagonal lotus through the Traditional Chinese Medicine System Pharmacology Analysis Platform (TCMSP); downloaded human protein annotation information on the protein database Uniport; and collected data from five databases: GeneCards, OMIM, PharmGkb, TDD, and DrugBank. Construct the practical ingredient-target gene data intersection to obtain the target gene-disease gene and draw the Venn diagram.

Effects of peak time of myocardial injury biomarkers on mid-term outcomes of patients undergoing OPCABG.

Background: With the development of cardiac surgery techniques, myocardial injury is gradually reduced, but cannot be completely avoided. Myocardial injury biomarkers (MIBs) can quickly and specifically reflect the degree of myocardial injury. Due to various reasons, there is no consensus on the specific values of MIBs in evaluating postoperative prognosis.

Developing the relationship between metal ionic characters and ecological risk assessment screening values using QICAR.

Metals are widely released and distributed in soil and may have a negative impact on terrestrial organisms. Over the past years, a series of criteria or standards for assessing the ecological risks and toxicity of metals have been published in many countries; however, few studies have investigated their metal ionic properties and toxicity. In the present study, the ecological risk assessment screening values (ERASV) recommended by the Oregon Department of Environmental Quality were selected to investigate the correlation between metal toxicity and their ionic characters based on the hard and soft acids and bases (HSAB) concept.

Dopamine-assisted one-pot synthesis of gold nanoworms and their application as photothermal agents.

Gold-based nanomaterials of various sizes and geometries have been prepared for use as photothermal agents due to their unique physical and chemical properties. Here we report a simple one-step synthesis of gold nanoworms (NWs) and characterized them with transmission electron microscopy, X-ray photoelectron spectroscopy, UV-Visible spectroscopy, and Fourier transform infrared spectroscopy. The results showed that small gold nanounits were first formed by reducing chloroaurate ions (AuCl) with sodium borohydride (NaBH), and then fused together to form NWs assisted by dopamine (DA), which served a structure-director due to an oriented attachment mechanism.

Quantifying correlations of metal ionic characters with ecological soil screening levels (Eco-SSLs) of metals using QICAR models.

Soil pollution by heavy metals is a major challenge for soil ecosystems; therefore, many countries have published thresholds or standards for protecting soil organisms based on toxicity testing. However, there have been few studies on the mechanism of metal toxicity on organisms in soils, especially relationships between metal's ionic properties and its toxicity. Herein, we selected environmental soil screening levels (Eco-SSLs), which are internationally recognized ecotoxicity values recommended by the United States Environmental Protection Agency (USEPA), and investigated relationships between Eco-SSLs and metal ionic characteristics.

Development of a coupled model of quantitative ion character-activity relationships-biotic ligand model (QICARs-BLM) for predicting toxicity for data poor metals.

The biotic ligand model (BLM) is proposed as a tool to quantitatively evaluate biological toxicity of metals considering both metal speciation and the influence of environmental conditions. The model assumes that biological sites bind to metals as biotic ligands (BLs) and obtains a series of BLM parameters including conditional binding constants (K). However, developing a BLM for each metal and biology takes a lot of experimentation.

The prediction of combined toxicity of Cu-Ni for barley using an extended concentration addition model.

Environment pollution often occurs as an obvious combined effect involving two (or more) elements, and this effect changes with the concentrations of the different elements. The effects on barley root elongation were studied in hydroponic systems to investigate the toxicity of Cu-Ni combined at low doses and at a fixed concentration ratio. For low doses of Cu-Ni, the addition of Ni (<0.