Patterns of spatiotemporal variations in the hydrochemistry and controlling factors of bedrock aquifers in the northern region of the Linhuan mining area.

Systematically studying the hydrochemical evolution of bedrock groundwater in mining areas during mining process is crucial for effective groundwater resource management and coal mine production. The spatiotemporal characteristics and hydrochemical evolution patterns of the Permian fractured sandstone aquifer (PA) and the Carboniferous Taiyuan Formation limestone aquifer (CTA), both of which are directly associated with coal mining in the northern Linhuan mining area, China, were investigated using multivariate statistical analyses, hydrochemical graphical methods, ion ratio analysis, and a conceptual model. 72 groundwater samples, collected before and after mining, were classified into four groups by hierarchical cluster analysis (HCA).

Photogenerated carrier dynamics of Mn2+ doped CsPbBr3 assembled with TiO2 systems: Effect of Mn doping content.

In recent years, all-inorganic perovskite materials have become an ideal choice for new thin film solar cells due to their excellent photophysical properties and have become a research hotspot. Studying the ultrafast dynamics of photo-generated carriers is of great significance for further improving the performance of such devices. In this work, we focus on the transient dynamic process of CsPbBr3/TiO2 composite systems with different Mn2+ doping contents using femtosecond transient absorption spectroscopy technology.

Pharmacoeconomic evaluation of isavuconazole, posaconazole, and voriconazole for the treatment of invasive mold diseases in hematological patients: initial therapy prior to pathogen differential diagnosis in China.

Background: Invasive mold diseases (IMD) is associated with high mortality and a substantial economic burden. For high-risk patients, fever drive or diagnostic drive therapy is usually initiated prior to the differential diagnosis of the pathogen. This study evaluated the cost-effectiveness of isavuconazole, posaconazole, vs.

Recent Advances in Statistical Theory and Applications.

Complex data pose unique challenges for data processing [...

Small object intelligent detection method based on adaptive recursive feature pyramid.

As we all know, YOLOv4 can achieve excellent detection performance in object detection and has been effectively applied in many fields. However, the inconsistency of scale features affects the prediction accuracy of the path aggregation network (PANet) in YOLOv4 for small objects, resulting in low detection accuracy. This paper presents YOLOv4, which uses an adaptive recursive path aggregation network (AR-PANet) to improve the detection accuracy of small objects.

Fuzzy C-Means Clustering: A Review of Applications in Breast Cancer Detection.

This paper reviews the potential use of fuzzy c-means clustering (FCM) and explores modifications to the distance function and centroid initialization methods to enhance image segmentation. The application of interest in the paper is the segmentation of breast tumours in mammograms. Breast cancer is the second leading cause of cancer deaths in Canadian women.

Global analysis of the COVID-19 policy activity levels and evolution patterns: A cross-sectional study.

Background And Aims: Since the beginning of the coronavirus disease 2019 (COVID-19), a large number of government policies have been implemented worldwide in response to the global spread of COVID-19. This paper aims at developing a data-driven analysis to answer the three research questions: (a) Compared to the pandemic development, are the global government COVID-19 policies sufficiently active? (b) What are the differences and characteristics in the policy activity levels at the country level? (c) What types of COVID-19 policy patterns are forming?

Methods: Using the Oxford COVID-19 Government Response Tracker data set, we present a global analysis of the COVID-19 policy activity levels and evolution patterns from January 1, 2020 to June 30, 2022, based on the differential expression-sliding window analysis (DE-SWAN) algorithm and the clustering ensemble algorithm.

Results: Within the period under study, the results indicate that (a) the global government policy responses to COVID-19 are very active, and the policy activity levels are significantly higher than those of global pandemic developments; (b) a high activity of policy is positively correlated to pandemic prevention at the country level; and (c) a high human development index (HDI) score is negatively correlated to the country policy activity level.

Analysis of air pollution in Fenwei Plain in China based on functional spatial autoregressive combined model.

