Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage.

Background: The island sign is a predictor of hematoma expansion and worse outcomes in patients of spontaneous primary intracerebral hemorrhage (ICH). The biological mechanism of the island sign remains unclear, but its presence might be influenced by the underlying vasculopathy related to Apolipoprotein E () genotypes. Therefore, we aimed to research the association between genotypes and the island sign.

RCM: A Neural Policy Model With Reconstruction Mechanism to Construct a Solution for the Agile Satellite Scheduling Problem.

The agile Earth observation satellite scheduling problem (AEOSSP) with time-dependent transition time is a combinatorial optimization challenge. Due to its NP-hardness, problem-tailored methods are sensitive to instances and require massive computational overhead. Recently, deep reinforcement learning (DRL) models have shown promise in efficiently addressing the AEOSSP.

Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

Importance: Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).

Objective: To evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.

Design, Setting, And Participants: This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, in 11 centers in China, with a 180-day follow-up.

Emerging MOFs, COFs, and their derivatives for energy and environmental applications.

Traditional fossil fuels significantly contribute to energy supply, economic development, and advancements in science and technology. However, prolonged and extensive use of fossil fuels has resulted in increasingly severe environmental pollution. Consequently, it is imperative to develop new, clean, and pollution-free energy sources with high energy density and versatility as substitutes for conventional fossil fuels, although this remains a considerable challenge.

Hydrogel microspheres immobilized lipase inspired by golf ball surfaces for the deacidification of Antarctic krill oil.

Lipase-catalyzed esterification for enhancing oil quality has garnered extensive attention due to its eco-friendly and efficient merits. Nevertheless, during the catalytic esterification process at the oil-water interface to reduce acid value, the immobilized lipase is prone to detachment as a result of continuous mechanical agitation. In this study, inspired by the aerodynamic theory of golf ball surfaces, a novel immobilized enzyme system is designed and fabricated to improve the quality of Antarctic krill oil and prolong its storage time.

Analysis of the antioxidant efficacy substances in fermented black mulberry juice and their preventive effects on oxidative stress in C2C12 cells.

This study evaluated the in vitro antioxidant activity and bioactive compound content of mixed-strain lactic acid bacteria-fermented black mulberry juice (FBMJ) and its protective effects against oxidative stress using physicochemical experiments and a cellular oxidative stress model. We also performed preliminary analyses of polysaccharide structures in FBMJ and identified the dynamic changes in the phenolic profiles of FBMJ during the fermentation process. The results indicated that FBMJ polyphenols can improve cell vitality and prevent HO-induced oxidative stress by reducing intracellular reactive oxygen species concentrations and regulating mitochondrial membrane potential.

Subarachnoid hemorrhage and finger-like projection predict recurrence in patients with lobar intracerebral hemorrhage.

Background And Purpose: Lobar intracerebral hemorrhage (ICH) is associated with a high risk of recurrence, particularly in elderly patients, where cerebral amyloid angiopathy (CAA) is often the primary cause. Diagnostic markers of CAA-related ICH, including subarachnoid hemorrhage (SAH) and finger-like projection (FLP), have recently been developed. Here, we aimed to explore the associations between SAH, FLP and the risk of ICH recurrence in lobar ICH patients.

Modulating the Coordination Environment of Atomically Dispersed Nickel for Efficient Electrocatalytic CO Reduction at Low Overpotentials and Industrial Current Densities.

Electrocatalytic CO-to-CO conversion with a high CO Faradaic efficiency (FE) at low overpotentials and industrial-level current densities is highly desirable but a huge challenge over non-noble metal catalysts. Herein, graphitic N-rich porous carbons supporting atomically dispersed nickel (NiN-O sites with an axial oxygen) were synthesized (denoted as O-Ni-N-GC) and applied as the cathode catalyst in a CORR flow cell. O-Ni-N-GC showed excellent selectivity with a FE over 92% at low overpotentials ranging from 17 to 60 mV, and over 99% at 80 mV.

Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights.

Recent studies have unveiled the deep sea as a rich biosphere, populated by species descended from shallow-water ancestors post-mass extinctions. Research on genomic evolution and microbial symbiosis has shed light on how these species thrive in extreme deep-sea conditions. However, early adaptation stages, particularly the roles of conserved genes and symbiotic microbes, remain inadequately understood.

Association of genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage.

Background And Objective: We investigated the association of alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).

Methods: We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of with ICH location (lobar vs non-lobar) was evaluated.

Examining the effectiveness of motor imagery combined with non-invasive brain stimulation for upper limb recovery in stroke patients: a systematic review and meta-analysis of randomized clinical trials.

Background: Transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) are common non-invasive brain stimulation (NIBS) methods for functional recovery after stroke. Motor imagery (MI) can be used in the rehabilitation of limb motor function after stroke, but its effectiveness remains to be rigorously established. Furthermore, there is a growing interest in the combined application of NIBS with MI, yet the evidence regarding its impact on the recovery of upper limb function after stroke is inconclusive.

Piezocatalytic techniques and materials for degradation of organic pollutants from aqueous solution.

With the rapid development of industry, agriculture, and urbanization, various organic pollutants have accumulated in natural water, posing a potential threat to both the ecological environment and human beings, and removing organic pollutants from water is an urgent priority. Piezoelectric techniques, with the advantages of green, simple operation, and high efficiency, are highly sought after in the degradation of environmental organic pollutants. Moreover, combining piezoelectric techniques with advanced oxidation processes (AOPs), photocatalysis, or electrocatalysis can further effectively promote the efficient degradation of target pollutants.

