Publications by authors named "Xiaoping Yin"

To investigate the factors influencing the colonoscopy screening behavior of first-degree relatives of colorectal cancer patients and to provide a basis for formulating screening intervention strategies. In this study, 15 first-degree relatives of colorectal cancer patients in the Department of Medical Oncology of a tertiary hospital in Baoding City from May to July 2024 were selected as the research subjects, and face-to-face semi-structured interviews were conducted. The theme was analyzed and summarized based on the theory of planned behavior and Colaizzi's 7-step analysis method.

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Secreted protein acidic and rich in cysteine (SPARC), an essential stromal cell protein, plays a crucial role in angiogenesis and maintaining endothelial barrier function. This protein is expressed by diverse cell types, including endothelial cells, fibroblasts, and macrophages, with increased expression found in regions of tissues undergoing active remodeling, repair, and proliferation. The role of SPARC in non-neural tissues is of significant interest.

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Article Synopsis
  • Unfavorable health-related social needs (HRSNs) can worsen overall health and contribute to health disparities, particularly in cardiovascular health (CVH) among U.S. adults.
  • A study using data from the National Health and Nutrition Examination Survey analyzed the relationship between HRSNs and CVH using a scoring system, finding that a higher number of unfavorable HRSNs correlated with poorer CVH.
  • The results suggest that addressing these HRSNs through public health initiatives could help reduce health inequalities and improve cardiovascular health outcomes.
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Background And Objective: Breast cancer is the most common cancer type among women worldwide and a leading cause of female death. Accurately interpreting these complex tumors, involving small size and morphology, requires a significant amount of expertise and time. Developing a breast tumor segmentation model to assist clinicians in treatment, therefore, holds great practical significance.

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Background: The association between nonalcoholic fatty liver disease and cardiovascular disease is firmly established, yet the association between noninvasive liver fibrosis scores and cardiovascular events remains a topic of uncertainty. Our study aimed to explore the association between liver fibrosis and heart failure.

Methods And Results: The data set was from the National Health and Nutrition Examination Survey 2011 to 2018.

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Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for the management of the disease. This study compared and analyzed the proteins of total plasma exosomes (T-EXO) and placental-derived exosomes (PLAP-EXO) in pregnant women who subsequently developed GDM (12-16 weeks), GDM patients (24-28 weeks) and their corresponding controls to investigate the pathogenesis and biomarkers of GDM associated with exosomes.

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Chronic cerebral ischemia (CCI) is a common clinical syndrome that can impact various cerebrovascular diseases. Its pathological mechanism of injury involves energy imbalance, oxidative stress, inflammatory response, and many other processes. Neuronal damage occurs in a complex and multifaceted manner.

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  • The study focused on creating a deep learning (DL) model to aid in the detection and diagnosis of cerebral aneurysms, both with and without human involvement.
  • The DL model was trained on data from 3,829 patients and tested on 484 patients, comparing performance between the model, human radiologists, and a combination of both.
  • Results showed significant improvements in diagnostic speed and accuracy for radiologists when assisted by the DL model, particularly benefiting junior radiologists.
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  • The study aims to create a nomogram for early prediction of severe mycoplasma pneumoniae pneumonia (SMPP) in both pediatric and adult patients by analyzing 550 cases, classified into severe and non-severe groups.
  • Various models were developed using clinical data, imaging, and radiomics features, assessed through different statistical methods, including logistic regression and AUC metrics.
  • The integrated model showed strong predictive ability, particularly in testing cohorts, with a notable improvement when combining clinical and imaging features, demonstrating its effectiveness for identifying SMPP.
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Background: In computer-aided diagnosis (CAD) studies utilizing multireader multicase (MRMC) designs, missing data might occur when there are instances of misinterpretation or oversight by the reader or problems with measurement techniques. Improper handling of these missing data can lead to bias. However, little research has been conducted on addressing the missing data issue within the MRMC framework.

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Neurodegenerative diseases (NDDs) are increasingly prevalent with global aging, demanding effective treatments. Exosomes, which contain biological macromolecules such as RNA (including miRNAs) and proteins like α-synuclein, tau, and amyloid-beta, are gaining attention as innovative therapeutics. This comprehensive review systematically explores the potential roles of exosomes in NDDs, with a particular focus on their role in synaptic dysfunction.

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Objective: To explore the potential of the deep learning reconstruction (DLR) for ultralow dose calcium scoring CT (CSCT) with simultaneously reduced tube voltage and current.

Methods: In this prospective study, seventy-five patients (group A) undergoing routine dose CSCT (120kVp/30mAs) were followed by a low dose (120kVp/20mAs) scan and another 81 (group B) were followed by an ultralow dose (80kVp/20mAs) scan. The hybrid iterative reconstruction was used for the routine dose data while the DLR for data of reduced dose.

