Dynamics of the immune microenvironment and immune cell PANoptosis in colorectal cancer: recent advances and insights.

Colorectal cancer (CRC) is one of the most significant oncological threats to human health globally. Patients often exhibit a high propensity for tumor recurrence and metastasis post-surgery, resulting in suboptimal prognoses. One of the underlying reasons for the metastatic potential of CRC is the sustained abnormal state of the tumor immune microenvironment, particularly characterized by the atypical death of critical immune cells.

Unraveling the immunogenetic landscape of autism spectrum disorder: a comprehensive bioinformatics approach.

Background: Autism spectrum disorder (ASD) is a disease characterized by social disorder. Recently, the population affected by ASD has gradually increased around the world. There are great difficulties in diagnosis and treatment at present.

Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method.

Background: Senescence have emerged as potential factors of lung cancer risk based on findings from many studies. However, the underlying pathogenesis of lung cancer caused by senescence is not clear. In this study, we try to explain the potential pathogenesis between senescence and lung cancer through proteomics and metabonomics.

Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study.

Background: Observational studies have reported a strong association between autistic spectrum disorder (ASD) and intestinal metabolites. However, it is unclear whether this correlation is causally or violated by confounding or backward causality. Therefore, this study explored the potential causal relationship between intestinal metabolites and dependent metabolites on ASD.

Efficient removal of perfluorinated compounds from water using a regenerable magnetic activated carbon.

Adsorption by powder activated carbon (PAC) is recognized as an efficient method for the removal of perfluorinated compounds (PFCs) in water, while the poor separation of spent PAC makes it difficult for further regeneration, increasing the treatment cost significantly. In this study, an ultrafine magnetic activated carbon (MAC) consisting of FeO and PAC was prepared by ball milling to remove PFCs from water efficiently. Increasing the percentage of FeO and balling milling time decreased its adsorption capacity for perfluoroctane sulfonate (PFOS), whereas increased the magnetic separation property to some degree.

TLR3 regulates PD-L1 expression in human cytomegalovirus infected glioblastoma.

Glioblastoma, the most common primary brain tumor of adults, is characterized by poor survival rates. Programmed death ligand 1 (PD-L1, CD274) has been implicated in the immune escape of glioblastoma. The presence of human cytomegalovirus (HCMV) in glioblastoma multiforme (GBM) has sparked considerable interest and controversy.