Study on the mechanism of acupuncture to improve mild cognitive impairment in hypertension by regulating intestinal microbiome.

High blood pressure is a significant risk factor for cardiovascular diseases and is linked to an increased risk of mild cognitive impairment (MCI). The lack of effective treatments for these conditions highlights the urgent need for novel therapeutic approaches. Recent research suggests that the gut microbiota-brain-gut axis plays a crucial role in the pathogenesis of hypertension and MCI by regulating the nervous, endocrine, and immune systems.

Mechanisms of inflammation modulation by different immune cells in hypertensive nephropathy.

Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease (ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions of intrarenal arterioles and arterioles, luminal stenosis, secondary ischemic renal parenchymal damage, and glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Studying the pathogenesis of hypertensive nephropathy is a prerequisite for diagnosis and treatment.

Fire acupuncture for anti-LGI1 antibody autoimmune encephalitis: a case report.

Autoimmune encephalitis, a class of encephalitis, is clinically characterized by multifocal or diffuse brain injury, including aberrant mental behavior, convulsions, and near-event memory impairment. In this article, we describe a female patient with autoimmune encephalitis who tested positive for leucine-rich glioma inactivated 1 (LGI1) antibodies and had hippocampal inflammatory edema in the lesion area. During the first 3 months of her illness, the patient primarily experienced memory loss, the onset of rigid twitching in her extremities that lasted for 1 min while in remission, and incontinence.

Large-scale mRNA transfer between (Chenopodiaceae) and herbaceous root holoparasite (Orobanchaceae).

Exchanges of mRNA were shown between host and stem parasites but not root parasites. (Orobanchaceae) is a holoparasitic herb which parasitizes on the roots of woody plant (Chenopodiaceae). We used transcriptome sequencing and bioinformatic analyses to identify nearly ten thousand mobile mRNAs.

Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/-Catenin.

Colon cancer is a common malignant disease with high morbidity and mortality, and miRNA dysfunction has been confirmed as an important reason for cancer development. Several studies have verified miR-605-3p as a tumor inhibitor while its roles in colon cancer remain uncertain. In this study, the specimen of the patients and the cell lines of colon cancer were used to observe the expression of miR-605-3p, and the CCK-8, Transwell assay, and flow cytometry assay were used to observe the functions of miR-605-3p in colon cancer cells.

Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture.

Hypertension is one of the primary risk factors for cardiovascular diseases. Numerous proteins serve a critical role in hypertension. Acupuncture has been widely used as a treatment for hypertension in China.

Suppressive effects of RASAL2 on renal cell carcinoma via SOX2/ERK/p38 MAPK pathway.

Metastatic renal cell carcinoma (RCC) is associated with poor prognosis. Ras protein activator like 2 (RASAL2) protein has been previously demonstrated to serves as a tumor suppressor in a variety of malignancies. Therefore, the aim of the present study was to investigate the role of RASAL2 in RCC.

[Origin and relationship of -well points and Shixuan (EX-UE 11)].

Both the twelve -well points and Shixuan (EX-UE 11) are the commonly used first-aid points. These two kinds of acupoints are located closely and similar in function, hence, they are often confused in application. In order to explore the origin of their location and theory as well as their relationship, the relevant data were retrieved.

[Acupuncture strategy for - in ].

This article focuses on the - (the disease has not been cured after treatment) recorded in the and discusses four aspects, including acupuncture feasibility, acupuncture treatment transformation, acupuncture point selection and acupuncture treatment principles. We hope to explain the virtual acupuncture in the from a deeper level and provide new ideas for clinical acupuncture treatment.

[Exploration into the simplex reinforcing-reducing manipulation of acupuncture].

Four controversial types of simplex reinforcing-reducing manipulation of acupuncture and their possible meanings were summarized to explore several key elements of reinforcing-reducing manipulation of acupuncture, in addition, the simplex reinforcing-reducing manipulation of acupuncture was classified by single factor. It is concluded that the definition of simplex reinforcing-reducing manipulation of acupuncture should try not to include other non-manipulative elements. According to single factor, it can be divided into: needle-oriented reinforcing-reducing manipulation, twisting reinforcing-reducing manipulation, lifting and interpolating reinforcing-reducing manipulation, fast and slow reinforcing-reducing manipulation, breathing reinforcing-reducing manipulation, opening and closing reinforcing-reducing manipulation.

