Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study.

Background: Cognitive impairment is a common health problem among older adults. Previous studies have proven the association between sleep quality and cognitive impairment, but the specific underlying mechanisms need to be further explored. This study aimed to examine the relationship between sleep quality and cognitive impairment and the mediating effect of frailty in this relationship among the rural older adults.

Boosting Rice Resilience: Role of Biogenic Nanosilica in Reducing Arsenic Toxicity and Defending against Herbivore.

The use of nanoparticles is a promising ecofriendly strategy for mitigating both abiotic and biotic stresses. However, the physiological and defense response mechanisms of plants exposed to multiple stresses remain largely unexplored. Herein, we examined how foliar application of biogenic nanosilica (BNS) impacts rice plant growth, molecular defenses, and metabolic responses when subjected to arsenic (As) toxicity and infested by the insect .

The causal effects of dietary component intake and blood metabolites on risk of delirium: a Mendelian randomization study.

Backgrounds: Growing evidence has indicated that the nutritional quality of dietary intake and alterations in blood metabolites were related to human brain activity. This study aims to investigate the causal relationship between dietary component intake, blood metabolites, and delirium risks.

Methods: We performed Mendelian randomization (MR) analysis using genetic variants as instrumental variables for dietary component intake, blood metabolites, and delirium.

A novel combined oxidative stress and extracellular matrix related predictive gene signature for keratoconus.

Keratoconus (KC) is an ectatic cornea disease with high prevalence and asymptomatic at early stage, leading to decreased visual acuity and even cornea transplantation. However, the etiology mechanism of keratoconus is still poorly understood. Oxidative stress (OS) and extracellular matrix (ECM) remodeling play critical roles in keratoconus development.

Cross-Linked Polyamide-Integrated Argyrodite LiPSCl for All-Solid-State Lithium Metal Batterie.

Lithium dendrite growth has become a significant barrier to realizing high-performance all-solid-state lithium metal batteries. Herein, an effective approach is presented to address this challenge through interphase engineering by using a cross-linked polyamide (negative electrostatic potential) that is chemically anchored to the surface of LiPSCl (positive electrostatic potential). This method improves contact between electrolyte particles and strategically modifies the local electronic structure at the grain boundary.

Outstanding high-temperature capacitive performance in all-organic dielectrics enabled by synergistic optimization of molecular traps and aggregation structures.

Improving the high-temperature performance of polymer dielectrics is critical for the development of advanced electrical systems. The deterioration of the capacitive performance of polymer dielectrics at high electric fields and elevated temperatures is attributable to the exponentially increased conduction loss. Herein, a synergistic strategy of molecular trap and aggregation structure optimization is developed to suppress the conduction loss of polymer dielectrics.

Identification of BocLys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders.

Targeted protein degradation has been emerging as a promising strategy for drug design and a useful tool for the research of intracellular protein function by specifically downregulating the protein level via promoted degradation. Aside from proteolysis targeting chimeras (PROTAC) that utilize a specific E3 ligase ligand as a tag to recruit polyubiquitin onto the targeted protein and subsequently induce degradation, BocArg was also reported an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome. Based on the similarity of BocLys and BocArg, we identified that BocLys also efficiently induced targeted protein degradation, taking glutathione S-transferase as an example.

Oxychloride Polyanion Clustered Solid-State Electrolytes via Hydrate-Assisted Synthesis for All-Solid-State Batteries.

Solid-state electrolytes (SSEs) play a vital role in the development of high-energy all-solid-state batteries. However, most adopted mechanical ball milling and/or high-temperature annealing are ineffective approaches for large-scale synthesis. Herein, a universal and scalable hydrate-assisted strategy for the synthesis of oxychloride SSEs is developed based on the chemical reaction among alkali chlorides, AlCl, and AlCl·6HO.

Observation of Aromatic B(CO) ( = 1-7) as Boron Carbonyl Analogs of Benzene.

CO as a typical σ-donor is one of the most important ligands in chemistry, while planar B is experimentally known as the most prominent magic-number boron cluster analogous to benzene. Joint gas-phase mass spectroscopy, collision-induced dissociation, and first-principles theory investigations performed herein indicate that B reacts with CO successively under ambient conditions to form a series of boron carbonyl complexes B(CO) up to = 7, presenting the largest boron carbonyl complexes observed to date with a quasi-planar B core at the center coordinated by CO ligands around it. Extensive theoretical analyses unveil both the chemisorption pathways and bonding patterns of these aromatic B(CO) monocations which, with three delocalized π bonds well-retained over the slightly wrinkled B moiety, all prove to be boron carbonyl analogs of benzene tentatively named as boron carbonyl aromatics (BCAs).

