Understanding the Key Role of Cations in Water Tolerance during the CO/CO Separation Process under Low-Humidity Conditions.

The efficient separation of CO and CO under low-humidity conditions is crucial for ensuring the long-term operational stability of industrial applications. While the number of adsorbent cations plays a key role in separation, their influence on purification under low humidity remains insufficiently understood. The breakthrough results indicate that, even under extremely low humidity, the adsorption capacity of CO and CO can decrease by up to 6 and 24%, respectively.

Analysis of trends in cancer mortality and the years of life lost in six provinces in northwest China from 2013 to 2021.

Cancer is a major cause of death and morbidity in China. We aimed to analyze the trends in cancer mortality in six provinces in northwest China (Xinjiang Uyghur Autonomous Region, Qinghai Province, Shaanxi Province, Gansu Province, Ningxia Hui Autonomous Region, and Inner Mongolia Autonomous Region) from 2013 to 2021 and to explore the effect of cancer on life expectancy and the years of life lost. Based on cancer mortality data and demographic data from national surveillance units in six northwestern provinces from 2013 to 2021 in the National Cause-of-Death Surveillance, we calculated crude mortality rates, age-standardized mortality rates, life expectancy, cause-eliminated life expectancy, potential gains in life expectancy (PGLEs), years of life lost (YLL), YLL rates, and average years of life lost.

Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway.

Purpose: Doxorubicin (DOX), an anthracycline antibiotic, has limited clinical use due to its pronounced cardiotoxicity. Irisin, a myokine known for its metabolic regulation, has shown therapeutic effects on cardiovascular disease. This study investigates the potential cardioprotective function of irisin in reducing the cardiac injury induced by DOX.

Application of polydopamine as antibacterial and anti-inflammatory materials.

Polydopamine (PDA), as a material mimicking the adhesive proteins of mussels in nature, has emerged as a strong candidate for developing novel antibacterial and anti-inflammatory materials due to its outstanding biomimetic adhesion, effective photothermal conversion, excellent biocompatibility and antioxidant capabilities. This review discussed in detail the intricate structure and polymerization principles of PDA, elucidated its mechanisms in combating bacterial infections and inflammation, as well as explored the innovative use of PDA-based composite materials for antibacterial and anti-inflammatory applications. By providing an in-depth analysis of PDA's capabilities and future research directions, this review addresses a crucial need for safer, more effective, and controllable antimicrobial and anti-inflammatory strategies, which aim to contribute to the development of advanced materials that can significantly impact public health.

Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong.

Background: This study investigated the human papillomavirus (HPV) infection status among women in Zigong from January 2016 to August 2024 and provides a comprehensive statistical analysis of HPV infection characteristics. The findings aim to enhance cervical cancer screening, inform vaccination strategies, and improve HPV infection prevention measures.

Methods: We conducted a retrospective analysis on 48,474 female patients who visited the gynecology department of Zigong Fourth People's Hospital from January 2016 to August 2024.

Integrating Donor Derived Cell-Free DNA Fraction and Absolute Quantification for Enhanced Rejection Diagnosis in Kidney Transplant Recipients.

This study aimed to assess the diagnostic accuracy of combining donor-derived cell-free DNA (dd-cfDNA) fraction and absolute quantification in detecting kidney allograft rejection. A prospective study was conducted from December 2019 to April 2021 at the First Affiliated Hospital of Sun Yat-sen University. Kidney transplant recipients who underwent biopsy, including cases of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR), and borderline rejection, were included.

The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder.

Major depressive disorder (MDD) is a widespread and severe mental health condition characterized by persistent low mood and loss of interest. Emerging evidence suggests that ferroptosis, an iron-dependent form of cell death, and epigenetic dysregulation contribute to the pathogenesis of MDD. This study investigates the role of RNA demethylase FTO and autophagy regulator BECN1 in ferroptosis and their regulation by the active compound ginsenoside Rb1 (GRb1) as a potential antidepressant strategy.

Development of an enzymatic method for efficient production of DHA-enriched phospholipids through immobilized phospholipase A1 in AOT-water reverse micelles.

The demand for omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), has been steadily increasing due to their significant health benefits. Traditional methods for producing DHA-enriched phospholipids often suffer from low efficiency and high costs. In this study, we developed an efficient enzymatic process to prepare phospholipid-DHA, which used immobilized phospholipase A1 to catalyze transesterification in AOT-water reverse micelle systems.

Unintended consequences: China's pairing assistance policy and carbon emissions in administrative border areas -evidence from China.

The investigation of the unintended impact of pairing assistance policies on carbon emissions in administrative boundary regions is critical for achieving the "dual carbon" goals. This paper utilizes a sample of cities from the Pearl River Delta and the eastern and western regions of Guangdong, China, spanning from 2006 to 2020. A quasi-natural experiment based on the co-construction of industrial parks is employed to examine its impact on carbon emissions in boundary regions.

Endovascular Therapy is Effective in Patients with Post-Thrombotic Syndrome Based on Anatomical Classification: A Multi-Center Experience.

Background: In this study, we aimed to retrospectively review patients with post-thrombotic syndrome (PTS) and investigate its long-term outcomes, and a novel classification were presented across multiple institutions.

Methods: We retrospectively evaluated patients with PTS who underwent endovascular therapy at 2 institutions between January 2018 and September 2023. Baseline patient demographics, lesion characteristics, and in-hospital and follow-up outcomes were collected and analyzed retrospectively.

Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth.

Mitochondrial uncouplers dissipate proton gradients and deplete ATP production from oxidative phosphorylation (OXPHOS). While the growth of prostate cancer depends on OXPHOS-generated ATP, the oncogenic pathway mediated by the transcription factor E2F1 is crucial for the progression of this deadly disease. Here, we report that mitochondrial uncouplers, including tizoxanide (TIZ), the active metabolite of the Food and Drug Administration (FDA)-approved anthelmintic nitazoxanide (NTZ), inhibit E2F1-mediated expression of genes involved in cell cycle progression, DNA synthesis, and lipid synthesis.

Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis.

Background: Diabetes mellitus (DM) is the common comorbidity with lung cancer (LC), and metabolic disorders have been identified as significant contributors to the pathogenesis of both DM and LC. The causality between diabetes mellitus and lung cancer is still controversial. Hence, the causal effects of DM on the risk of LC was systemically investigated, and the mediating role of blood metabolites in this relationship was further explored.

Active Interfacial Perimeter in Pt/CeO Catalysts with Embedding Structure for Water-Tolerant Toluene Combustion.

Supported Pt catalysts are often subjected to severe deactivation under the conditions of high temperature and water vapor in catalytic oxidation; thus, the superior stability and water-resistant ability of catalysts have great significance for the effective degradation of volatile organic compounds (VOCs). Herein, we constructed a Pt/CeO-N catalyst with an active interfacial perimeter, in which Pt species were partially embedded in the defective CeO-N support to prevent the sintering. A significant charge transfer between Pt species and ceria in the embedding structure occurred via the Pt-CeO interface, which induced the formation of a Pt-O-Ce interfacial structure.

Automated Structural Bolt Micro Looseness Monitoring Method Using Deep Learning.

The detection of bolt loosening in key components of aircraft engines faces problems such as complex and difficult-to-establish bolt loosening mechanism models, difficulty in identifying early loosening, and difficulty in extracting signal features with nonlinear and non-stationary characteristics. Therefore, the automated structural bolt micro looseness monitoring method using deep learning was proposed. Specifically, the addition of batch normalization methods enables the established Batch Normalized Stacked Autoencoders (BNSAEs) model to converge quickly and effectively, making the model easy to build and effective.

Improvement of egg yolk powder properties through ultrasound coupled sodium sulfite pretreatment assisted enzymatic hydrolysis and underlying mechanism.

Egg yolk is an excellent protein source for the production of bioactive peptides. However, the recent method need to remove lipid first which involves wastage and pollution of organic reagents. Therefore, the process of directly using oily yolk powder to prepare egg yolk peptides has attracted much attention.

Rutin Ameliorates ALS Pathology by Reducing SOD1 Aggregation and Neuroinflammation in an SOD1-G93A Mouse Model.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons, with limited effective treatments. Recently, the exploration of natural products has unveiled their potential in exerting neuroprotective effects, offering a promising avenue for ALS therapy. In this study, the therapeutic effects of rutin, a natural flavonoid glycoside with neuroprotective properties, were evaluated in a superoxide dismutase 1 (SOD1)-G93A mouse model of ALS.

Targeted Delivery of AR-V7 siRNA with Bivalent PSMA Aptamers Effectively Suppresses the Growth of Enzalutamide-Resistant Prostate Cancer.

Androgen deprivation therapy has been the primary treatment strategy for advanced prostate cancer (PCa). But most patients develop castration resistance over time. For FDA-approved second-generation androgen receptor (AR) antagonists, including enzalutamide (ENZ) and abiraterone (AA), patients who initially respond to them eventually develop resistance.

Dye-sensitized NiO photocathode sensor based on signal-sensitive change strategy for MC-LR detection.

A novel photoelectrochemical (PEC) sensor for the detection of microcystic toxins (MC-LR) was developed on the basis of signal-sensitive change strategy. NiO nanoarray as a basic photoactive material was grown directly on the ITO glass electrode via calcination after hydrothermal reaction, while dye N719 was used to sensitize the electrode for enhancing visible light absorption, and the first signal-on stage was obtained. In the meantime, p-type CuO was applied as the signal probe attached to probe DNA (DNA) to improve the sensitivity, and the second "signal-on" stage appeared because of its synergistic effect with NiO nanoarrays.

Melatonin and copper oxide nanoparticles synergistically mitigate clubroot disease and enhance growth dynamics in Brassica rapa.

Clubroot, a devastating soil borne disease affecting 30%∼50% of Brassicaceae crops worldwide, lacks effective control measures. In the present study, we explored the potential of melatonin (MT) and copper oxide nanoparticle (CuO-NPs) in mitigating clubroot severity in the Brassica rapa ssp. pekinensis.

Association Between Particulate Matter Exposure and Preterm Birth in Women With Abnormal Preconception Thyrotropin Levels: Large Cohort Study.

Background: Prior research has linked exposure to particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5) with preterm birth (PTB).

Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration.

Background: Deoxyribonuclease 2 (DNase II) plays a key role in clearing cytoplasmic double-stranded DNA (dsDNA). Deficiency of DNase II leads to DNA accumulation in the cytoplasm. Persistent dsDNA in neurons is an early pathological hallmark of senescence and neurodegenerative diseases including Alzheimer's disease (AD).