Lifespan trajectories of the morphology and tractography of the corpus callosum: A 5.0 T MRI study.

The corpus callosum (CC) is the largest white matter fiber bundle connecting the two hemispheres, facilitating interhemispheric integration and hemispheric specialization. Neuroimaging studies have identified the CC as a marker for aging and various neuropsychiatric disorders. However, studies focusing on high-resolution imaging and detailed lifespan characterizations of CC morphology and connectivity are still limited, highlighting the need for further investigation.

Comparison of single shot and multishot diffusion-weighted imaging in 5-T magnetic resonance imaging for brain disease diagnosis.

Background: Diffusion-weighted imaging (DWI) with single-shot echo-planar imaging (ssEPI) is a valuable tool for detecting acute brain lesions but does suffer from image distortions. Multishot echo-planar imaging (msEPI) is a technique for reducing such distortions. This study aimed to compare the image quality and diagnostic efficacy of ssEPI- and msEPI-DWI at 5.

Endovascular treatment of ruptured basilar artery trunk aneurysms: complications and long-term outcomes.

Object: Treatment of ruptured basilar artery trunk (BAT) aneurysms is challenging, and is associated with high complication and mortality rates. Herein, we analyzed the complications, long-term outcomes, and outcome predictors of endovascular treatment for ruptured BAT aneurysms.

Methods: Between January 2011 and July 2023, 36 patients with 36 ruptured BAT aneurysms underwent endovascular treatment at our institution.

Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results.

Purpose: Glutamate chemical exchange saturation transfer (GluCEST) is a non-invasive CEST imaging technique for detecting glutamate levels in tissues. We aimed to investigate the reproducibility of the 5T GluCEST technique in healthy volunteers and preliminarily explore its potential clinical application in patients with brain tumors.

Methods: Ten volunteers (4 males, mean age 29 years) underwent three 5T GluCEST imaging scans.

Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial.

Background: Hyperlipidemia is a common feature of chronic diseases. The aim of this work was designed to assess the role of probiotics (Lactobacillus casei Zhang, Bifidobactetium animalis subsp. lactis V9, and Lactobacillus plantarum P-8) in the treatment of hyperlipidemia.

ML241 Antagonizes ERK 1/2 Activation and Inhibits Rotavirus Proliferation.

Rotavirus (RV) is the main pathogen that causes severe diarrhea in infants and children under 5 years of age. No specific antiviral therapies or licensed anti-rotavirus drugs are available. It is crucial to develop effective and low-toxicity anti-rotavirus small-molecule drugs that act on novel host targets.

The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study.

Purpose: This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T.

Quantifying H&E staining results, grading and predicting IDH mutation status of gliomas using hybrid multi-dimensional MRI.

Objective: To assess the performance of hybrid multi-dimensional magnetic resonance imaging (HM-MRI) in quantifying hematoxylin and eosin (H&E) staining results, grading and predicting isocitrate dehydrogenase (IDH) mutation status of gliomas.

Materials And Methods: Included were 71 glioma patients (mean age, 50.17 ± 13.

Improved Detection of Target Metabolites in Brain Tumors with Intermediate TE, High SNR, and High Bandwidth Spin-Echo Sequence at 5T.

Background And Purpose: Due to high chemical shift displacement, challenges emerge at ultra-high fields when measuring metabolites using H-MRS. Our goal was to investigate how well the high SNR and high bandwidth spin-echo (HISE) technique perform at 5T for detecting target metabolites in brain tumors.

Materials And Methods: Twenty-six subjects suspected of having brain tumors were enrolled.

Study on the electrodeposition of uranium in chloride molten salt.

This study focuses on the recovery of UO from oxide spent fuel using electrodeposition. UO was used as the initial material and dissolved in NaCl-2CsCl using NHCl at high temperatures by means of chlorination reaction. The electrolysis process was conducted using a three-electrode system to investigate the effects of cathode material and diameter, electrolysis temperature, electrolysis time, electrolysis voltage, and uranium concentration in the molten salt on the electrolysis reaction.

Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice.

Rotaviruses (RVs) are a major cause of diarrhea in young children worldwide. The currently available and licensed vaccines contain live attenuated RVs. Optimization of live attenuated RV vaccines or developing non-replicating RV (e.

Disturbed meningeal lymphatic function associated with malignancy and progression in patients with intracranial malignant tumors.

Background: Meningeal lymphatic vessels (mLVs) have proven to bear a relationship with tumor immunity and therapeutic efficacy of intracranial malignant tumors in pre-clinical animal studies. We aimed to explore the association between mLV function and intracranial malignant tumors in clinical participants.

Methods: The participants were allocated to a control group or a group of patients with intracranial tumors.

Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways.

Over the past few decades, osteoarthritis (OA) has been a major health problem worldwide. It is urgent to develop new, effective, and safe drugs to treat OA. There are many pentacyclic triterpenoids in nature that are safe and have health benefits.

Mesenchymal stromal cell biotherapy for Parkinson's disease premotor symptoms.

