Publications by authors named "Xiaonan Ma"

Intramolecular singlet fission (SF) in multichromophore systems is of high interest for photovoltaic application. As an attractive candidate for SF-based devices, enabling efficient SF in covalent oligomers of perylene diimide (PDI) still remains challenging. In this work, inter-PDI SF with τ = ∼150 ps and ∼150% triplet yield in a covalent tetramer COTh-FPDI was facilitated by employing a saddle-shaped cyclooctatetrathiophene (COTh) core and fused linking with PDIs.

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Objective: The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and psoriasis remains unclear. This study aims to analyze the association between ACE gene I/D polymorphism and the risk of psoriasis vulgaris in the Chinese Han population and to examine the correlation between ACE gene I/D polymorphism and psoriasis with comorbid hypertension and diabetes.

Methods: A total of 358 patients with psoriasis vulgaris and 347 age- and sex-matched healthy volunteers from the Chinese Han population were selected.

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The construction of three-dimensional nanocarbon structures with well-defined molecular dynamics is a challenging yet rewarding task in material science and supramolecular chemistry. Herein, we report the synthesis of two highly defective, nitrogen-doped molecular cylinders, namely MC1 and MC2, with a length of 1.4 nm and 2.

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Delayed fluorescence (DF) is a unique emitting phenomenon of great interest for important applications in organic optoelectronics. In general, DF requires well-separated frontier orbitals, inherently corresponding to charge transfer (CT)-type emitters. However, facilitating intrinsic DF for local excited (LE)-type conjugated emitters remains very challenging.

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Article Synopsis
  • Postoperative ileus (POI) is a common complication after abdominal surgery that increases hospital stays and costs, yet the link between grip strength and POI in minimally invasive surgery (MIS) has been under-researched.
  • A study analyzing 393 patients who underwent abdominal MIS found that higher grip strength was significantly associated with a lower risk of developing POI, particularly in males and older adults.
  • The findings suggest that assessing grip strength pre-surgery could help identify patients at higher risk for POI, allowing for better management and potentially improved recovery outcomes.
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2,5-Bis(phenylethynyl) rhodacyclopentadienes (RCPDs), as a type of Rh(iii) complex, exhibit unusually intense fluorescence and slow intersystem crossing (ISC) due to weak metal-ligand interactions. However, details on their ultrafast photophysics and ISC dynamics are limited. In this work, electronic relaxation upon photoexcitation of two substituted RCPDs with two -COMe (A-RC-A) or -NMe/-COMe (D-RC-A) end groups are comprehensively investigated using femtosecond transient absorption spectroscopy and theoretical analysis.

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Root hair growth has been studied to understand the principles underlying the regulation of directional growth. Arabidopsis (Arabidopsis thaliana) [Ca2+]cyt-ASSOCIATED PROTEIN KINASE 1 (CAP1) maintains normal vesicle trafficking and cytoskeleton arrangement during root hair growth in response to ammonium signaling. In the current study, we identified CAP1 SUPPRESSOR 1 (CAPS1) as a genetic suppressor of the cap1-1 mutation.

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Purpose: To explore the efficacy of iRoot BP plus in the treatment of adult carious pulp exposure and its impact on pulp blood flow.

Methods: A total of 126 cases of 156 permanent teeth from adult patients with carious pulp exposure who were treated from January 2020 to January 2022 were selected, the patients were divided into experimental group(63 cases with 79 permanent teeth) and control group(63 cases with 77 permanent teeth) by the envelope method. The experimental group was treated with iRoot BP plus, while the control group was treated with mineral trioxide polymer.

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The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the underlying mechanisms remain elusive. Gut microbiota and metabolites have been suggested to mediate the metabolic changes caused by KD consumption, although the particular gut microbes or metabolites involved are unclear. Here, we show that KD consumption enhances serum levels of taurodeoxycholic acid (TDCA) and tauroursodeoxycholic acid (TUDCA) in mice to decrease body weight and fasting glucose levels.

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Organic semiconductors (OSCs) are one of the most promising candidates for flexible, wearable and large-area electronics. However, the development of n-type OSCs has been severely held back due to the poor stability of their most candidates, that is, the intrinsically high reactivity of negatively charged polarons to oxygen and water. Here we demonstrate a general strategy based on vitamin C to stabilize n-type OSCs, remarkably improving the performance and stability of their device, for example, organic field-effect transistors.

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Article Synopsis
  • The study investigates the safety and efficacy of anti-PD-1 monoclonal antibodies (mAbs), comparing traditional IgG4 frameworks with a potentially safer Fc-null IgG1 alternative to reduce adverse effects from Fc-Fc interactions.
  • Researchers conducted various binding tests and immune response assessments using different types of antibodies on tumor cells, using both in vitro experiments and mouse models.
  • Results indicated that IgG4, including the anti-PD-1 mAb nivolumab, negatively impacted immune responses like cell-mediated cytotoxicity, raising concerns about their effectiveness in cancer treatment.
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We examined the joint association of physical activity (PA) and socio-economic status (SES) on all-causes and cardiovascular disease (CVD) mortality in 6945 elderly Koreans (mean age: 71.6 years, 41.8% male) using data from the Korean National Health and Nutrition Examination Survey (2007-2013) and death data from Statistics Korea (2019).

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The profiles of muscle and joint pain throughout the menopausal transition and the factors associated with these symptoms have not been determined. A total of 609 participants from a longitudinal cohort study conducted in an urban Chinese community were enrolled in this study. We assessed the prevalence of musculoskeletal symptoms at different menopausal stages and explored the factors associated with these symptoms.

