Microsatellite density landscapes illustrate short tandem repeats aggregation in the complete reference human genome.

Background: Microsatellites are increasingly realized to have biological significance in human genome and health in past decades, the assembled complete reference sequence of human genome T2T-CHM13 brought great help for a comprehensive study of short tandem repeats in the human genome.

Results: Microsatellites density landscapes of all 24 chromosomes were built here for the first complete reference sequence of human genome T2T-CHM13. These landscapes showed that short tandem repeats (STRs) are prone to aggregate characteristically to form a large number of STRs density peaks.

The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.

To explore the relationship between serum folic acid (FA) or Vitamin B12 (VB12) and elevated BP in children and adolescents. Both a nested case control and a cohort study were designed to explore the relationship between serum folic acid (FA) or Vitamin B12 (VB12) and elevated blood pressure (BP). All the included participants were from primary school.

Novel multi-mode anti-counterfeiting encryption material of CaAlO:Eu, Er with multi-color down-conversion luminescence, up-conversion luminescence, dynamic luminescence, and photochromism.

Multi-mode dynamic anti-counterfeiting materials can provide complex anti-counterfeiting performance and ensure the anti-counterfeiting strategy becomes more secure. Herein, a new type of multi-mode anti-counterfeiting encryption material of CaAlO:Eu, Er with different Er doping concentration was developed by sol-gel method. Interestingly, the CaAlO:Eu, Er phosphor and its composite have multi-mode anti-counterfeiting characteristics of multi-color down-conversion luminescence, up-conversion luminescence, dynamic luminescence, and photochromism.

Effects of different types of exercise intensity on improving health-related physical fitness in children and adolescents: a systematic review.

A substantial body of empirical evidence reveals that physical activity is associated with a wide range of positive physical and mental health outcomes. However, an absence of comprehensive syntheses is observed concerning the varying effects of different exercise intensities on the improvement of physical health among children and adolescents. The aim of this review is to systematically investigate the effects of different exercise intensities on the physical fitness of children and adolescents, to analyses the optimal exercise intensities for improving physical fitness, and to provide a relevant theoretical basis for optimizing school physical education curricula.

Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice.

Up to 25% of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit postacute cognitive sequelae. Although millions of cases of coronavirus disease 2019 (COVID-19)-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. Interleukin-1 (IL-1), a key component of innate immune defense against SARS-CoV-2 infection, is elevated in the hippocampi of individuals with COVID-19.

A Qualitative Study of the Care Experience of Mothers of Asthmatic Children from Low-Income Families.

Objectives: This study aimed to explore the experiences and caregiving perspectives of mothers from low-income families who have children with asthma,and to establish a foundation for the development of tailored nursing strategies specifically designed for families facing similar circumstances.

Method: A descriptive qualitative research method was employed. Fifteen mothers of asthmatic children from low-income families receiving treatment at the Respiratory Centre of Chongqing Children's Hospital were purposefully sampled from June to December 2021.

Maltodextrin as a Commercial-Grade Electrolyte Additive Against Dendrite Formation and Side Reactions for Aqueous Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) directly using zinc metal anodes are promising candidates for grid-scale energy storage systems due to their intrinsic high theoretical capacity, high safety, and environmental friendliness. However, the uncontrolled dendrite growth and water-triggered side reactions seriously plague its practical application. Herein, a cost-effective and green additive, maltodextrin (MD) is presented, to simultaneously guide the smooth Zn deposition and inhibit the occurrence of water-related side reactions.

Effect of physical activity on anxiety, depression and obesity index in children and adolescents with obesity: A meta-analysis.

For Full-length Articles: This study systematically identified the effects of physical activity (PA) on depression, anxiety and weight-related outcomes among children and adolescents with overweight/obesity. EMBASE, The Cochrane Library, Web of Science, and PubMed were searched from January 1, 2000 to August 1, 2022 for peer-reviewed papers. Meta-analyses were conducted to ascertain the effect of physical activity on symptoms of anxiety, depression and weight-related outcomes in overweight/obese children and adolescents.

Vaccination prevents IL-1β-mediated cognitive deficits after COVID-19.

Up to 25% of SARS-CoV-2 patients exhibit post-acute cognitive sequelae. Although millions of cases of COVID-19-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. Interleukin-1, a key component of innate immune defense against SARS-CoV-2 infection, is elevated in the hippocampi of COVID-19 patients.

Fluorogen-Functionalized Mesoporous Silica Hybrid Sensing Materials: Applications in Cu Detection.

Since Cu ions play a pivotal role in both ecosystems and human health, the development of a rapid and sensitive method for Cu detection holds significant importance. Fluorescent mesoporous silica materials (FMSMs) have garnered considerable attention in the realm of chemical sensing, biosensing, and bioimaging due to their distinctive structure and easily functionalized surfaces. As a result, numerous Cu sensors based on FMSMs have been devised and extensively applied in environmental and biological Cu detection over the past few decades.

Exercise intervention and improvement of negative emotions in children: a meta-analysis.

Background: Anxiety, depression, and stress are the most common mental health problems in childhood. Exercise interventions in childhood help to promote mental health.

