In silico modeling of targeted protein degradation.

Targeted protein degradation (TPD) techniques, particularly proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD), have offered novel strategies in drug discovery. With rapid advancement of computer-aided drug design (CADD) and artificial intelligence-driven drug discovery (AIDD) in the biomedical field, a major focus has become how to effectively integrate these technologies into the TPD drug discovery pipeline to accelerate development, shorten timelines, and reduce costs. Currently, the main research directions for applying CADD and AIDD in TPD include: 1) ternary complex modeling; 2) linker generation; 3) strategies to predict degrader targets, activities and ADME/T properties; 4) In silico degrader design and discovery.

Multi-dimensional multiplexed, tri-comb and quad-comb generation from a bidirectional mode-locked fiber laser.

Tri-comb and multi-comb techniques could enable many advanced measurement applications beyond the reach of traditional dual-comb schemes. However, the sophisticated and bulky control systems of the conventional schemes based on three comb lasers render them impractical for many potential applications. Like their dual-comb counterparts, tri-comb and multi-comb lasers are being investigated as attractive alternatives.

Oleaginous Microalgae from Dairy Farm Wastewater for Biodiesel Production: Isolation, Characterization and Mass Cultivation.

Producing biodiesel from microalgae grown in wastewater is environment-friendly and cost-effective. The present study investigated the algae found in wastewater of a local dairy farm for their potential as biodiesel feedstocks. Thirteen native algal strains were isolated.

[Emodin ameliorates the peritoneal dialysis-related peritoneal fibrosis via inhibiting the activation of Notch pathway].

Long term peritoneal dialysis (PD) is often associated with peritoneal fibrosis. The aim of this study was to explore the effect of emodin on PD-related peritoneal fibrosis and its related cellular and molecular mechanism. PD-related peritoneal fibrosis rats and cultured rat peritoneal mesothelial cells were recruited in the experiment.

Measurement of the extinction coefficients of magnetic fluids.

A novel spectral transmittance approach for measuring the extinction coefficient of magnetic fluids is proposed. The measuring principle and accuracy of the approach are analysed. Experiments are conducted to measure the extinction coefficient of magnetic fluids with different particle volume fractions.