PCOS Influences the Expression of AMHRII in the Endometrium of AEH During the Reproductive Age.

Background: Endometrial proliferative lesions (EPLs) encompass endometrial hyperplasia (EH) and endometrial carcinoma (EC). Atypical endometrial hyperplasia (AEH) is associated with an elevated risk of progression to EC. Patients with polycystic ovarian syndrome (PCOS) exhibit higher serum levels of anti-Müllerian hormone (AMH) and a correspondingly increased incidence of EPLs.

Safety and clinical efficacy of neoadjuvant chemoradiation therapy with immunotherapy for organ preservation in ultra-low rectal cancer: preliminary results of the CHOICE-I trial: a prospective cohort study.

Objective: To explore the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) combined with a PD-1 antibody in improving complete clinical response (cCR) and organ preservation in patients with ultra-low rectal cancer.

Methods: This was a prospective phase II, single-arm, open-label trial. Patients with confirmed pMMR status T1-3aN0-1M0 retcal adenocarcinoma were included.

A fast-modeling framework for personalized human body models based on a single image.

Finite element human body models (HBMs) are the primary method for predicting human biological responses in vehicle collisions, especially personalized HBMs that allow accounting for diverse populations. Yet, creating personalized HBMs from a single image is a challenging task. This study addresses this challenge by providing a framework for HBM personalization, starting from a single image used to estimate the subject's skin point cloud, the skeletal point cloud, and the relative positions of the skeletons.

Tracing Sentinel Lymph Nodes and Inhibiting Lymphatic Metastasis with TiN Nanobipyramids Through Photothermal Therapy.

Background: The lymphatic system is the major route of cancer metastasis, and sentinel lymph nodes (SLNs) are the first station for the spread of cancer cells. Accurate identification of SLNs by tracers during surgery is crucial for SLN biopsy and lymphadenectomy. However, conventional monomodal tracers such as blue dyes and carbon nanoparticles often induce a misjudgment of SLNs and thus are still unsatisfying for clinical applications.

Cardiometabolic Index is associated with heart failure: a cross-sectional study based on NHANES.

Introduction: Heart failure is a complex syndrome characterized by impaired cardiac function. Despite improvements in treatment, the prevalence of heart failure continues to rise. The Cardiometabolic Index (CMI), a novel measure combining abdominal obesity and lipid levels, has emerged as a potential predictor of cardiac metabolic risk.

Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.

Aims/introduction: Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound-healing processes. Interleukin-37 (IL-37) is a natural suppressor of innate inflammation. Here, we aim to investigate the potential of IL-37 in enhancing the healing process of diabetic wounds.

Synthesis, Structure, and Properties of 2D Lanthanide(III) Coordination Polymers Constructed from Cyclotriphosphazene-Functionlized Hexacarboxylate Ligand.

The design and synthesis of novel lanthanide-based coordination polymers (Ln-CPs) from flexible organic ligands is still attractive and challenging. In this work, two isostructural Ln-CPs with a unique 2D network, namely, [Ln(HL)(DMF)]] (Ln = Dy for , Tb for ) based on a flexible polycarboxylic acid ligand hexakis(4-carboxylato-phenoxy)cyclotriphosphazene (HL), have been solvothermally synthesized and structurally characterized. Significantly, it is the first observation of polycarboxylic acid ligands participating in coordination in the construction of coordination polymers in the form of semi-deprotonation.

Dietary carbohydrate to lipid ratio affects growth, reproductive performance and health of female yellow catfish (): A lipidomics analysis.

This study aimed to examine the impact of dietary carbohydrate to lipid (CHO/L) ratio on the growth, reproductive, and offspring performance of broodstock yellow catfish, and to elucidate the metabolic differences between mothers and offspring using lipidomics. Five isonitrogenous and isoenergetic diets with varying CHO/L ratios (0.65, 1.

Phosphorus removal in microalgal growth and harvesting using natural flocculant: Influence of microalgal characteristics and phosphorus forms.

Phosphorus-induced harmful algae blooms elicited attention, and both microalgae harvesting and phosphorus removal are essential, especially preventing secondary pollution. In this study, starved Chlorella vulgaris removed 68.73 % of dissolved inorganic phosphorus (DIP) compared to 37.

Effects of the Replacement of Dietary Fishmeal by the Blend of Meal, Meal, Protein, and Cottonseed Protein Concentrate on Growth, Protein Utilization, and Intestinal Health of Gibel Carp (, CAS Ⅴ).