The Fenwei Plain is listed as one of the most serious air pollution regions in China, along with Beijing-Tianjin-Hebei and Yangtze River Delta regions. This paper proposed a functional data analysis method to study the environmental pollution problem in the Fenwei Plain of China. Functional spatial autoregressive combined (FSAC) model with spatial autocorrelation of both the response variable and error term is developed.

A multi-objective optimization framework with rule-based initialization for multi-stage missile target allocation.

This paper investigates a novel multi-objective optimization framework for the multi-stage missile target allocation (M-MTA) problem, which also widely exists in other real-world complex systems. Specifically, a constrained model of M-MTA is built with the trade-off between minimizing the survivability of targets and minimizing the cost consumption of missiles. Moreover, a multi-objective optimization algorithm (NSGA-MTA) is proposed for M-MTA, where the hybrid encoding mechanism establishes the expression of the model and algorithm.

Effect of Fiber Fraction on Ballistic Impact Behavior of 3D Woven Composites.

This paper studies the ballistic impact performance of 3D woven composites (3DWCs) with hexagonal binding patterns. Para-aramid/polyurethane (PU) 3DWCs with three kinds of fiber volume fraction (V) were prepared by compression resin transfer molding (CRTM). The effect of V on the ballistic impact behavior of the 3DWCs was analyzed by characterizing the ballistic limit velocity (V50), the specific energy absorption (SEA), the energy absorption per thickness (E), the damage morphology and the damage area.

Two-Sample Tests Based on Data Depth.

In this paper, we focus on the homogeneity test that evaluates whether two multivariate samples come from the same distribution. This problem arises naturally in various applications, and there are many methods available in the literature. Based on data depth, several tests have been proposed for this problem but they may not be very powerful.

Cost-effectiveness of ceftazidime/avibactam plus metronidazole versus meropenem as first-line empiric therapy for the treatment of complicated intra-abdominal infections: A study based on the in-vitro surveillance data in China.

Background: With the increase in drug resistance rates of pathogens isolated from complicated intra-abdominal infections (cIAIs), ceftazidime/avibactam (CAZ-AVI) is increasingly used clinically. However, given the high drug cost and the fact that not yet covered by the health insurance payment, this study evaluated the cost-effectiveness of CAZ-AVI plus metronidazole versus meropenem as a first-line empiric treatment for cIAIs from the perspective of the Chinese healthcare system.

Methods: A decision analytic model with a one-year time horizon was constructed to assess the cost-effectiveness based on the entire disease course.

Study on Curing Deformation of Composite Thin Shells Prepared by M-CRTM with Adjustable Injection Gap.

A composite thin shell with a high fiber volume fraction prepared by resin transfer molding (RTM) may have void defects, which create deformations in the final curing and lead to the final product being unable to meet the actual assembly requirements. Taking a helmet shell as an example, a multi-directional compression RTM (M-CRTM) method with an adjustable injection gap is proposed according to the shape of the thin shell. This method can increase the injection gap to reduce the fiber volume fraction during the injection process, making it easier for the resin to penetrate the reinforcement and for air bubbles to exit the mold.

A New Class of Weighted CUSUM Statistics.

A change point is a location or time at which observations or data obey two different models: before and after. In real problems, we may know some prior information about the location of the change point, say at the right or left tail of the sequence. How does one incorporate the prior information into the current cumulative sum (CUSUM) statistics? We propose a new class of weighted CUSUM statistics with three different types of quadratic weights accounting for different prior positions of the change points.

Pressure-Induced Tunable Charge Carrier Dynamics in Mn-Doped CsPbBr Perovskite.

All-inorganic perovskite materials (CsPbX) have attracted increasing attention due to their excellent photoelectric properties and stable physical and chemical properties. The dynamics of charge carriers affect the photoelectric conversion efficiencies of perovskite materials. Regulating carrier dynamics by changing pressure is interesting with respect to revealing the key microphysical processes involved.

Cognitive processing features of elementary school children with mathematical anxiety: Attentional control theory-based explanation.

A growing body of research suggests that mathematical anxiety (MA) seriously affects an individual's math achievement. However, few studies have focused on the cognitive mechanisms of MA in elementary school children. Based on attention control theory (ACT), this research aimed to explore the cognitive mechanism of MA in elementary school children using two studies.