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Various Chemotactic Factors (FCs) play different roles in neuronal injury in vascular dementia. CXCL5 and CCL11 exacerbate neurological injury by promoting inflammatory responses. CXCL12/SDF-1 and CX3CL1 play neuroprotective roles.

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Recently, the role of high-concentration oxygen therapy in cerebral hemorrhage has been extensively discussed. This review describes the research progress in high-concentration oxygen therapy after cerebral hemorrhage. High-concentration oxygen therapy can be classified into two treatment methods: hyperbaric and normobaric high-concentration oxygen therapy.

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The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for diabetes management, are increasingly studied for their cognitive benefits. These benefits may include reduction of oxidative stress and neuroinflammation, decrease of amyloid burdens, enhancement of neuronal plasticity, and improved cerebral glucose utilization.

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  • Online psychological surveys, particularly during public health events, can efficiently gather data from college students and help design interventions, but their connection to real-life psychological symptoms hasn't been researched yet.
  • A web-based survey conducted with over 22,600 participants revealed that longer survey completion times were linked to higher levels of anxiety, depression, insomnia, and PTSD, especially between 7 p.m. and 10 p.m.
  • The findings suggest that when college students took longer to complete the survey, they were more likely to experience mental health issues, and further studies are needed to understand the causes behind these trends.
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  • The study investigates the effects of iRoot BP plus in conjunction with MTA apical barrier surgery on young permanent teeth suffering from chronic apical periodontitis, comparing it with standard MTA surgery.
  • A total of 122 patients were randomly assigned to an experimental group (iRoot BP plus) and a control group (MTA), with outcomes such as O-PAI ratings, apical transmission area, treatment frequency, and inflammatory factors assessed over 12 months.
  • Results showed the experimental group had significantly better outcomes, including lower O-PAI ratings (1.48 vs. 1.71), a smaller apical transmission area (0.51 vs. 1.09), a higher success rate (
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Background: Hepatocellular carcinoma (HCC) is often associated with the overexpression of multiple proteins and genes. For instance, patients with HCC and a high expression of the glypican-3 () gene have a poor prognosis, and noninvasive assessment of expression before surgery is helpful for clinical decision-making. Therefore, our primary aim in this study was to develop and validate multisequence magnetic resonance imaging (MRI) radiomics nomograms for predicting the expression of in individuals diagnosed with HCC.

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Stroke is a serious disease that can lead to local neurological dysfunction and cause great harm to the patient's health due to blood cerebral circulation disorder. Synaptic pruning is critical for the normal development of the human brain, which makes the synaptic circuit completer and more efficient by removing redundant synapses. The complement system is considered a key player in synaptic loss and cognitive impairment in neurodegenerative disease.

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Background: Stroke, including ischemic and hemorrhagic stroke, is a severe and prevalent acute cerebrovascular disease. The development of hypoxia following stroke can trigger a cascade of pathological events, including mitochondrial dysfunction, energy deficiency, oxidative stress, neuroinflammation, and excitotoxicity, all of which are often associated with unfavorable prognosis. Nonetheless, a noninvasive intervention, referred to as normobaric hyperoxia (NBO), is known to have neuroprotective effects against stroke.

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Background: Gestational diabetes mellitus is an endocrine and metabolic disorder that appears for the first time during pregnancy and causes varying degrees of short- and/or long-term effects on the mother and child. The etiology of the disease is currently unknown and isobaric tags for relative and absolute quantitation proteomics approach, the present study attempted to identify potential proteins in placental tissues that may be involved in the pathogenesis of GDM and adverse foetal pregnancy outcomes.

Methods: Pregnant women with GDM hospitalised were selected as the experimental group, and pregnant women with normal glucose metabolism as the control group.

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Article Synopsis
  • * Researchers evaluated the effectiveness of single-energy spectral CT imaging in enhancing the visualization of key blood vessels associated with pancreatic tumors, comparing it to mixed energy and lower energy settings.
  • * Findings showed that single-energy spectral CT provided significantly better image quality and higher CT values for blood vessels compared to mixed energy and 70 keV imaging, suggesting it could enhance pre-surgical evaluations.
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Purpose: This study aims to explore the value of clinical features, CT imaging signs, and radiomics features in differentiating between adults and children with Mycoplasma pneumonia and seeking quantitative radiomic representations of CT imaging signs.

Materials And Methods: In a retrospective analysis of 981 cases of mycoplasmal pneumonia patients from November 2021 to December 2023, 590 internal data (adults:450, children: 140) randomly divided into a training set and a validation set with an 8:2 ratio and 391 external test data (adults:121; children:270) were included. Using univariate analysis, CT imaging signs and clinical features with significant differences ( < 0.

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Background: 2D CT image-guided radiofrequency ablation (RFA) is an exciting minimally invasive treatment that can destroy liver tumors without removing them. However, CT images can only provide limited static information, and the tumor will move with the patient's respiratory movement. Therefore, how to accurately locate tumors under free conditions is an urgent problem to be solved at present.

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Background: Stroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment.

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