Publications by authors named "Xiaolin Yang"

Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of combination scalp acupuncture in treating post-stroke cognitive impairment.

Methods: A comprehensive search was conducted across eight databases: PubMed, Web of Science, Cochrane Database, Embase, CBM, CNKI, WanFang, and VIP, targeting randomized controlled trials (RCTs) published from the inception of these databases until October 24, 2024. The inclusion criteria focused on RCTs that compared scalp acupuncture with conventional treatments as therapeutic interventions for patients suffering from post-stroke cognitive impairment (PSCI).

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Background: The fecal immunochemical test (FIT) has been widely used in colorectal cancer (CRC) screening, yet the practical performance of FIT combined with questionnaire-based risk assessment (QRA) remains undetermined. Moreover, risk factors for distinct CRC precursors identified in screening have been rarely compared.

Methods: This study was based on a population-based CRC screening in China, with 2,120,340 participants completing both FIT and QRA.

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Objective: This study aimed to evaluate the cardiorenal effect of combining sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) when compared with monotherapy of either agent in patients with type 2 diabetes (T2D).

Methods: PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov were systematically searched from inception to June 2024.

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Triterpenoid saponins are crucial natural products widely distributed in various medicinal plants, with Dipsacus asperoides being particularly rich in these compounds. However, the glycosyltransferases responsible for the biosynthesis of α-hederin, one of the primary bioactive secondary metabolites in D. asperoides, have not been elucidated.

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  • * Researchers identified ten new genetic variants (SNPs) linked to fat mass response, with four of them also showing consistent effects in individuals of European descent.
  • * A genetic score derived from these SNPs and other factors explained 40.3% of the variation in fat loss, particularly highlighting that those with lower genetic scores tended to lose more fat, while also identifying key biological pathways involved, such as insulin secretion and fat cell differentiation.
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The aim of this study was to assess the relationship between variant loci significantly associated with sports-related traits in the GWAS Catalog database and sprint/power athlete status, as well as to explore the polygenic profile of elite athletes. Next-generation sequencing and microarray technology were used to genotype samples from 211 elite athletes who had achieved success in national or international competitions in power-based sports and from 522 non-athletes, who were healthy university students with no history of professional sports training. Variant loci collected from databases were extracted after imputation.

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  • This study investigates the genetic factors linked to improved power from resistance training by using Genome-Wide Association Analysis (GWAS) on 193 Han Chinese adults who participated in a 12-week training program.
  • The results showed a significant increase in countermovement jump height, with individual changes varying widely, and identified 38 key genetic markers that correlate with these changes.
  • The predictive model created accounted for 62.6% of the variations in training outcomes, suggesting that both genetic markers and physical traits play a role in how individuals respond to resistance training.
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Rice false smut, caused by , threatens rice production by reducing yields and contaminating grains with harmful ustiloxins. However, studies on resistance genes are scarce. In this study, the resistance level of IR28 (resistant cultivar) to was validated through artificial inoculation.

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Mutations in the epidermal growth factor receptor (EGFR) gene are common driver oncogenes in non-small cell lung cancer (NSCLC). Studies have shown that afatinib is beneficial for NSCLC patients with rare EGFR mutations. However, the effectiveness of tyrosine kinase inhibitors (TKIs) against the G719X (G719A, G719C and G719S) mutation has not been fully established.

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The association between anti-obesity medications (AOMs) as well as their weight-loss effects and cardiovascular outcomes need to be comprehensively investigated. We searched PubMed, Embase, the Cochrane Center Register of Controlled Trials for Studies, and Clinicaltrial.gov website from the inception to April 2024 and included 129 randomized controlled trials (RCTs) of AOMs.

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Diversified crop rotations can help mitigate the negative impacts of increased agricultural intensity on the sustainability of agroecosystems. However, the impact of crop rotation diversity on the complexity of soil microbial association networks and ecological functions is still not well understood. In this study, a 6-year field experiment was conducted to evaluate how six different crop rotations change the composition and network complexity of soil microbial communities, as well as their related ecological functions.

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The significance of small molecule metabolites as biomarkers for disease diagnosis and prognosis is growing increasingly evident, necessitating the development of highly sensitive qualitative and quantitative methods. Herein, multi-chemoselective probes are synthesized and applied for profiling metabolites, including carboxyl, phosphate, hydroxyl, amino, thiol, and carbonyl compounds. This approach seamlessly integrates magnetic solid-phase materials, orthogonal cleavage sites, isotopic tags, and selective coupling sites, minimizes matrix interference, and enhances quantitative accuracy.

