Synopsis of recent research by authors named "Xiaoning Bi"
- Xiaoning Bi's recent research primarily focuses on the neurobiological mechanisms underlying neurodevelopmental disorders such as Angelman syndrome and the role of calpain-1 and calpain-2 in synaptic plasticity and neuroprotection.
- Findings indicate that 5-HT7R stimulation can rescue synaptic plasticity alterations in Angelman syndrome model mice, while inhibiting calpain-2 has protective effects in traumatic brain injury models, highlighting the therapeutic potential of targeting these pathways.
- Bi also emphasizes the complexity of calpain functions, showing that calpain-1 and calpain-2 perform opposing roles in learning and memory processes, and their dysregulation is linked to conditions like Angelman syndrome and traumatic brain injury.
