The relationship between resilience and mental health: mobile phone dependence and its differences across levels of parent-child conflict among left-behind adolescents: a cross-sectional network analysis.

Background: Mobile phone dependence and mental health problems have become increasingly prominent among left-behind adolescents in China. In recent years, some studies have focused on the important role of parent-child relationship and psychological resilience. Therefore, this study aims to explore the multidimensional relationships among resilience, mental health, and mobile phone dependence among left-behind adolescents, and to assess the impact of parent-child conflict level on these relationships.

Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis.

We performed a meta-analysis to assess the role of vitamins in the possible pathogenesis and treatment of RLS (Restless Leg Syndrome). A systematic search of the PubMed, Cochrane, Embase, and Web of Science databases was conducted. Fifty-nine studies on the relationship between vitamins and RLS were included, as well as four randomized controlled trials (RCTs) on vitamin treatment of RLS.

Minimal stimulus strategy for diagnosis and treatment of BPPV: a virtual simulation study.

Background: Benign Paroxysmal Positional Vertigo (BPPV) is a common vestibular disorder typically diagnosed and treated through head movements, which can cause discomfort for patients. More importantly, a significant cause of treatment failure is the patient's inability to tolerate these maneuvers.

Objective: To improve patient comfort while maintaining clinical efficacy, this study proposes a Minimal Stimulation Strategy (MSS), utilizing a modified Gufoni maneuver an immediate modified Epley maneuver for BPPV diagnosis and treatment.

Corrigendum: Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.

[This corrects the article DOI: 10.3389/fendo.2024.

Recent Advances in ZIF Membrane: Fabrication, Separation Ability and Its Application.

With the growth of the population and the development of industry and agriculture, water resources are experiencing contamination by numerous pollutants, posing a threat to the aquatic environment and human health. Zeolitic imidazolate framework (ZIF) membranes, as a solution for water pollutant treatment, not only have the advantages of high efficiency adsorption, good selectivity, stability, and easy recyclability, but they also can be modified or derivatized through surface functionalization, compositing, or structural tuning, which can further endow the membranes with other functions, such as catalysis and degradation. In order to improve the performance of ZIF membranes, it is crucial to select suitable preparation methods to optimize the microstructure of the membranes and to improve the separation performance and stability of the membranes.

Advances of functional nucleic acids based on specific recognition:A review.

Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis.

A spatiotemporal distribution prediction model for electric vehicles charging load in transportation power coupled network.

With increasing demand of electric vehicles (EVs), problems such as insufficient EV charging piles and unreasonable layout of EV charging stations are also becoming prominent. New challenges are introduced to the planning of urban EV charging infrastructures. To effectively plan the charging facilities, accurately predicting EV charging loads is essential.

Disrupted Cross-Scale Network Associated With Cognitive-Emotional Disorders in Sudden Sensorineural Hearing Loss.

Background: Sudden sensorineural hearing loss (SSNHL) is associated with abnormal changes in the brain's central nervous system. Previous studies on the brain networks of SSNHL have primarily focused on functional connectivity within the brain. However, in addition to functional connectivity, structural connectivity also plays a crucial role in brain networks.

Neurovascular coupling dysfunction associated with inflammatory factors in sudden sensorineural hearing loss.

Purpose: The neuropathologic mechanisms of sudden sensorineural hearing loss (SSNHL) are unknown. The aim of this study was to investigate the alterations of neurovascular coupling (NVC) in patients with SSNHL and its association with hematologic inflammatory factors.

Methods: The amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were calculated in 48 patients with SSNHL and 54 age-, gender-, and education-matched healthy control (HC), and also utilized the arterial spin labeling imaging (ASL) to calculate cerebral blood flow (CBF).

Facile synthesis of flower-cluster ZIF nanocarriers: Performance in controlled release of thiamethoxam and insecticidal activity.

At present, it is highly important to develop nanopesticide, which can improve the effect of pesticides and reduce the risks of environmental. Zeolitic imidazolate framework (ZIF) is usually used as a nanocarrier of nanopesticide, which has a porous structure and stimuli-responsive properties. However, the drug loading performance and stability of ZIF are poor.

Impaired network organization in mild age-related hearing loss.

Age-related hearing loss (ARHL) is considered one of the most common neurodegenerative disorders in the elderly; however, how it contributes to cognitive decline is poorly understood. With resting-state functional magnetic resonance imaging from 66 individuals with ARHL and 54 healthy controls, group spatial independent component analyses, sliding window analyses, graph-theory methods, multilayer networks, and correlation analyses were used to identify ARHL-induced disturbances in static and dynamic functional network connectivity (sFNC/dFNC), alterations in global network switching and their links to cognitive performances. ARHL was associated with decreased sFNC/dFNC within the default mode network (DMN) and increased sFNC/dFNC between the DMN and central executive, salience (SN), and visual networks.