The trial was conducted to investigate the effects of the replacement of dietary fishmeal (FM) by the blend of meal (TMM), meal (CM), protein (CAP), cottonseed protein concentrate (CPC) on growth, protein utilization and intestinal health of gibel carp (, CAS Ⅴ). The FM-based diet was used as the control, and the blended proteins (TMM: CM: CAP: CPC) at ratios of 1 : 1:8 : 2 (BLEND A), 1 : 1:6 : 4 (BLEND B), and 1 : 1:4 : 6 (BLEND C) were used to replace FM at three levels (33%, 67%, 100%), respectively. The results showed that, compared to the control group, growth performance increased significantly when dietary FM was fully replaced by BLEND B ( < 0.

Carbon fate and potential carbon metabolism effects during in-situ cyanobacterial inhibition by artemisinin sustained-release algaecides.

Carbon pools and microbial carbon metabolism can be significantly altered due to the diverse organic matter properties and low pH characteristics of artemisinin sustained-release algaecides (ASAs). These effects have still not been systematically studied, leading to uncertainty in the application of ASAs for cyanobacterial management in natural waters. This study assessed the effects of ASAs on carbon fate, carbon metabolism and potential ecological impacts during in-situ cyanobacterial inhibition.

Dual modification of cobalt silicate nanobelts by CoO nanoparticles and phosphorization boosting oxygen evolution reaction properties.

Oxygen evolution reaction (OER) process is the "bottleneck" of water splitting, and the low-cost and high-efficient OER catalysts are of great importance and attractive but they are still challenging. Herein, a dual modification strategy is developed to tune and enrich the structure of cobalt silicate (CoSiO) showing boosted OER properties. Cobalt oxide (CoO) decorated CoSiO nanobelts, denoted as CS, is firstly prepared using a Co-based precursor by a facile hydrothermal reaction.

Characterization of the Metabolic Proteome of Serum From Patients With Diabetic Distal Symmetric Polyneuropathy.

Aims: The pathophysiological of diabetic distal symmetric polyneuropathy (DSPN) remains to be elucidated and there are no diagnostic or prognostic biomarkers for the condition. In this explorative proteomic study, metabolic proteome profiling of serum in patients with/without DSPN was analyzed. We aimed to discover proteins with different abundance ranges through proximity extension assay (PEA) technology.

Biotransformation of aquaculture wastewater into aquatic feed protein source: Chlorella sorokiniana nutritional value and safety risk assessment.

Aquaculture wastewater contains high concentrations of nitrogen and phosphorus compounds, which can be used as nutrients for microalgal growth. In this study, the ability of Chlorella sorokiniana (C. sorokiniana) to purify aquaculture wastewater from an intensive recirculating aquaculture system (RAS) carp sp.

Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasis.

Metastasis is the main cause of mortality in colorectal cancer (CRC) patients. Exploring the mechanisms of metastasis is of great importance in both clinical and fundamental CRC research. CRC is a highly heterogeneous disease with variable therapeutic outcomes of treatment.

The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores.

Fish show variation in feeding habits to adapt to complex environments. However, the genetic basis of feeding preference and the corresponding metabolic strategies that differentiate feeding habits remain elusive. Here, by comparing the whole genome of a typical carnivorous fish ( Günther) with that of herbivorous fish, we identify 250 genes through both positive selection and rapid evolution, including taste receptor () and We demonstrate that is required for carnivore preference in -deficient zebrafish and in a diet-shifted grass carp model.

Association between dietary intake of niacin and stroke in the US residents: evidence from national health and nutrition examination survey (NHANES) 1999-2018.

Objective: This study aims to explore the association between niacin intake and stroke within a diverse, multi-ethnic population.

Methods: A stringent set of inclusion and exclusion criteria led to the enrollment of 39,721 participants from the National Health and Nutrition Examination Survey (NHANES). Two interviews were conducted to recall dietary intake, and the USDA's Food and Nutrient Database for Dietary Studies (FNDDS) was utilized to calculate niacin intake based on dietary recall results.

Chiral Star-Shaped [CoLn] Clusters with Enantiopure Schiff Bases: Synthesis, Structure, and Magnetism.

Two enantiomeric pairs of new 3d-4f heterometallic clusters have been synthesized from two enantiomer Schiff base derivatives: (/)-2-[(2-hydroxy-1-phenylethylimino)methyl] phenol (-/-HL). The formulae of the series clusters are CoLn(-L) (Ln = Dy (), Gd ()), CoLn (-L) (Ln = Dy (), Gd ()), whose crystal structures and magnetic properties have been characterized. Structural analysis indicated that the above clusters crystallize in the chiral 23 group space.

WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer.

Protein tyrosine phosphatase SHP2 activates RAS signaling, which is a novel target for colorectal cancer (CRC) therapy. However, SHP2 inhibitor monotherapy is ineffective for metastatic CRC and a combination therapy is required. In this study, we aimed to improve the antitumor efficacy of SHP2 inhibition and try to explore the resistance mechanism of SHP2 inhibitor.