Constraints of weathering intensity in different climate zones on coal accumulation environment.

There are currently multiple hypotheses regarding coal accumulation models, each with certain limitations in applicability. This article investigates the relationship between modern sedimentation, soil and climate to analyze the distribution of coal across different geological periods, aiming to explain the coal accumulation environment within a unified theoretical framework. The research concludes that the intensity of weathering in various climate zones is a determining factor influencing coal formation, which also affects the distribution of two other climate-sensitive sedimentary deposits - evaporite and bauxite.

A new vetivane-type sesquiterpenoid with a tricyclic 7/5/5 scaffold from the endophytic fungus 2021CDF-3.

Natural sesquiterpenoids possess a variety of skeleton types with intriguing biomedical activities. In this study, a comprehensive chemical study of the endophytic fungus 2021CDF-3 yielded a new sesquiterpenoid, namely penicivetivane A (). The chemical structure for was thoroughly ascertained by using HRESIMS and NMR spectroscopic analyses, while the stereochemistry of was further verified by X-ray diffraction analyses.

Knockdown of FOXO6 Inhibits Glycolysis and Reduces Cell Resistance to Paclitaxel in HCC Cells via PI3K/Akt Signaling Pathway.

Purpose: Previous studies have reported that FOXO6 is highly expressed in hepatocellular carcinoma (HCC) tissues and is associated with the prognosis of HCC patients. However, little research has been carried out to explore the role of FOXO6 in glycolysis of HCC cells and paclitaxel resistance. Today, along with the increasing incidence and mortality of HCC, chemotherapy resistance of HCC also poses a serious challenge.