Highly Sensitive T-Shaped Quartz Tuning Fork Based CH-Light-Induced Thermoelastic Spectroscopy Sensor with Hydrogen and Helium Enhanced Technique.

In this paper, a highly sensitive methane (CH) sensor based on light-induced thermoelastic spectroscopy (LITES) and a T-shaped quartz tuning fork (QTF) with hydrogen (H) and helium (He) enhancement techniques are reported for the first time. The low resonant frequency self-designed T-shaped QTF was exploited for improving the energy accumulation time. H and He were utilized as surrounding gases for the T-shaped QTF to minimize energy loss, thereby enhancing the sensitivity of the LITES sensor.

Long-term surgical outcomes of combined Ahmed glaucoma valve implantation and phacoemulsification with intraocular lens implantation for patients with glaucoma secondary to iridocorneal endothelial syndrome.

Background: To assess the long-term outcomes of patients with glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE) who underwent Ahmed glaucoma valve (AGV) implantation combined with phacoemulsification and intraocular lens (IOL) implantation surgery.

Methods: In this non-comparative retrospective case series study, twelve patients with uncontrolled GS-ICE and cataract underwent Ahmed aqueous shunt combined with phacoemulsification and IOL implantation surgery at Beijing Tongren Eye Center between June 2014 and June 2022. Main medical records included best-corrected visual acuity (BCVA), intraocular pressure (IOP), number of antiglaucoma medications (AGM), corneal status and further surgical interventions.

Effects of Pulse Interval on Forming Process in Wire Arc Metal Additive Manufacturing Using Pulsed Arc Plasma.

To overcome the material processing challenges induced by high levels of heat input in wire arc additive manufacturing (WAAM), an innovative WAAM method using pulsed arc plasma (PAP-WAAM), was developed by the authors in the previous study. In this method, the PAP generated by the pulsed voltage was used as the heat source. The pulse interval can be defined as the time interval between adjacent pulse voltages, which determines the ignition time and frequency of the arc plasma, thus influencing the forming process.

2.09 µm high-gain, high-energy sub-nanosecond laser amplification system and its application to a millijoule-level mid-infrared ZnGeP optical parametric generator.

In this Letter, we report for the first time to our knowledge a 2 mJ-level 2.09 µm Ho:YAG regenerative amplifier (RA) seeded by the first-stage Ho-doped fiber (HDF) preamplifier of a gain-switched laser diode (GSLD). After the single-pass power amplifier (SPPA), the output of a 2.

Narrowband mid-infrared optical parametric generator based on a type-II BaGaSe crystal.

In this Letter, we first reported on a mid-infrared double-pass optical parametric generator (OPG) based on a single type-II phase-matching BaGaSe (BGSe) crystal, pumped at 2.1 µm. The OPG achieved a maximum pulse energy of 55 µJ for generating narrowband mid-infrared laser pulses.

Hybrid Additive and Subtractive Manufacturing Method Using Pulsed Arc Plasma.

In this study, a novel hybrid additive and subtractive manufacturing method using pulsed arc plasma (PAP-HASM) was developed to better integrate additive and subtractive processes. The PAP-HASM process is based on the flexible application of pulsed arc plasma. In this PAP-HASM method, wire arc additive manufacturing using pulsed arc plasma (PAP-WAAM) and dry electrical discharge machining (EDM) milling were used as additive and subtractive techniques, respectively; both are thermal machining processes based on pulsed arc plasma, and both are dry machining techniques requiring no working fluids.

Additive manufacturing of geopolymers with hierarchical porosity for highly efficient removal of Cs.

Geopolymers (GPs) have emerged as promising adsorbents for wastewater treatment due to their superior adsorption stability, tunable porosity, high adsorption capacity, and low-energy production. Despite their great promise, developing GPs with well-controlled hierarchical structures and high porosity remains challenging, and the mechanism underlying the ion adsorption process remains elusive. Here we report a cost-effective and universal approach to fabricate Na or K GPs with sophisticated architectures, high porosity, and arbitrary cation species exchange by means of additive manufacturing and a surfactant.

113 W Ho:YLF oscillator with good beam quality efficiently pumped by a Tm:YAP laser.

We demonstrate a linearly polarized Tm:YAP slab laser pumped by fiber-coupled laser diodes. The maximum output power is 202 W at 1937.5 nm with a slope efficiency of 47.

Thermal-birefringence-induced depolarization in a 450 W Ho:YAG MOPA system.

We demonstrated an efficient, high-power Ho:YAG master-oscillator power amplifier (MOPA) system and investigated its thermal-birefringence-induced depolarization. The maximum output power was 450 W with a depolarized power of 32.1 W and depolarization of 0.

Combination of Trabeculectomy and Primary Pars Plana Vitrectomy in the Successful Treatment of Angle-Closure Glaucoma with BEST1 Mutations: Self-Controlled Case Series.

Introduction: This study aimed to illustrate the efficacy of the combination of lens extraction, trabeculectomy, and anterior vitrectomy in patients with secondary angle-closure glaucoma (ACG) with autosomal recessive bestrophinopathy or Best vitelliform macular dystrophy.

Methods: This is a retrospective self-controlled case series study. Five patients undergoing a single trabeculectomy in one eye and triple surgery in the other eye were enrolled.

Tm: BiSiO crystal as a promising laser material near 2 μm: growth, spectroscopic properties and laser performance.