Rapid Antimicrobial Susceptibility Test of Helicobacter pylori to Metronidazole via Single-Cell Raman Spectrometry.

Background: Metronidazole is a first-line antibiotic to treat Helicobacter pylori infections. However, the Clinical Laboratory Standards Institute guidelines recommend against using antimicrobial susceptibility test (AST) to test metronidazole resistance, due to the unreliable predictive power which can result in treatment failure.

Objectives: The aim of this study was to establish an 8-h, metabolic-phenotype based AST for H.

Secondary metal ion-induced electrochemical reduction of U(VI) to U(IV) solids.

Recent studies have shown that aqueous U(VI) ions can be transformed into U(VI) precipitates through electrocatalytic redox reactions for uranium recovery. However, there have been no reports of U(IV) solids, such as UO, using electrochemical methods under ambient conditions since low-valence states of uranium are typically oxidized to U(VI) by O or HO. Here we developed a secondary metal ion-induced strategy for electrocatalytic production of U(IV) solids from U(VI) solutions using a catalyst consisting of atomically dispersed gallium on hollow nitrogen-doped carbon capsules (Ga-N-C).

Single-Molecule Traps in Covalent Organic Frameworks for Selective Capture of CH from CH-Rich Gas Mixtures.

Removing trace amounts of acetylene (CH) from ethylene (CH)-rich gas mixtures is vital for the supply of high-purity CH to the chemical industry and plastics sector. However, selective removal of CH is challenging due to the similar physical and chemical properties of CH and CH. Here, we report a "single-molecule trap" strategy that utilizes electrostatic interactions between the one-dimensional (1D) channel of a covalent organic framework (denoted as COF-1) and CH molecules to massively enhance the adsorption selectivity toward CH over CH.

Integrating automated machine learning and metabolic reprogramming for the identification of microplastic in soil: A case study on soybean.

The accumulation of polyethylene microplastic (PE-MPs) in soil can significantly impact plant quality and yield, as well as affect human health and food chain cycles. Therefore, developing rapid and effective detection methods is crucial. In this study, traditional machine learning (ML) and H2O automated machine learning (H2O AutoML) were utilized to offer a powerful framework for detecting PE-MPs (0.

The positive impact of introducing public engagement as a self-directed learning strategy in undergraduate nervous system education.

Undergraduate medical education in China has shifted from educator-centered learning to self-directed learning (SDL) over the past few decades. Careful design of public engagement activities can enable SDL and empower medical students to pioneer public health and patient safety education. In this study, we aimed to innovate nervous system education by implementing a public engagement model that empowers students to learn about the nervous system by teaching the public.

Dietary Chitosan Attenuates High-Fat Diet-Induced Oxidative Stress, Apoptosis, and Inflammation in Nile Tilapia () through Regulation of Nrf2/Kaep1 and Bcl-2/Bax Pathways.

Fatty liver injury is a prevalent condition in most farmed fish, yet the molecular mechanisms underpinning this pathology remain largely elusive. A comprehensive feeding trial spanning eight weeks was conducted to discern the potential of dietary chitosan in mitigating the deleterious effects of a high-fat diet (HFD) while concurrently exploring the underlying mechanism. Growth performance, haemato-biochemical capacity, antioxidant capacity, apoptotic/anti-apoptotic gene expression, inflammatory gene expression, and histopathological changes in the liver, kidney, and intestine were meticulously assessed in Nile tilapia.

Palladium(II) Modulation Enhances the Water Stability and Aqueous TcO/ReO Removal Performance of Metal-Organic Frameworks.

Improving the water stability of metal-organic frameworks (MOFs) is essential for their use in water pollution treatment and environmental remediation, though it remains technically challenging. Herein, we report a novel cationic MOF constructed with [ThO(OH)(COO)] units and [CoN·Cl] units possessing a ftw-type topology (denoted as ). itself exhibited poor water stability but excellent stability following a palladium(II) modulation strategy.

The application of innovative ecosystems to build resilient communities in response to major public health events.

In recent years, major public health events have had a significant and far-reaching impact on communities. As a response, there has been an increasing interest in enhancing community resilience through innovative ecosystems that involve diverse stakeholders with varying needs and demands. This study investigates the application of innovative ecosystems to improve community resilience in the face of major public health events by utilizing a sequential game approach to balance the interests of government, community, and residents.

Theoretical Study of the Ternary Compound Monolayer CuPSe for Photocatalytic Water Splitting with Efficient Optical Absorption.

Utilizing photocatalytic method to produce hydrogen by splitting water is an efficient strategy to solve the hotspot issues of energy crisis and environmental pollution. Herein, we systematically investigate the corresponding properties of the reported Cu-bearing ternary compound monolayer CuPSe by using the first-principle calculations. The monolayer CuPSe has quite small cleavage energy of 0.

Engineering the pore environment of antiparallel stacked covalent organic frameworks for capture of iodine pollutants.

Radioiodine capture from nuclear fuel waste and contaminated water sources is of enormous environmental importance, but remains technically challenging. Herein, we demonstrate robust covalent organic frameworks (COFs) with antiparallel stacked structures, excellent radiation resistance, and high binding affinities toward I, CHI, and I under various conditions. A neutral framework (ACOF-1) achieves a high affinity through the cooperative functions of pyridine-N and hydrazine groups from antiparallel stacking layers, resulting in a high capacity of ~2.