Relationship of corneal percent tissue altered with visual outcome in small incision lenticule extraction surgery.

Background: We observed the effect of different modified percentage of tissue alteration (mPTA) on corneal higher-order aberrations in small incision lenticule extraction (SMILE), and explored safe threshold values of mPTA for SMILE surgery.

Methods: 148 patients (270 eyes) was retrospectively analyzed and grouped into two groups based on mPTA between 24%. Mixed linear model analysis was used for preoperative and postoperative 1 week (W1), 1 month (M1), 3 months (M3), and 6 months (M6) follow-ups to compare the differences and changes in visual acuity, and corneal higher order aberrations between groups.

Network analysis of Internet addiction and depression among Chinese adolescents.

Background: Internet addiction (IA) and depression are common mental health concerns, with burgeoning empirical evidence highlighting their significant comorbid relationship among adolescents. We aimed to establish network structures for IA and depression among Chinese adolescents, and to identify the core and bridge symptoms.

Methods: A total of 8176 participants were recruited from Henan Province, Central China.

Antagonistic effects of endophytic fungi from pedicels on yeasts: implications for antimicrobial mechanism of nectar.

Endophytic fungi are extensive in plant tissues and involved in the defense against stress from harmful microbes. The interaction between pedicel endophytic fungi and nectar yeasts is critical for maintaining nectar homeostasis. This study used as the research subject.

Association Between Cognitive Function and Emotion, Sleep, Frailty, and Nutrition in Hospitalized Patients.

Background: With the rapid increase in China's aging population, cognitive impairment in the elderly has become a significant public health issue.

Aims: In this study we performed a cross-sectional analysis to comprehensively investigate the relationship between cognitive function and emotion, sleep, frailty, nutrition, and clinical variables in hospitalized geriatric patients according to age group and sex. We determined the most important risk factors for cognitive impairment.

Endophytic bacteria in pedicels: isolation, screening and analysis of antagonistic activity against nectar yeasts.

, an ancient plant species endemic to Yunnan Province, China, remains underexplored in terms of its endophytic bacterial communities. The plant tissue pedicel serves as the connection between the flower and the stem, not only delivers nutrients but also transmits metabolic substances from endophytic bacteria to the nectar during long-term microbial colonization and probably improves the antagonistic activity of nectar against yeast. Hence, 138 isolates of endophytic bacteria have been isolated in this study from the pedicels of 12- and 60-year-old .

Mediation Effect of Obesity on the Association of Socioeconomic Status with Blood Pressure in the Elderly Hypertensive Population.

Background: Socioeconomic status (SES) plays a crucial role in blood pressure (BP) control. SES may influence BP control through obesity indices, such as body mass index (BMI) and waist circumference (WC). This study aimed to understand the relationships between SES and BP control in the elderly hypertensive population, and to determine whether BMI and WC mediate the relationship between SES and BP control.

Cardioprotective role of oleanolic acid in patients with type 2 diabetes mellitus.

Background: Patients with type 2 diabetes mellitus (T2DM) experience a decline in cardiac function, resulting in poor prognosis. Therefore, restoration of cardiac function and improvement of myocardial fibrosis is an important treatment goal for patients with T2DM.

Material And Methods: The chemical structure of oleanolic acid(OA) was downloaded from PubChem and uploaded to PharmMapper.

Temporal changes in factors associated with COVID-19 vaccine hesitancy among Chinese adults: Repeated nationally representative survey.

Background: COVID-19 vaccine hesitancy has been cited as one of the main obstacles impacting vaccine coverage. However, factors that affect hesitancy may change over time. Understanding these evolving concerns and adapting strategies accordingly are crucial for effectively addressing vaccine hesitancy effectively and promoting public health.

A peanut and weed detection model used in fields based on BEM-YOLOv7-tiny.

Due to the different weed characteristics in peanut fields at different weeding periods, there is an urgent need to study a general model of peanut and weed detection and identification applicable to different weeding periods in order to adapt to the development of mechanical intelligent weeding in fields. To this end, we propose a BEM-YOLOv7-tiny target detection model for peanuts and weeds identification and localization at different weeding periods to achieve mechanical intelligent weeding in peanut fields at different weeding periods. The ECA and MHSA modules were used to enhance the extraction of target features and the focus on predicted targets, respectively, the BiFPN module was used to enhance the feature transfer between network layers, and the SIoU loss function was used to increase the convergence speed and efficiency of model training and to improve the detection performance of the model in the field.

Ultrasound-based Radiomics for Predicting Metastasis in the Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in Patients with Papillary Thyroid Cancer.

Background: Dissection of the lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLNs) in papillary thyroid cancer (PTC) remains controversial.

Objective: This study aimed to determine the capability of ultrasonography (US)-based radiomics for presurgical prediction of metastasis in LN-prRLNs in PTC.

Methods: Patients were retrospectively enrolled and pathologically confirmed as LN-prRLN metastasis with PTC after surgery.

Construction and analysis of evaluation model for medical students' innovation competency based on research-oriented biochemistry and molecular biology course in China.

Presently, a variety of policies and measures has implemented to enhance the scientific research and innovation ability of medical students, but in the process of practice, there are many problems, such as they lack of independent topic selection ability, weak scientific research skills, lack of autonomous learning ability, the research results are simple and ineffective, limited teacher guidance time and so on. This paper attempted to build an effective model for the promotion of medical students' scientific research and innovation ability, in order to establish an efficacy evaluation model of the "Medical students' Innovative Scientific Research Program." Undergraduates, graduate assistants, and tutors were interviewed with the Behavioral Event Interview technique, and a questionnaire of efficacy evaluation characteristics concluded from the interviews was formed.