Parkinson's disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as anxiety, cognitive dysfunction, depression, hyposmia, and sleep disorders. NMS is presented in at least one-fifth of the patients with PD. With the histological information being investigated, stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD conditions.

Characterizing cerebrospinal fluid mobility using heavily T2-weighted 3D fast spin echo (FSE) imaging with improved multi-directional diffusion-sensitized driven-equilibrium (iMDDSDE) preparation.

Cerebrospinal fluid (CSF) flow patterns and their relationship with arterial pulsation can depict the function of glymphatic system (GS). We propose an improved multi-directional diffusion-sensitized driven-equilibrium (iMDDSDE) prepared heavily T2-weighted 3D FSE (iMDDSDE-HT2) magnetic resonance imaging (MRI) method to noninvasively assess the mobility (MO) of CSF distributed in the ventricles and perivascular spaces (PVS). This method could obtain 3D high resolution (1 mm isotropic) imaging of CSF MO with full brain coverage within five min and distinguish the CSF MO across different pulse phases using a peripheral pulse unit (PPU).

Stability and repeatability of diffusion-weighted imaging (DWI) of normal pancreas on 5.0 Tesla magnetic resonance imaging (MRI).

To explore the stability and repeatability of diffusion-weighted imaging (DWI) of normal pancreas with different field of views (FOV) on 5.0 T magnetic resonance imaging (MRI) system. Twenty healthy subjects underwent two sessions of large FOV (lFOV) and reduced FOV (rFOV) DWI sequence scanning.

Functional abnormalities of the cerebellum in vascular mild cognitive impairment.

Objectives: The alterations in cerebellar activity that occur in vascular mild cognitive impairment remain largely unexplored. This study aimed to investigate potential associations between abnormal cerebellar functional connectivity (FC) and changes in cognitive function by examining intracerebellar and cerebellar-cerebral FC.

Methods: MRI data were collected from seventy-two patients with vascular mild cognitive impairment (VMCI), comprising 38 patients with small vessel mild cognitive impairment (SVMCI) and 34 with poststroke mild cognitive impairment (PSMCI), and from 43 demographically matched healthy controls (HCs).

Geochemical fractionation, bioaccessibility and ecological risk of metallic elements in the weathering profiles of typical skarn-type copper tailings from Tongling, China.

Nonferrous metal tailings have long posed a significant threat to the surrounding environment and population. Previous studies have primarily focused on heavy metal pollution in the vicinity of sulfide tailings, while little attention was given to metal mobility and bioavailability within skarn-type tailings profile during weathering. Therefore, this study aimed to investigate the fractionation, bioaccessibility, and ecological risk associated with metallic elements (MEs, including Pb, Cd, Cr, Zn, and Cu) in two representative weathering copper-tailings profiles of Tongling mine (China).

The Aging Behavior and Life Prediction of CFRP Rods under a Hygrothermal Environment.

Carbon fiber-reinforced polymer (CFRP) composites have been widely used in civil engineering structures due to their excellent mechanical and durability properties. The harsh service environment of civil engineering leads to significant degradation of the thermal and mechanical performances of CFRP, which then reduces its service reliability, service safety, and life. Research on the durability of CFRP is urgently needed to understand the long-term performance degradation mechanism.

A unified hybrid transformer for joint MRI sequences super-resolution and missing data imputation.

High-resolution multi-modal magnetic resonance imaging (MRI) is crucial in clinical practice for accurate diagnosis and treatment. However, challenges such as budget constraints, potential contrast agent deposition, and image corruption often limit the acquisition of multiple sequences from a single patient. Therefore, the development of novel methods to reconstruct under-sampled images and synthesize missing sequences is crucial for clinical and research applications.

The Long-Term Interfacial Evolution and Prediction of Carbon- and Glass-Fiber-Reinforced Epoxy Hybrid Rods under a Hygrothermal Environment.

In order to promote the engineering applications of carbon- and glass-fiber-reinforced epoxy hybrid rods, it is necessary to fully understand its long-term hygrothermal durability. In the present study, the water absorption behaviors of a hybrid rod in a water immersion environment are studied experimentally, the degradation rules of the mechanical properties are obtained, and establishing a life prediction model is attempted. The water absorption of the hybrid rod confirms to the classical Fick's diffusion model, and the water absorption concentration is determined by radial position, immersion temperature, and immersion time.

More than one quarter of Africa's tree cover is found outside areas previously classified as forest.

The consistent monitoring of trees both inside and outside of forests is key to sustainable land management. Current monitoring systems either ignore trees outside forests or are too expensive to be applied consistently across countries on a repeated basis. Here we use the PlanetScope nanosatellite constellation, which delivers global very high-resolution daily imagery, to map both forest and non-forest tree cover for continental Africa using images from a single year.

The disruption of white matter integrity of systemic striatal circuits in alcohol-dependent males with physiological cue reactivity.

Alcohol dependence (AD) is a chronic and relapsing disorder. Conditioned cues associated with the rewarding properties of drugs could trigger motivational/physiological reactions and render subjects vulnerable to relapse. Striatal circuit dysfunction has been implicated in alcohol addiction behaviours.