Enhanced Second-Harmonic Generation in Thin-Film Lithium Niobate Circular Bragg Nanocavity.

Second-order nonlinearity gives rise to many distinctive physical phenomena, e.g., second-harmonic generation, which play an important role in fundamental science and various applications.

Plasmonic hotspot arrays boost second harmonic generation in thin-film lithium niobate.

Focusing light down to subwavelength scales to enhance the light-matter interaction has been highly sought after, which has promoted significant researches and applications in nanophotonics. Plasmonic nanoantennae are a significant tool to achieve this goal since they can confine light into ultra-small volumes far below the diffraction limit. However, metallic materials have the property of central symmetry, resulting in weak second-order nonlinear effects.

The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis.

Methods: The Preferred Reporting Items for Systematic Reviews and Analysis checklist was used. A comprehensive literature search of the PubMed, Embase, and Cochrane Library databases was conducted through August 2022 to assess the impact of probiotics on blood glucose, lipid, and inflammatory markers in adults with prediabetes. Data were pooled using a random effects model and were expressed as standardized mean differences (SMDs) and 95% confidence interval (CI).

Thin-film lithium niobate polarization modulator without polarization diversity.

With the development of photonic integrated circuits and optical information processing on thin-film lithium niobate (TFLN), the realization of the TFLN-based polarization device is becoming more and more crucial. Here, we demonstrate a polarization modulator on the TFLN platform without polarization diversity. Without polarization manipulation elements, the device only composes a phase modulator and a two-dimensional grating coupler.

An Algorithm Framework for Drug-Induced Liver Injury Prediction Based on Genetic Algorithm and Ensemble Learning.

In the process of drug discovery, drug-induced liver injury (DILI) is still an active research field and is one of the most common and important issues in toxicity evaluation research. It directly leads to the high wear attrition of the drug. At present, there are a variety of computer algorithms based on molecular representations to predict DILI.

Active mode selection by defects in lithium niobate on insulator microdisks.

Whispering gallery mode (WGM) optical microcavities are important building blocks in photonic integrated circuits. Operation of such cavities on specific lower- or higher- order transverse modes has much interest in application perspectives. Here, we demonstrate active mode selection by introducing defects in lithium niobate on insulator microdisks.

Effective four-wave mixing in the lithium niobate on insulator microdisk by cascading quadratic processes.

Whispering-gallery-mode resonators can dramatically enhance the light-matter interaction, benefitting nonlinear optics in many ways. Here, we demonstrate effective four-wave mixing (FWM) in a lithium niobate on insulator (LNOI) microdisk via cascaded quadratic nonlinear processes of second-harmonic generation and difference-frequency generation (i.e.

Enhancement of surface plasmon polariton excitation via feedback-based wavefront shaping.

Surface plasmon polariton (SPP) is an electromagnetic excitation with efficient spatial confinement and high local field intensity at a metal/dielectric interface, which has been widely applied in many fields such as nanophotonics, imaging, biosensing, nonlinear optics, and so on. However, the destructive interference, which arises from wavevector mismatching between the spatial components of incident light and SPP, limits the effective excitation of SPP. Here, we experimentally demonstrate the enhancement of SPP excitation via a feedback-based wavefront shaping method in the Kreschmann configuration.

A possible pathogenetic factor of sickle-cell disease based on fluorescent analysis via an optofluidic resonator.

Waveguide based optofluidic resonator features high precision and high sensitivity in real-time fluorescent analysis. We present a novel optofluidic resonator following the hollow-core metal-cladding waveguide structure, which is then used to record the real-time binding process of Fe and Fe with protoporphyrin IX (PpIX) in PBS solution, respectively. The central fluorescent wavelength of compound with Fe is in good accordance with that of the normal hemoglobin, whilst the peaks of the Fe compound match the hemoglobin specimen from sickle-cell disease (SCD) patients.

A clinical trial of acupuncture about time-varying treatment and points selection in primary dysmenorrhea.

Objective: To observe the clinical therapeutic effects of acupuncture at single point Shiqizhui (EX-B8) and multi-points in time-varying treatment for primary dysmenorrhea.

Methods: 600 patients with primary dysmenorrhea were randomly assigned to the single point group (n=200) including group A (treating before the menstruation, n=100) and group B (immediately treating as soon as pain occurrence, n=100), the multi-points group (n=200) including group C (treating before the menstruation, n=100) and group D (immediately treating as soon as pain occurrence, n=100), or the control group, group E (n=200, no treatment). The therapeutic effects were analyzed after treatment for three menstrual cycles and interviewed for three follow-up periods.