Aluminum chelates supported by β-quinolyl enolate ligands: synthesis and ROP of ε-CL.

Treatment of tautomers of β-quinolyl ketone-enaminones with AlMe3 afforded β-quinolyl enolato dialkylaluminium complexes LAlMe2 (L = [(2-C9H6N)-CH[double bond, length as m-dash]C(R)-O-], R = CH3 (), (t)Bu (), Ph (), o-tolyl (), p-tolyl (), p-OMePh ()), respectively. reacted with benzyl alcohol to generate the corresponding LAl(OBn)2 complex . Complexes and were characterized by (1)H and (13)C NMR spectroscopy, elemental analyses and single crystal X-ray diffraction analyses.

[The effects of DR2 on myocardial ischemic postconditioning and its underlying mechanisms].

Objective: To study the effects of dopamin receptors-2 (DR2) on myocardial ischemic postconditioning and explore its underlying mechanisms.

Methods: The myocardial ischemic postconditioning (PC) model was established in cultured primary rat neonatal cardiomyocytes which were then randomly assigned in the following groups: Nomial control group, Isehemia/reperfusion (L'R) group, PC (ischemic postconditioning) group, PC + Bro (Bromocriptine, a DB2 antagonist) group, PC + Hal (Haloperidol, a DB2 repressor) and PC + Hal + Bro groups. The lactate dehydrogenase (LDH) and superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in cell medium were analyzed by colorunetry.

A three-dimensional cadmium(II) coordination polymer: poly[[[μ-4,4'-(propane-1,3-diyl)dipyridine-κ(2)N:N](μ-3,3'-thiodipropionato-κ(3)O,O':O)cadmium(II)] monohydrate].

In the title coordination polymer, {[Cd(C6H8O4S)(C13H14N2)]·H2O}n, the Cd(II) atom displays a distorted octahedral coordination, formed by three carboxylate O atoms and one S atom from three different 3,3'-thiodipropionate ligands, and two N atoms from two different 4,4'-(propane-1,3-diyl)dipyridine ligands. The Cd(II) centres are bridged through carboxylate O atoms of 3,3'-thiodipropionate ligands and through N atoms of 4,4'-(propane-1,3-diyl)dipyridine ligands to form two different one-dimensional chains, which intersect to form a two-dimensional layer. These two-dimensional layers are linked by S atoms of 3,3'-thiodipropionate ligands from adjacent layers to form a three-dimensional network.

[17 cases of mucosal antral cyst with main symptoms of eye pain].

Objective: To draw the attention to mucosal antral cyst, thus reduce the probability of missed diagnosis and missed treatment by retrospectively analyzing 17 cases of eye pain patients with no obvious nasal symptoms in our department from January 2003 to September 2011.

Method: All patients were performed ophthalmologic examination including eye position, eyesight, refraction, visual field, intraocular pressure and fundus examination, and the results showed that all of them had no eye disease. After excluding the deviation of nasal septum, concha bullosa and Haller gas room, CT scanning of paranasal sinus showed the maxillary sinus cyst.

Poly[μ₇-sulfanediyldiacetato-disilver(I)].

In the title coordination polymer, [Ag₂(C₄H₄O₄S)], each AgI cation is four-coordinated by three of the four carboxylate O atoms and the S atom from symmetry-related sulfanediyldiacetate ligands, thus defining a distorted tetrahedral geometry at the metal centre. The AgI cations are bridged by sulfanediyldiacetate groups, leading to a two-dimensional layer structure. These layers are interconnected via Ag-S bonds to form a three-dimensional coordination polymer network overall.

Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels.

Maize kernel oil is a valuable source of nutrition. Here we extensively examine the genetic architecture of maize oil biosynthesis in a genome-wide association study using 1.03 million SNPs characterized in 368 maize inbred lines, including 'high-oil' lines.

A transposable element insertion within ZmGE2 gene is associated with increase in embryo to endosperm ratio in maize.

Most of the maize kernel oil is located in the embryo while the majority of starch is located in the endosperm. Maize kernel composition and value are affected significantly by the ratio of the embryo size to the endosperm size; however, the genetic regulation of embryo to endosperm ratio (EER) in maize is unknown. Here we identified ZmGE2 gene, which encodes a cytochrome p450 protein, as a gene associated with EER variation in maize.