Cortex Dictamni induces retinitis pigmentosa in zebrafish by inhibiting pde6a post-transcriptional activity via mmu-mir-6240-p3_2.

Ethnopharmacological Relevance: Cortex Dictamni (CD) is the dried root skin of Dictamnus dasycarpus Turcz, widely used in the field of traditional Chinese medicine. Recent adverse reactions to CD limited the clinical application in combination with other traditional Chinese medicines.

Aim Of The Study: To investigate the retinitis pigmentosa (RP) effects of CD using the zebrafish model and elucidate the underlying molecular mechanism of CD-induced RP in zebrafish.

Engineering of peptide assemblies for adaptable protein delivery to achieve efficient intracellular biocatalysis.

Efficient intracellular delivery of native proteins remains a big challenge, which greatly hinders the development of protein therapy. Here, we report a generalizable peptide vector that can encapsulate and deliver various proteins to achieve efficient intracellular biocatalysis. The peptide was rationally designed to be cationic amphiphilic peptide that consist of four functional fragments, that is, a hydrophobic domain to promote molecular assembly, an enzyme-cleavable fragment to introduce stimuli-responsibility, several cationic arginine (Arg) residues to enhance cell interaction and transmembrane efficiency, and the cystine (Cys) residues with redox sensitivity to adjust the stability of the peptide/protein complexes as needed.

Effects of repetitive transcranial magnetic stimulation combined with cognitive training for improving response inhibition: A proof-of-concept, single-blind randomised controlled study.

Background: Impaired response inhibition is a common characteristic of various psychiatric disorders. Cognitive training (CT) can improve cognitive function, but the benefits may be limited. Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to enhance neuroplasticity, and thereby augment the effects of CT.

Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity.

Major challenges of chimeric antigen receptor (CAR)-T cell therapy include poor antigen sensitivity and cell persistence. Here, we report a solution to these issues by exploiting CAR phase separation. We found that incorporation of an engineered T cell receptor CD3ε motif, E, into the conventional 28Z or BBZ CAR induced self-phase separation through cation-π interactions.

Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.

Objective: This study integrates network pharmacology and metabolomics techniques to explore the potential regulatory mechanisms of Res on gouty arthritis (GA).

Methods: Network pharmacology was used to predict the mechanism of Res in regulating GA, and methods such as HE staining, ELISA, immunohistochemistry, Real-time PCR, Western blot, and molecular docking were used to verify the role of NF-κB, MAPK, and JAK/STAT inflammatory signaling pathways in the MSU-induced GA rat model. In addition, non-targeted metabolomics techniques were combined to further investigate the mechanism of Res in treating GA.

Peripheral molecular and brain structural profile implicated stress activation and hyperoxidation in methamphetamine use disorder.

Aim: Methamphetamine use disorders (MUDs) cause widespread disruptions in metabolomic and immunologic processes, highlighting the need for new therapeutic approaches. The purpose of this study was to find molecular and neuroimaging biomarkers for methamphetamine addiction.

Methods: In this study, we recruited 231 patients with MUD at varying stages of withdrawal and 40 healthy controls to quantify the blood levels of 52 molecules using enzyme-linked immunosorbent assay.

Fabrication of Novel Porous Nano-pesticides by Modifying MPN onto Cu-TCPP MOFs to Enhance Bactericidal Efficacy and Modulate Its Bioavailability.

Nano-pesticides have attracted much attention in the field of agriculture, due to existing problems such as decreased bactericidal effect and poor adhesion. An environmentally friendly metal porphyrin (Cu-TCPP)-based nanocarrier pesticide release of diniconazole (DIN) was designed to enhance bactericidal efficacy and modulate its bioavailability in a multidimensional manner by constructing a metal phenolic network (MPN) encapsulation. The introduction of the MPN prevents the DIN from prematurely escaping from the Cu-TCPP@DIN@MPN in the environment and gives it strong interfacial adhesion to resist rain washing.

Structural and covariance network alterations of the hippocampus and amygdala in congenital hearing loss children.

Objective: The hippocampus and amygdala, as important components of the limbic system, play crucial roles in central remodeling in congenital hearing loss. This study aimed to investigate the morphological integrity and network properties of the subfields of hippocampus and amygdala in children with congenital hearing loss.

Methods: A total of 24 children with congenital hearing loss and 17 age- and sex- matched healthy controls (HC) are included in the study.

Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis.

Ferroptosis is a newly identified type of cell death which is strongly linked to the development of several diseases. Whereas, the role of ferroptosis in the improvement of ethanol-induced hepatocytes injury by selenium has not been confirmed. In this study, an in vitro cell damage model was established using half inhibition concentration of ethanol to induce NCTC clone 1469.