Post-marketing safety of finerenone: a disproportionality analysis of the FDA adverse event reporting system.

Background: Finerenone was approved for the treatment of type 2 diabetes patients with chronic kidney disease. However, the post-marketing safety of finerenone in the real world is unknown.

Methods: The quarterly reported data related to finerenone from the third quarter of 2021 to the second quarter of 2023 were collected by using the FAERS database.

Research progress on desensitization of hypersensitivity reaction to iodinated contrast media.

Desensitization therapy for iodinated contrast media (ICM) aims to induce drug tolerance in patients with a history of severe allergic reactions to ICM in a short time. Currently, there is no widely accepted consensus on inducing desensitization to avoid severe allergic responses to ICM. The clinically successful cases have shown that prophylactic use of antihistamines and glucocorticoids can increase the desensitization effect; repeatedly desensitizing and gradually increasing the dose can be conducive to establishing better tolerance to ICM.

Thyroid function analysis after roxadustat or erythropoietin treatment in patients with renal anemia: a cohort study.

Purpose: This cohort study was designed to explore whether roxadustat or erythropoietin could affect thyroid function in patients with renal anemia.

Methods: The study involved 110 patients with renal anemia. Thyroid profile and baseline investigations were carried out for each patient.

Circulating PCSK9 relates to aggravated disease activity, Th17/Treg imbalance, and predicts treatment outcome of conventional synthetic DMARDs in rheumatoid arthritis patients.

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates inflammatory response and CD4 T cell differentiation in autoimmune diseases, while its clinical role in rheumatoid arthritis (RA) lacks sufficient evidence. Subsequently, this study intended to explore the vertical change of PCSK9, and its linkage with T helper (Th) cells, regulatory T (Treg) cells, clinical features, and treatment outcomes in RA patients.

Methods: This multi-center, prospective, cohort study determined serum PCSK9 in 89 RA patients who received conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and 50 healthy controls (HCs) after recruitment by enzyme-linked immunosorbent assay.

Multiple Diagnostic Indicators in the Development of Chronic Hepatitis B, Liver Cirrhosis, and Liver Cancer.

Context: Hepatitis B can develop into cirrhosis, and most liver cancers evolve on the basis of chronic hepatitis and cirrhosis. Many patients are already at an advanced stage when diagnosed. In recent years, clinicians have advocated detection of liver cancer using multiple markers in combination to improve the sensitivity and specificity of testing.

Multivariate Time Series Imputation: An Approach Based on Dictionary Learning.

The problem addressed by dictionary learning (DL) is the representation of data as a sparse linear combination of columns of a matrix called dictionary. Both the dictionary and the sparse representations are learned from the data. We show how DL can be employed in the imputation of multivariate time series.

Clinical evaluation of contrast-enhanced CT combined with PET/CT in diagnosis of mediastinal lymph node metastasis of non-small-cell lung cancer.

Objectives: To investigate the clinical value of contrast-enhanced CT combined with PET/CT in the differential diagnosis of mediastinal lymph node metastasis (MLNM) of non-small-cell lung cancer (NSCLC).

Methods: A total of 120 patients with NSCLC combined with mediastinal lymphadenopathy hospitalized in our hospital were selected. All the patients received radical resection of lung cancer and mediastinal lymphadenectomy.

Performance Evaluation of Tunnel-Slag-Improved High Liquid Limit Soil in Subgrade: A Case Study.

The application of tunnel-slag-improved high liquid limit soil as filling materials in subgrade is a green environmental technology. This study explored the influence of tunnel slag mixing on the physical and mechanical properties of improved soils, based on the engineering background of Liyu highway, Guangxi Province, China. Firstly, the optimal moisture content, maximum dry density, shear strength parameters, California bearing ratio (CBR) and resilience modulus of plain and tunnel-slag-improved high liquid limit soils were experimentally determined.

Tunnel Squeezing Deformation Control and the Use of Yielding Elements in Shotcrete Linings: A Review.