Objective: To investigate the relationship between exercise interventions and improvement of negative emotions such as anxiety, depression, and stress in children (5-12 years).

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons.

Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved several mechanisms to inhibit type I interferon (IFN) signaling within infected cells, whether this inhibits virologic control during neuroinvasion along OSN has not been studied. Here, we utilized an established murine model of intranasal infection with VEEV to assess the cellular targets and IFN signaling responses after VEEV exposure.

An Evaluation Index System for Core Competencies of Specialist Nurses in Pediatric Emergency Care.

We aimed to construct an evaluation index system for the core competencies of specialist nurses in pediatric emergency care using the Delphi method. We preliminarily defined 3 levels of evaluation indices for the core competencies in this nursing specialty through literature review and qualitative analysis. We conducted 2 rounds of expert consultation (using the Delphi method) to screen, revise, and finalize the indices.

A Portable Pull-Out Soil Profile Moisture Sensor Based on High-Frequency Capacitance.

Soil profile moisture is a crucial parameter of agricultural irrigation. To meet the demand of soil profile moisture, simple fast-sensing, and low-cost in situ detection, a portable pull-out soil profile moisture sensor was designed based on the principle of high-frequency capacitance. The sensor consists of a moisture-sensing probe and a data processing unit.

NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection.

Genital herpes is characterized by recurrent episodes of epithelial blistering. The mechanisms causing this pathology are ill defined. Using a mouse model of vaginal herpes simplex virus 2 (HSV-2) infection, we show that interleukin-18 (IL-18) acts upon natural killer (NK) cells to promote accumulation of the serine protease granzyme B in the vagina, coinciding with vaginal epithelial ulceration.

A total-internal-reflection-based Fabry-Pérot resonator for ultra-sensitive wideband ultrasound and photoacoustic applications.

In photoacoustic and ultrasound imaging, optical transducers offer a unique potential to provide higher responsivity, wider bandwidths, and greatly reduced electrical and acoustic impedance mismatch when compared with piezoelectric transducers. In this paper, we propose a total-internal-reflection-based Fabry-Pérot resonator composed of a 12-nm-thick gold layer and a dielectric resonant cavity. The resonator uses the same Kretschmann configuration as surface plasmon resonators (SPR).

Reduced volume of diabetic pancreatic islets in rodents detected by synchrotron X-ray phase-contrast microtomography and deep learning network.

The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets in diabetic rodents by the synchrotron radiation X-ray phase-contrast microtomography (SRμCT) at the ID17 station of the European Synchrotron Radiation Facility. The large-size images (3.

Na-Activation Engineering in the NaV(PO) Cathode with Boosting Kinetics for Fast-Charging Na-Ion Batteries.

Na superionic conductor-structured phosphates have attracted wide interest due to their high working voltage and fast Na migration facilitated by the robust 3D open framework. However, they usually suffer from low-rate capability and inferior cycling stability due to the low intrinsic electronic conductivity and limited activated Na ions. Herein, a doping protocol with Na in the V site is developed to activate extra electrochemical Na ions and expand the migration path of Na, leading to the improvement of the electronic conductivity and diffusion kinetics.

COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis.

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with acute and postacute cognitive and neuropsychiatric symptoms including impaired memory, concentration, attention, sleep and affect. Mechanisms underlying these brain symptoms remain understudied. Here we report that SARS-CoV-2-infected hamsters exhibit a lack of viral neuroinvasion despite aberrant blood-brain barrier permeability.

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.

Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (K) channels is a key event in this process. However, K channel closure alone is not sufficient to induce β-cell electrical activity; activation of a depolarizing membrane current is also required.

Design of a Phenotypic Sensor About Protein and Moisture in Wheat Grain.

A near-infrared (NIR) spectrometer can perceive the change in characteristics of the grain reflectance spectrum quickly and nondestructively, which can be used to determine grain quality information. The full-band spectral information of samples of multiple physical states can be measured using existing instruments, yet it is difficult for the full-band instrument to be widely used in grain quality detection due to its high price, large size, non-portability, and inability to directly output the grain quality information. Because of the above problems, a phenotypic sensor about grain quality was developed for wheat, and four wavelengths were chosen.

Quality appraisal of clinical practice guidelines on physical restraints in ICU: a systematic review.

Background: Physical restraint has been regarded as a protective measure in the intensive care unit (ICU) in order to avoid unexpected events. But a great number of researches have proven that physical restraints can cause bad influences on patients' mental health, such as language delays of children, sense of uncertainty, loss of trust, etc. However, it is unclear whether there are currently high-quality clinical practice guidelines (CPGs) to guide clinical practice in physical restraints.

Multi-Modal Deep Learning for Weeds Detection in Wheat Field Based on RGB-D Images.

Single-modal images carry limited information for features representation, and RGB images fail to detect grass weeds in wheat fields because of their similarity to wheat in shape. We propose a framework based on multi-modal information fusion for accurate detection of weeds in wheat fields in a natural environment, overcoming the limitation of single modality in weeds detection. Firstly, we recode the single-channel depth image into a new three-channel image like the structure of RGB image, which is suitable for feature extraction of convolutional neural network (CNN).