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The application of thermally activated delay fluorescence (TADF) emitters in the orange-red regime usually suffers from the fast non-radiative decay of emissive singlet states (), leading to low emitting efficiency in corresponding organic light-emitting diode (OLED) devices. Although has been quantitatively described by energy gap law, how ultrafast molecular motions are associated with the of TADF emitters remains largely unknown, which limits the development of new strategies for improving the emitting efficiency of corresponding OLED devices. In this work, we employed two commercial TADF emitters (TDBA-Ac and PzTDBA) as a model system and attempted to clarify the relationship between ultrafast excited-state structural relaxation (ES-SR) and .

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Background: Ischemic stroke is a major cause of worldwide death and disability, with recombinant tissue plasminogen activator being the sole effective treatment, albeit with a limited treatment window. The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway is emerging as the major DNA-sensing pathway to invoke immune responses in neuroinflammatory disorders.

Methods: By performing a series of neurobehavioral assessments, electrophysiological analysis, high-throughput sequencing, and cell-based assays based on the transient middle cerebral artery occlusion (tMCAO) mouse stroke model, we examined the effects and underlying mechanisms of genetic and pharmacological inhibition of the cGAS-STING pathway on long-term post-stroke neurological functional outcomes.

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Förster resonance energy transfer (FRET) has been widely applied in fluorescence imaging, sensing and so on, while developing useful strategy of boosting FRET efficiency becomes a key issue that limits the application. Except optimizing spectral properties, promoting orientation factor (κ) has been well discussed but rarely utilized for boosting FRET. Herein, we constructed binary nano-assembling of two thermally activated delayed fluorescence (TADF) emitters (2CzPN and DMAC-DPS) with J-type aggregate of cyanine dye (C8S4) as doping films by taking advantage of their electrostatic interactions.

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Renal fibrosis poses a significant threat to individuals suffering from chronic progressive kidney disease. Given the absence of effective medications for treating renal fibrosis, it becomes crucial to assess the extent of fibrosis in real time and explore the development of novel drugs with substantial therapeutic benefits. Due to the accumulation of renal tissue damage and the uncontrolled deposition of fibrotic matrix during the course of the disease, there is an increase in viscosity both intracellularly and extracellularly.

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Accumulating evidence indicates that paternally-derived miRNAs play a crucial role in the development of early embryos and are regarded as the key factor in the successful development of somatic cell cloned embryos. In our previous study, bta-miR-301a was found to be highly expressed in bovine sperm, and was delivered into oocytes during fertilization. In this study, bioinformatics, dual luciferase reporter assays, rescue experiments and gain- and loss-of-function experiments indicated that ACVR1 is the target gene of bta-miR-301a in early bovine embryos.

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Dopamine receptors have been reported to be involved in pain, while the exact effects and mechanism in bone cancer pain have not been fully explored. Bone cancer pain model was created by implanting walker 256 mammary gland carcinoma into right tibia bone cavity. Primary cultured spinal neurons were used for evaluation.

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China has implemented a series of environmental policies aimed at promoting green and innovative development by enterprises, to mitigate the adverse effects of environmental pollution. However, the frequent revision and introduction of environmental policies have also increased enterprises' perception of environmental uncertainty. This study, based on the upper echelon theory, uses data from listed companies in China from 2011 to 2021 to construct an index of perceived environmental uncertainty of firms through textual analysis and empirically examines its impact on green innovation and its potential mechanisms and boundary effects.

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Strain engineering has been used as an efficient method to modulate various properties of quantum materials and electronic devices. One may establish piezo effects based on a disciplined response to the strain in multifunctional nanosystems. Inspired by a recent theoretical proposal on the interesting piezomagnetism and C-paired valley polarization in the VSeO monolayer, we predict a stable altermagnetic Janus monolayer VSeTeO using density functional theory calculations.

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Uric acid is the final metabolite in humans. High level of uric acid chronically induces urate deposition, aggravates kidney damage, and concomitantly causes an increase in inflammatory factors. Alleviating acute inflammation and decreasing uric acid levels are the key points in the treatment of inflammatory diseases associated with high uric acid.

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The emerging nitrogen-embedded multiple resonance (MR) emitters with an indolo[3,2,1-] carbazole (ICz) unit have exhibited promising performance for high-resolution organic light-emitting diode (OLED) devices, while the underlying photophysics has been rarely reported. In this work, the optical spectra, color purity, and emitting efficiency of ICz-based MR emitters were investigated by using electronic structure and thermal vibration correlation function (TVCF) calculations. Unlike B-N MR emitters, the high color purity of investigated ICz-based MR emitters was mainly contributed by considerable structural rigidity, which also greatly affects the radiative decay rate and fluorescence quantum yield of the S state.

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The hydroxyl radical (•OH) is shown to play a crucial role in the occurrence and progression of acute kidney injury (AKI). Therefore, the development of a robust •OH probe holds great promise for the early diagnosis of AKI, high-throughput screening (HTS) of natural protectants, and elucidating the molecular mechanism of intervention in AKI. Herein, the design and synthesis of an activatable fluorescent/photoacoustic (PA) probe (CDIA) for sensitive and selective imaging of •OH in AKI is reported.

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The emergence of multidrug-resistant bacteria has severely increased the burden on the global health system, and such pathogenic infections are considered a great threat to human well-being. Antimicrobial peptides, due to their potent antimicrobial activity and low possibility of inducing resistance, are increasingly attracting great interest. Herein, a novel dermaseptin peptide, named Dermaseptin-SS1 (SS1), was identified from a skin-secretion-derived cDNA library of the South/Central American tarsier leaf frog, using a 'shotgun' cloning strategy.

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