Shotcrete lining shows high resistance but extremely low deformability. The utilization of yielding elements in shotcrete lining, which leads to the so-called ductile lining, provides a good solution to cope with tunnel squeezing deformations. Although ductile lining exhibits great advantages regarding tunnel squeezing deformation control, little information has been comprehensively and systematically available for its mechanism and design.

Construction of nitrogen vacant g-CN nanosheet supported AgPO nanoparticle Z-scheme photocatalyst for improved visible-light photocatalytic activity.

The superior photocatalytic activity of semiconductor-based photocatalytic materials has attracted great attention. In this work, a series of novel AgPO/g-CN (APO/CNx) composites with the Z-scheme structure were fabricated through a facile precipitation method. B naphthol, a typical phenolic compound, was selected to evaluate the photocatalytic activity of all as-prepared photocatalysts.

Influence of aging on chronic unpredictable mild stress-induced depression-like behavior in male C57BL/6J mice.

Depression is a common psychiatric disorder that can occur throughout an individual's lifespan. Chronic unpredictable mild stress (CUMS) protocol is currently the most commonly used to develop an animal model of depression. Due to the variable duration and procedure of CUMS, it is difficult to reproduce and explore the mechanism of CUMS-induced depression effectively.

Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice.

Slit2 is a member of the Slit family of secreted glycoproteins that plays highly conserved roles in neuronal axon guidance and cellular migration. Our previous experimental results showed Alzheimer's disease-like alterations and increased permeability of the blood-brain barrier in Slit2-overexpressing transgenic (Slit2-Tg) mice aged 8-9 months. Nevertheless, relatively little is known about behavioral alterations in adult Slit2-Tg mice (2-6 months of age).

Preliminary Research on Response of GCr15 Bearing Steel under Cyclic Compression.

During the bearing service, a series of microstructural evolutions will arise inside the material, such as the appearance of feature microstructures. The essential reason for the microstructural evolution is the cumulative effect of cyclic stress. The Hertz Contact formula is usually adopted to calculate the internal stress, and there is a correlation between the shape and distribution of the feature microstructure and the stress distribution.

Fibroblast Growth Factor 2 Attenuates Renal Ischemia-Reperfusion Injury via Inhibition of Endoplasmic Reticulum Stress.

Acute kidney injury (AKI) is a serious clinical disease that is mainly caused by renal ischemia-reperfusion (I/R) injury, sepsis, and nephrotoxic drugs. The pathologic mechanism of AKI is very complex and may involve oxidative stress, inflammatory response, autophagy, apoptosis, and endoplasmic reticulum (ER) stress. The basic fibroblast growth factor (FGF2) is a canonic member of the FGF family that plays a crucial role in various cellular processes, including organ development, wound healing, and tissue regeneration.

Differences between generalized Q-sampling imaging and diffusion tensor imaging in visualization of crossing neural fibers in the brain.

Purpose: The aim of this study was to discuss the advantages of GQI reconstruction in the imaging of nerve fibers at crossing regions. Compared with DTI, the paper also discussed the advantages of GQI in imaging principles.

Methods: 3-T MRI data from five normal participants were reconstructed using GQI and DTI.

Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling.

Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders.

Retinoic Acid Prevents Disruption of Blood-Spinal Cord Barrier by Inducing Autophagic Flux After Spinal Cord Injury.

Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB), which leads to infiltration of blood cells, inflammatory responses and neuronal cell death, with subsequent development of spinal cord secondary damage. Recent reports pointed to an important role of retinoic acid (RA), the active metabolite of the vitamin A, in the induction of the blood-brain barrier (BBB) during human and mouse development, however, it is unknown whether RA plays a role in maintaining BSCB integrity under the pathological conditions such as SCI. In this study, we investigated the BSCB protective role of RA both in vivo and in vitro and demonstrated that autophagy are involved in the BSCB protective effect of RA.