Evaluation of a questionnaire as a screening tool for benign paroxysmal position vertigo.

Objective: To determine the value of a questionnaire as a screening tool for benign paroxysmal position vertigo (BPPV).

Study Design: Retrospective chart review.

Setting: Tertiary care centers.

Efficacy Comparison of Repeated Low-Level Red Light and Low-Dose Atropine for Myopia Control: A Randomized Controlled Trial.

Purpose: To compare the treatment efficacy between repeated low-level red light (RLRL) therapy and 0.01% atropine eye drops for myopia control.

Methods: A single-masked, single-center, randomized controlled trial was conducted on children 7 to 15 years old with cycloplegic spherical equivalent refraction (SER) ≤ -1.

Predictive value of serum interleukin-6 to determine surgical drainage of deep neck space infection in adults.

Purpose: The aim of this study was to determine whether interleukin-6 (IL-6) could be used as a predictor for surgical drainage in deep neck space infection (DNSI).

Methods: A retrospective study was conducted to analyze 69 adult patients newly diagnosed as DNSI from January 2017 to December 2021 at a single center. The patients were treated with either surgical drainage or not.

Clinical characteristics of subjective idiopathic tinnitus and preliminarily analyses for the effect of tinnitus multielement integration sound therapy.

Objective: To study the psychoacoustic and audiological characteristics of patients with chronic subjective tinnitus and provide basis for the personalized diagnosis and treatment of tinnitus through a single tinnitus multielement integration sound therapy (T-MIST) and analysis of efficacy preliminarily.

Methods: 145 patients with tinnitus were assessed by systematic medical history collection, professional examination of otolaryngology, audiology examination, full precision test (FPT), residual inhibition test (RIT), tinnitus handicap inventory (THI) and visual analog scale (VAS) annoyance. The correlation among factors was performed.

IRE1α-JNK pathway-mediated autophagy promotes cell survival in response to endoplasmic reticulum stress during the initial phase of hepatic steatosis.

Aims: It has been widely reported that autophagy and inositol-requiring enzyme-1α (IRE1α)-c-Jun N-terminal kinase (JNK) pathway was involved in cell survival under endoplasmic reticulum (ER) stress, but their specific roles in hepatic steatosis remain unclear. This study aimed to determine the interaction between autophagy and IRE1α-JNK pathway on cell survival in response to ER stress during the initial phase of hepatic steatosis.

Methods: Hepatic steatosis was induced in HepG2 cells by supplementing oleic acid (OA).

Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel.

Background And Purpose: The cytokine activin C is mainly expressed in small-diameter dorsal root ganglion (DRG) neurons and suppresses inflammatory pain. However, the effects of activin C in neuropathic pain remain elusive.

Experimental Approach: Male rats and wild-type and TRPV1 knockout mice with peripheral nerve injury - sciatic nerve axotomy and spinal nerve ligation in rats; chronic constriction injury (CCI) in mice - provided models of chronic neuropathic pain.

Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.

Background: Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis.

Methods: Published studies concerned association between IL12B rs10045431, rs6887695 polymorphisms and IBD were searched from the Wiley Online Library, PubMed, Web of Science and the CNKI database.

Ursodeoxycholic acid alleviates nonalcoholic fatty liver disease by inhibiting apoptosis and improving autophagy via activating AMPK.

Ursodeoxycholic acid (UDCA), first identified in bear bile, was widely used in cholestatic liver diseases. Our previous studies have suggested UDCA may exert favorable influence on hepatic steatosis. However, the molecular mechanism remains elusive.

Association of , , and Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis.

Background: Anti-inflammatory cytokine polymorphisms in the transforming growth factor-β1 (), interleukin-4 (), and genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations.

Methods: A systematic literature search of five databases was performed up to October 2019.

An ultra-sensitive "turn-off" fluorescent sensor for the trace detection of rifampicin based on glutathione-stabilized copper nanoclusters.

Rifampicin is a common antibiotic used in human and veterinary medicine to treat tuberculosis and other diseases caused by numerous pathogenic bacteria. However, the excessive or improper use of rifampicin usually leads to a series of problems, including bacterial resistance, excessive drug-resistance and water pollution. Thus, it is of great importance to develop selective and sensitive assays for monitoring rifampicin in biological systems.

Label-free detection of folic acid using a sensitive fluorescent probe based on ovalbumin stabilized copper nanoclusters.

In this work, ovalbumin (OVA) stabilized copper nanoclusters (OVA-Cu NCs) were prepared through a simple protein-stabilized synthetic method and applied for the sensitive determination of FA. Cu ions were directly reduced to Cu (0) by a mild reducing agent, NH·HO, at room temperature without any other complicated procedure such as adjusting pH and controlling the temperature of the reaction mixture. The as-prepared OVA-Cu NCs showed good chemical stability, wonderful water solubility and excellent biocompatibility.

Facile synthesis of near-infrared emitting dBSA-templated Cu nanoclusters for sensitive detection of heparin.

Heparin is the most widely studied glycosaminoglycan. It plays an important role in regulating several normal physiological and pathological processes, including inhibition of thrombocytopenia, lipid regulation, metabolism and electrostatic attraction with various proteins. Hence, it is crucial to develop selective and sensitive assays for monitoring heparin levels in biological systems.