Neuroprotective Indole Alkaloids from the Soil-Derived Fungus sp. XZ8.

A chemical investigation of the soil-derived fungus sp. XZ8 led to the isolation of five new indole alkaloids, trichindoles A-E (-), with diverse architectures, along with seven known analogues (-). Their structures were elucidated by extensive spectroscopic data analysis, and their absolute configurations were determined by single-crystal X-ray diffraction and modified Mosher's method.

Tracking the scaling of urban open spaces in China from 1990 to 2020.

Urban open spaces (UOS) are crucial for urban life, offering benefits across individual and societal levels. However, the understanding of the systematic dynamic of UOS scaling with city size and its potential non-linear performance remains a limited clarity area. This study bridges this gap by integrating urban scaling laws with remote sensing data from 1990 to 2020, creating a framework to analyze UOS trends in China.

Association between periodontitis and hyperlipidaemia: A systematic review and meta-analysis.

To date, it has been reported that periodontitis (PD) may be associated with hyperlipidaemia in clinical practice. However, data on this issue are inconsistent and controversial. The purpose of this meta-analysis was to identify the association between PD and hyperlipidaemia.

Osteoblast Progenitors Enhance Osteogenic Differentiation of Periodontal Ligament Stem Cells.

Background: Osteoblasts and periodontal ligament stem cells (PDLSCs) play an important role in maintaining physiologic function of periodontal tissues and participating in periodontal regeneration. Elucidation of interactions between osteoblasts and PDLSCs will aid understanding of periodontal regeneration mechanisms. This study aims to determine whether preosteoblasts can promote osteoblastic/cementoblastic differentiation of PDLSCs.

Acellular dermal matrix loading with bFGF achieves similar acceleration of bone regeneration to BMP-2 via differential effects on recruitment, proliferation and sustained osteodifferentiation of mesenchymal stem cells.

New generation of barrier membranes has been developed, which not only act as barriers but also as delivery devices to release specific growth factors. This study observed biological behaviors of bone morrow mesenchymal stem cells (BMMSCs) pretreated by bFGF or BMP-2 in vitro and evaluated differential bone regeneration process induced by bFGF and BMP-2 loaded acellular dermal matrix (ADM) membrane using critical-size rat calvarial defect model in vivo. The results showed that the proliferation capability of BMMSCs pretreated by bFGF was stronger than that by BMP-2, while there was temporally differential effect of bFGF and BMP-2 pretreatment on MSC osteogenic differentiation potentials.

Lower dosage of aspirin promotes cell growth and osteogenic differentiation in murine bone marrow stromal cells.

Background/purpose: The effect of aspirin on bone regeneration remains controversial. This study aimed to determine the effect of various concentrations of aspirin on cell viability, osteogenic differentiation, cell cycle, and apoptosis on ST2 cells to find an effective range of aspirin for bone regeneration induction.

Materials And Methods: Cell viability was measured with MTT assay after being stimulated with aspirin for 1 day, 2 days, 3 days, 5 days, and 7 days.

Effect of a weak CW trigger on optical rogue waves in the femtosecond supercontinuum generation.

We numerically study the characteristics of optical rogue waves in the femtosecond supercontinuum (SC) generation and use the CW triggering mechanism to control the SC generation. Detailed simulation results show for the first time that a weak CW trigger can manipulate the behaviors of optical rogue waves in the femtosecond SC regime. For the proposed CW triggering technique which requires only wavelength tuning and is a handy approach for the active control of SC, the resultant spectrum can be greatly broadened, and the noise properties of the SC can be significantly improved in terms of both of the coherence and intensity stability.