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Background: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with the tumor microenvironment (TME) playing a crucial role in its progression. Aggregated autophagy (AA) has been recognized as a factor that exacerbates CRC progression. This study aims to study the relationship between aggregated autophagy and CRC using single-cell sequencing techniques.

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  • Researchers developed a new drug delivery system using hen egg low-density lipoprotein (heLDL) to transport the antibiotic ceftiofur (CEF), creating a formulation called CEF-heLDL that has a stable structure and efficient drug loading.
  • In lab tests, CEF-heLDL effectively entered cells and targeted lysosomes, showing better antibacterial activity, especially against Staphylococcus aureus, compared to the CEF-alone group.
  • The study found that high doses of CEF-heLDL were safe for mice, suggesting that heLDL can be a cost-effective and safe carrier for delivering other antibiotics across cell membranes.
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The field of electrogenerated chemiluminescence (ECL) biosensing has witnessed remarkable growth, emphasizing the need for precise detection of biomarkers. The synthesis approach of peptide-based signal probe with high recognition ability and high ECL efficiency is a significant issue in the ECL biosensing. Here, a heavily labeled signal probe was synthesized for ECL peptide-based biosensing tactic by using a new aldehyde bearing cyclometalated Ir(III) complex ([Ir(bt)(bpy-CHO)PF (bt=2-phenylbenzothiazole, bpy-CHO=4'-methyl-[2,2'-bipyridine]-4-carbaldehyde, denoted as Ir1) as ECL signal reagent and streptavidin (SA) as carrier protein.

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  • The study analyzed how participation in sports during youth affects physical activity levels in adulthood, surveying over 2,500 youths and about 1,000 adults.
  • Three main patterns of sports participation emerged: "organized sports," "unorganized sports," and "low activity," with varying percentages among males and females in each category.
  • Youth involvement in "organized sports" was linked to significantly higher activity levels in adulthood, while "unorganized sports" also contributed positively for females compared to those with low activity levels.
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Predicting drug-target affinity (DTA) is beneficial for accelerating drug discovery. In recent years, graph structure-based deep learning models have garnered significant attention in this field. However, these models typically handle drug or target protein in isolation and only extract the molecular structure information on the drug or protein itself.

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  • - The study aimed to compare the effectiveness of adalimumab versus methotrexate in treating psoriasis, addressing ongoing debates on their efficacy.
  • - A systematic review gathered data from four randomized controlled trials involving 733 psoriasis patients, using various statistical methods to analyze the results.
  • - Findings indicated that adalimumab significantly outperformed methotrexate in improving psoriasis severity and quality of life, with no notable differences in adverse events between the two treatments.
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As one of rare high-value ocotillol (OCT)-type ginsenosides, pseudoginsenoside Rt5 has been identified with significant pharmacological activities. UDP-glycosyltransferases (UGTs) play pivotal roles in catalyzing the transfer of a glycosyl moiety from a donor to an acceptor. In this study, the novel UGT, PjUGT10, was screened from the transcriptome database of Panax japonicus and identified with the enzymatic activity of transferring a glucosyl group on OCT to produce Rt5.

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A bone-inclusive ASTM phantom is proposed to improve the assessment of radiofrequency electromagnetic field (RF-EMF) power deposition near orthopedic device under 1.5 T and 3 T magnetic resonance imaging (MRI).A phantom is created by introducing a cylindrical bone structure inside the American Society for Testing and Materials (ASTM) phantom.

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  • Sodium bicarbonate (NaHCO) ingestion has shown positive effects on performance during high-intensity exercise, but this study focuses on its impact on longer durations, specifically a 40 km time trial for trained cyclists.
  • Fourteen male cyclists ingested NaHCO or a placebo in a controlled experiment, and results indicated that NaHCO not only improved their time by an average of 54 seconds but also enhanced their blood buffering capacity during the trial.
  • The findings suggest that using NaHCO mini-tablets delivered in a carbohydrate hydrogel is an effective strategy for cyclists seeking to boost performance while experiencing minimal gastrointestinal discomfort.
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Signaling pathways are responsible for transmitting information between cells and regulating cell growth, differentiation, and death. Proteins in cells form complexes by interacting with each other through specific structural domains, playing a crucial role in various biological functions and cell signaling pathways. Protein-protein interactions (PPIs) within cell signaling pathways are essential for signal transmission and regulation.

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