We report on the crystal growth, spectroscopic properties and laser performance of Tm-doped BiSiO (BSO) crystal. The crystal was grown by the vertical Bridgeman method. The spectroscopic properties are investigated based on absorption and luminescence spectroscopy.

Passively Q-switched Tm:YAP laser with a lead zirconate titanate saturable absorber.

In the paper, we prepare a lead zirconate titanate saturable absorber, which is used to demonstrate a passively -switched (PQS) Tm:YAP laser. In the PQS mode, an average output power of 0.81 W and pulse width of 1.

Design and synthesis of novel substituted benzyl pyrrolopyrimidine derivatives as selective BTK inhibitors for treating mantle cell lymphoma.

Ibrutinib, a potent irreversible Bruton's tyrosine kinase (BTK) inhibitor, was approved by the FDA for treating mantle cell lymphoma (MCL). Although ibrutinib exhibited excellent antitumor activity, it was associated with certain adverse reactions, with off-target effects against EGFR, Itk and Src family kinases. Our studies yielded a novel series of substituted benzyl pyrrolopyrimidine derivatives capable of potent inhibition of BTK.

High-power actively Q-switched Ho-doped gadolinium tantalate laser.

In this paper, we present the acousto-optical (AO) Q-switched performance of a holmium (Ho):gadolinium tantalate (GdTaO) (Ho:GTO) laser pumped by a thulium (Tm)-fiber laser emitting at 1.94 µm. In the efficient continuous wave (CW) regime, a maximum output power of 30.

Design, Synthesis and Biological Evaluation of 1-methyl-1H-pyrazole-5-Carboxamide Derivatives as Novel Anti-Prostate Cancer Agents.

Background: The Androgen Receptor (AR) signaling functionis a critical driving force for the progression of Prostate Cancer (PCa) to bring about anti-prostate cancer agents, and AR has been proved to be an effective therapeutic target even for Castration-Resistant Prostate Cancer (CRPC).

Objective: In order to discover novel anti-prostate cancer agents, we performed structural modifications based on the lead compounds T3 and 10e.

Methods: A set of 1-methyl- 1H-pyrazole-5-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against both expressions of Prostate-Specific Antigen (PSA) and growth of PCa cell lines.

Clinical characteristics, rates of blindness, and geographic features of PACD in China.

Objective: To analyze the rates of blindness with the demographics and clinical characteristics of patients with primary angle-closure disease (PACD) to provide a comprehensive epidemiologic reference in China.

Methods: A retrospective analysis was conducted in the Chinese Glaucoma Study Consortium database, which is a national multicenter glaucoma research alliance of 111 hospitals participating between December 21, 2015 and September 9, 2018. The diagnosis of PACD was made by qualified physicians through examination.

161 W middle infrared ZnGeP MOPA system pumped by 300 W-class Ho:YAG MOPA system.

We demonstrated a high-power -switched two-stage Ho:YAG master-oscillator power-amplifier (MOPA) system dual-end pumped by Tm:YLF lasers. A new method was introduced by rotating and swapping spatial axial directions of pump beams to improve the beam quality of the Ho:YAG oscillator and first-stage amplifier. Two parallel second-stage Ho:YAG amplifiers were employed to output high power.

Continuously tunable high-power single-longitudinal-mode Ho:YLF laser around the P12 CO absorption line.

A continuously tuned single-longitudinal-mode (SLM) Ho:YLF laser around the P12 absorption line was demonstrated. The continuous tuning range of 5.75 pm within one longitudinal mode spacing of the Ho:YLF resonator was realized by using a novel intra-cavity wedge prism device fixed on the piezoelectric transducer (PZT) as the cavity length controller.

Research on performance improvement technology of a BaGaSe mid-infrared optical parametric oscillator.

In this Letter, we demonstrate an average output power of 5.12 W at 3-5 µm from a type-I phase-matching (BGSe) optical parametric oscillator (OPO), which is pumped by a 2090 nm -switched Ho:YAG laser with pulse repetition frequency of 1 kHz. At maximum output level, the corresponding slope efficiency and optical-to-optical conversion efficiency are 30.

Tunable twisted-mode Ho:YAG laser at continuous-wave and pulsed operation.

A single-longitudinal-mode Ho:YAG laser with a twisted-mode cavity under the continuous-wave and pulsed operation was demonstrated. The maximum continuous-wave single-longitudinal-mode output power of 0.76 W was obtained at the wavelength of 2097.

570 MHz harmonic mode-locking in an all polarization-maintaining Ho-doped fiber laser.

In this paper, we demonstrate a 570.0 MHz harmonically mode-locked all-polarization-maintaining Ho-doped fiber laser based on semiconductor saturable absorbed mirror. Firstly, the laser operates in the 15.

Atomically Thin Hexagonal Boron Nitride and Its Heterostructures.

Atomically thin hexagonal boron nitride (h-BN) is an emerging star of 2D materials. It is taken as an optimal substrate for other 2D-material-based devices owing to its atomical flatness, absence of dangling bonds, and excellent stability. Specifically, h-BN is found to be a natural hyperbolic material in the mid-infrared range, as well as a piezoelectric material.

High-beam-quality 2.1 µm pumped mid-infrared type-II phase-matching BaGaSe optical parametric oscillator with a ZnGeP amplifier.

We firstly demonstrated a tunable 2.1 µm pumped mid-infrared type-II phase-matching (BGSe) optical parametric oscillator (OPO). A signal tuning range of 3.