Chloride accumulation in inland rivers of China and its toxic impact on cotton.

The escalation of major ion concentrations in freshwater and soil poses diverse effects on ecosystems and the environment. Excessive ions can exhibit toxicity to aquatic organisms and terrestrial plants. Currently, research on ion toxicity primarily focuses on cation toxicity.

An inverted U-shaped relationship between work-family conflict and job burnout among village clinic doctors: the moderating effect of information and communication technology use.

Background: Village clinic doctors are an integral part of the rural healthcare workforce. With the advancement of science and technology and the coronavirus disease 2019 (COVID-19) pandemic, the prevalence of remote work and the use of information and communication technologies (ICT) have increased significantly. However, these developments have also had an impact on the work family balance and mental well-being of village clinic doctors.

Multi-modal feature fusion with multi-head self-attention for epileptic EEG signals.

It is important to classify electroencephalography (EEG) signals automatically for the diagnosis and treatment of epilepsy. Currently, the dominant single-modal feature extraction methods cannot cover the information of different modalities, resulting in poor classification performance of existing methods, especially the multi-classification problem. We proposed a multi-modal feature fusion (MMFF) method for epileptic EEG signals.

A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks.

The cornea is a vital tissue of the human body. The health status of the cornea has a great impact on the quality life of person. There has been a great deal of research on the human cornea biomechancis.

Preferences of patients with multiple chronic diseases for medication in rural areas of an Eastern Province China: a discrete choice experiment.

Background: Multiple Chronic Diseases (MCD) are the co-occurrence of two or more chronic conditions within an individual. Compared to patients with a single chronic disease, those with MCD face challenges related to polypharmacy, which increases the risk of adverse drug events, side effects, and drug-drug interactions. Understanding the specific medication preferences of patients with MCD is crucial to optimize treatment plans and enhance treatment safety.

The Prevalence of Depression among the Global Public in the Context of the COVID-19 Epidemic: A Systematic Review and Meta-Analysis.

Background: We aimed to analyze the prevalence of depression among the global public during COVID-19, identify its influencing factors in order to provide reference, and help safeguard public mental health.

Methods: A comprehensive literature on global public depression in various countries during the COVID-19 pandemic was obtained through electronic searches of PubMed, Web of Science, and other databases, combined with literature tracing from Dec 2019 to Mar 2023. Then a meta-analysis was conducted using the random effects model by Stata 16.

Aspirin enhances radio/chemo-therapy sensitivity in C. elegans by inducing germ cell apoptosis and suppresses RAS overactivated tumorigenesis via mtROS-mediated DNA damage and MAPK pathway.

Previous studies have demonstrated that combination therapy involving radiotherapy and aspirin decreases the survival rate of cancer cells. However, the mechanism by which aspirin exerts its radiation sensitization effect at the in vivo level remains largely unclear. In this study, we employed Caenorhabditis elegans (C.

Selective Reduction of NO into N Catalyzed by the RhMO Clusters (M = Ta, V, and Al): Importance of the Triatomic Lewis Acid-Base-Acid M-Rh-M Site.

Catalytic NO reduction by CO into N and CO is imperative owing to the increasingly rigorous emission regulation. Identifying the nature of active sites that govern the reactivity and selectivity of NO reduction is pivotal to tailor catalysts, while it is extremely challenging because of the complexity of real-life systems. Guided by our newly discovered triatomic Lewis acid-base-acid (LABA, Ce-Rh-Ce) site that accounts for the selective reduction of NO into N catalyzed by the RhCeO cluster in gas-phase experiments, the reactivity of the RhMO (M = Ta, V, and Al) clusters in catalytic NO reduction by CO was explored.

Trophic Transfer of Metal Oxide Nanoparticles in the Tomato- Food Chain: Effects on Phyllosphere Microbiota, Insect Oxidative Stress, and Gut Microbiome.

Understanding the trophic transfer and ecological cascade effects of nanofertilizers and nanopesticides in terrestrial food chains is crucial for assessing their nanotoxicity and environmental risks. Herein, the trophic transfer of LaO (nLaO) and CuO (nCuO) nanoparticles from tomato leaves to (Lepidoptera: Noctuidae) caterpillars and their subsequent effects on caterpillar growth and intestinal health were investigated. We found that 50 mg/L foliar nLaO and nCuO were transferred from tomato leaves to , with particulate trophic transfer factors of 1.