[Analysis on effect of endoscopic nasal cavity surgery expansion in 108 cases].

Objective: To investigate the efficacy of endoscopic nasal cavity enlarging surgery for the alleviation of nasal obstruction.

Methods: One hundred and eight patients with deviation of the nasal septum (DNS) and chronic hypertrophic rhinitis (CHR) were included in this study. Individualized operations were performed.

Chitosan enhanced gene delivery of cationic liposome via non-covalent conjugation.

Two new types of stable ternary complexes were formed by mixing chitosan with DOTAP/pDNA lipoplex and DOTAP with chitosan/pDNA polyplex via non-covalent conjugation for the efficient delivery of plasmid DNA. They were characterized by atomic force microscopy, gel retarding, and dynamic light scattering. The DOTAP/CTS/pDNA complexes were in compacted spheroids and irregular lump of larger aggregates in structure, while the short rod- and toroid-like and donut shapes were found in CTS/DOTAP/pDNA complexes.

Quantitative modeling and optimization of magnetic tweezers.

Magnetic tweezers are a powerful tool to manipulate single DNA or RNA molecules and to study nucleic acid-protein interactions in real time. Here, we have modeled the magnetic fields of permanent magnets in magnetic tweezers and computed the forces exerted on superparamagnetic beads from first principles. For simple, symmetric geometries the magnetic fields can be calculated semianalytically using the Biot-Savart law.

Erratum: Poly[aqua-(μ(2)-oxalato)(4-oxidopyri-din-ium)erbium(II)]. Corrigendum.

The chemical name in the title, the formula and the scheme of the paper by Gu, Hao, Song, Lin & Ma [Acta Cryst. (2008), E64, m649-m650] are corrected.[This corrects the article DOI: 10.

Tetra-aqua-(1,10-phenanthroline-κN,N')magnesium(II) bis-[(2,4-dichloro-phen-yl)acetate].

In the mononuclear title complex, [Mg(C(12)H(8)N(2))(H(2)O)(4)](C(8)H(5)Cl(2)O(2))(2), each Mg(II) ion is hexa-coordinated by two N atoms from a 1,10-phenanthroline ligand [Mg-N = 2.233 (2) Å] and four water mol-ecules [Mg-OW = 2.033 (2) and 2.

μ-Aqua-κO:O-di-μ-4-methyl-benzoato-κO:O'-bis-[(4-methyl-benzoato-κO)(1,10-phenanthroline-κN,N')nickel(II)].

In the title dinuclear complex, [Ni(2)(C(8)H(7)O(2))(4)(C(12)H(8)N(2))(2)(H(2)O)], each Ni(II) atom is six-coordinated by three carboxylate O atoms from three 4-methyl-benzoate ligands, two N atoms from two 1,10-phenanthroline ligands, and one μ(2)-bridging aqua ligand. The dimeric complex is located on a crystallographic twofold axis and each Ni atom displays a distorted octa-hedral coordination geometry. The crystal structure is stabilized via intra-molecular hydrogen bonding of the bridging water mol-ecule and the uncoordinated carboxyl-ate O atoms, and by C-H⋯O and π-π stacking inter-actions [centroid-centroid distances between neighbouring phenanthroline ring systems and between the benzene ring of a 4-methyl-benzoate unit and a phenanthroline ring system are 3.

Diaqua-bis[2-(benzyl-oxy)acetato]cobalt(II).

In the mononuclear title complex, [Co(C(9)H(9)O(3))(2)(H(2)O)(2)], each Co(II) atom is located on an inversion center and is hexa-coordinated by four O atoms from two benzyl-oxyacetate ligands [Co-O bond lengths = 2.0487 (9) and 2.1090 (9) Å] and two water mol-ecules [Co-O bond length = 2.

Diaqua-bis(benzyl-oxyacetato)copper(II).

In the title mononuclear complex, [Cu(C(9)H(9)O(3))(2)(H(2)O)(2)], the Cu(II) ion, located on an inversion center, is hexa-coordinated by four O atoms from two benzyl-oxyacetate ligands [Cu-O = 1.9420 (14) and 2.2922 (14) Å] and two water mol-ecules [Cu-O = 2.