MCMCINLA Estimation of Missing Data and Its Application to Public Health Development in China in the Post-Epidemic Era.

Medical data are often missing during epidemiological surveys and clinical trials. In this paper, we propose the MCMCINLA estimation method to account for missing data. We introduce a new latent class into the spatial lag model (SLM) and use a conditional autoregressive specification (CAR) spatial model-based approach to impute missing values, making the model fit into the integrated nested Laplace approximation (INLA) framework.

Alpha/Theta Ratio Neurofeedback Training for Attention Enhancement in Normal Developing Children: A Brief Report.

Attention plays an important role in children's development and learning, and neurofeedback training (NFT) has been proposed as a promising method to improve attention, mainly in population with attention problems such as attention deficit hyperactivity disorder. However, whether this approach has a positive effect on attention in normal developing children has been rarely investigated. This pilot study conducted ten sessions of alpha/theta ratio (ATR) NFT on eight primary students in school environment, with two to three sessions per week.

A retrospective observational study of the treatment with polymyxin B for liver transplantation recipients infected by multidrug-resistant gram-negative bacteria.

What Is Known And Objective: Only a few studies about polymyxin B (PMB) against multidrug-resistant gram-negative bacteria (MDR GNB) infection were conducted in liver transplantation recipients (LTRs). The purpose of this study was to investigate the efficacy and safety of PMB in the treatment of MDR-GNB in liver transplant recipients and to determine the risk factors affecting clinical cure and 30-day all-cause mortality.

Methods: Data of LTRs receiving PMB from January 2016 to February 2020 were collected.

A case report of drug-induced liver injury after tigecycline administration: histopathological evidence and a probable causality grading as assessed by the updated RUCAM diagnostic scale.

Background: There have been no reports of tigecycline-associated drug-related liver injury (DILI) identified by histopathological assistance and causal assessment method. We reported the histopathological manifestations for the first time and described tigecycline-associated liver injury's pattern, severity, duration, and outcome.

Case Presentation: A 68-year-old male with post-liver transplantation was given high-dose tigecycline intravenously (loading dose 200 mg, followed by 100 mg every 12 h) combined with polymyxin B (50,000 units by aerosol inhalation every 12 h) for hospital-acquired pneumonia caused by carbapenem-resistant Klebsiella pneumoniae.

Degradation of Methyl Orange by ozone microbubble process with packing in the bubble column reactor.

The performance of the ozone microbubble(MB) process for the degradation of Methyl Orange (MO) in a bubble column reactor with added packing was investigated. The highest decolorization efficiency of 96.04% was achieved by the ozone MB process with packing, which was 10.

Real-World Data of Tigecycline-Associated Drug-Induced Liver Injury Among Patients in China: A 3-year Retrospective Study as Assessed by the Updated RUCAM.

Tigecycline, a glycylcycline antibiotic, is increasingly used clinically for the treatment of severe infections caused by multidrug-resistant bacteria, but it is also associated with hepatotoxicity. However, the incidence and risk factors of tigecycline-associated drug-induced liver injury (DILI) are unclear. We conducted this study to investigate the incidence, characteristics and risk factors of tigecycline-associated DILI in the real-world clinic setting.

Comparative pharmacokinetics of baicalin and geniposide in juvenile and adult rats after oral administration of Qingkailing Granules.

Objective: To explore the effect of age on Qingkailing Granules disposition by comparing the pharmacokinetics of geniposide and baicalin in juvenile and adult rats.

Methods: A simple and rapid LC-MS/MS method was developed and validated to simultaneously determine geniposide and baicalin in rat plasma after a simple protein precipitation. The analytes were separated on an Agilent ZORBAX Extend-C column.

Enzymatic synthesis of 2-hydroxy-4-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from .

2-Hydroxy-4-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus MT-12, malonyl-CoA synthase (AtMatB) from , and a type III polyketide synthase (HsPKS3) from Chinese club moss . The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms.