Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Primary Prevention Indications: A Prospective Observational Cohort Study.

BACKGROUND International studies have shown that use of a subcutaneous implantable cardioverter defibrillator (S-ICD) could reduce lead-related complications while maintaining adequate defibrillation performance; however, data from the Chinese population or other Asian groups are limited. MATERIAL AND METHODS SCOPE is a prospective, multicenter, observational cohort study. Two hundred patients with primary prevention indication for sudden cardiac death (SCD), who are candidates for S-ICD, will be enrolled.

Facile fabrication of 3D Janus foams of electrospun cellulose nanofibers/rGO for high efficiency solar interface evaporation.

Solar-powered interfacial evaporation is one of the most efficient state-of-the-art technologies for producing clean water via desalination. Herein, we report a novel bio-based nanofibrous foam for high efficiency solar interface evaporation. To this end, a hybrid membrane of cellulose nanofibers/graphene oxide (GO) is first fabricated by electrospinning coupled with in situ layer-by-layer self-assembly technique.

Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: In vivo mechanism revealed by metabolomics (liquid chromatography-mass spectrometry).

Objective: Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated the mechanism underlying its metabolic action. Here, liquid chromatography-mass spectrometry (LC-MS)-based metabolomic techniques were utilized to characterize the in vivo effects of Erchen decoction in achieving reduction of oxidative stress levels and understand the potential metabolic mechanisms of action.

Methods: We constructed a DPDRS animal model using a multifactorial composite modeling approach, and Erchen decoction was administered by gavage.

Facile fabrication of three-dimensional nanofibrous foams of cellulose@g-CN@CuO with superior visible-light photocatalytic performance.

In this work, a unique three-dimensional nanofibrous foam of cellulose@g-CN@CuO was prepared via electrospinning followed by a foaming process. A cellulose solution in DMAc/LiCl containing g-CN and CuSO was applied for electrospinning, while aqueous alkali was used as the coagulation bath. The solidification of electrospun cellulose/g-CN nanofibers would be accompanied with in-situ formation of Cu(OH) nanoparticles.

Mechanically Strong and Electrically Conductive Polyethylene Oxide/Few-Layer Graphene/Cellulose Nanofibrils Nanocomposite Films.

In this work, a cellulose nanofibrils (CNFs)/few-layer graphene (FLG) hybrid is mechanically stripped from bamboo pulp and expanded graphene (EG) using a grinder. This strategy is scalable and environmentally friendly for high-efficiency exfoliation and dispersion of graphene in an aqueous medium. The in situ-generated CNFs play a key role in this process, acting as a "green" dispersant.

One-pot superhydrophilic surface modification of waste polyurethane foams for high-efficiency oil/water separation.

Despite of the fact that polymers have brought tremendous convenience to human life, they have also inevitably caused considerable environmental pollution after their service life. Therefore, a feasible strategy that can effectively recycle waste polymers and endow them with high added value is much desired. Superwetting materials have shown great promise in oily wastewater treatment because of their high oil/water separation efficiency.

Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties.

Electrospun cellulose nanofiber nonwovens have shown promise in wound dressing owing to the highly interconnected pore structure, high hydrophilicity coupled with other coveted characteristics of biodegradability, biocompatibility and renewability. However, electrospun cellulose wound dressings with loaded drugs for better wound healing have been rarely reported. In this study, a novel wound dressing with a high drug loading capacity and sustained drug release properties was successfully fabricated via electropinning of cellulose followed by polyethylenimine (PEI)-functionalization.

Effects of Erchen Decoction on Oxidative Stress-Related Cytochrome P450 Metabolites of Arachidonic Acid in Dyslipidemic Mice with Phlegm-Dampness Retention Syndrome: A Randomized, Controlled Trial on the Correspondence between Prescription and Syndrome.

Phlegm-dampness retention (PDR) syndrome is one of the main syndromes of dyslipidemia. This study investigated the effects of Erchen decoction (ECD) on concentrations of two oxidative stress-related cytochrome P450 (CYP450) metabolites of arachidonic acid-14,15-dihydroxyeicosatrienoic acid (14,15-DHET) and 20-hydroxyeicosatetraenoic acid (20-HETE)-in mice with dyslipidemia and phlegm-dampness retention (PDR) syndrome ( = 5 C57BL/6J mice and  = 30 apolipoprotein E knockout mice). Murine models of the disease and syndrome were established using multifactor stimulation.

Iron-Loaded Carbon Aerogels Derived from Bamboo Cellulose Fibers as Efficient Adsorbents for Cr(VI) Removal.

A unique iron/carbon aerogel (Fe/CA) was prepared via pyrolysis using ferric nitrate and bamboo cellulose fibers as the precursors, which could be used for high-efficiency removal of toxic Cr(VI) from wastewaters. Its composition and crystalline structures were characterized by FTIR, XPS, and XRD. In SEM images, the aerogel was highly porous with abundant interconnected pores, and its carbon-fiber skeleton was evenly covered by iron particles.

Study on the Effect of Macrophages on Vascular Endothelium in Mice With Different TCM Syndromes of Dyslipidemia and its Biological Basis Based on RNA-Seq Technology.

"Treating the same disease with different methods" is a Traditional Chinese medicine (TCM) therapeutic concept suggesting that, while patients may be diagnosed with the same disease, they may also have different syndromes that require distinct drug administrations. This study aimed to identify the differentially expressed genes and related biological processes in dyslipidemia in relation to phlegm-dampness retention (PDR) syndrome and spleen and kidney Yang deficiency (SKYD) syndrome using transcriptomic analysis. Ten ApoE mice were used for the establishment of dyslipidemic disease-syndrome models via multifactor-hybrid modeling, with five in the PDR group and five in the SKYD group.

Acquired long QT syndrome in chronic kidney disease patients.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions contribute to the prolonged QT interval in patients with CKD.

Dysfunctional Cav1.2 channel in Timothy syndrome, from cell to bedside.

Unlabelled: Timothy syndrome is a rare disorder caused by CACNA1C gene mutations and characterized by multi-organ system dysfunctions, including ventricular arrhythmias, syndactyly, dysmorphic facial features, intermittent hypoglycemia, immunodeficiency, developmental delay, and autism. Because of the low morbidity and high mortality at a young age, it remains a huge challenge to establish a diagnosis and treatment system to manage Timothy syndrome patients. Here, we aim to provide a detailed review of Timothy syndrome, discuss the mechanisms underlying dysfunctional Cav1.

A new method to recommend left ventricular lead positions for improved CRT volumetric response and long-term prognosis.

Objectives: Using ECG-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), we sought to develop and validate a new method to recommend left ventricular (LV) lead positions in order to improve volumetric response and long-term prognosis after cardiac resynchronization therapy (CRT).

Methods: Seventy-nine patients received gated SPECT MPI at baseline, and echocardiography at baseline and follow-up. The volumetric response referred to a reduction of ≥ 15% in LV end-systolic volume 6 months after CRT.

Serum metabolomics model and its metabolic characteristics in patients with different syndromes of dyslipidemia based on nuclear magnetic resonance.

Dyslipidemia is known as a common clinical disease that affects the health of millions of people around the world. The treatment of dyslipidemia with traditional Chinese medicine (TCM) is generally based on the accurate identification of disease syndromes. TCM syndromes are judged by traditional four-diagnosis method, which is subjective and fuzzy.

Evaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization.

In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (CRT-P) or with pacing and defibrillator (CRT-D) therapy. One hundred and ninety-six subjects (50%) had dilated cardiomyopathy, 108 (27.6%) had ischemic heart disease and 112 (28.

Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation.

Background: Although atrial fibrillation (AF) is the most common abnormal heart rhythm and its prevalence continues to rise, there is a marked paucity of effective and safe antiarrhythmic drugs for AF. This study was done to test whether combined use of dofetilide and mexiletine exhibits not only a synergistic effect on AF suppression but also a safer profile in drug-induced ventricular proarrhythmias.

Methods And Results: The effects of dofetilide plus mexiletine on atrial effective refractory period (ERP), AF inducibility, QT, and QT-related ventricular arrhythmias were studied using the isolated arterially perfused rabbit atrial and ventricular wedge preparations.

GABAergic Interneurons are Required for Generation of Slow CA1 Oscillation in Rat Hippocampus.

Neuronal oscillations are fundamental to hippocampal function. It has been shown that GABAergic interneurons make an important contribution to hippocampal oscillations, but the underlying mechanism is not well understood. Here, using whole-cell recording in the complete hippocampal formation isolated from rats at postnatal days 14-18, we showed that GABAA receptor-mediated activity enhanced the generation of slow CA1 oscillations.

Association of the hERG mutation with long-QT syndrome type 2, syncope and epilepsy.

Mutations in the human ether‑à‑go‑go‑related gene (hERG) are responsible for long‑QT syndrome (LQTS) type 2 (LQT2). In the present study, a heterozygous missense mutation (A561V) linked to LQT2, syncope and epilepsy was identified in the S5/pore region of the hERG protein. The mutation, A561V, was prepared and subcloned into hERG‑pcDNA3.

Vasostatin-2 inhibits cell proliferation and adhesion in vascular smooth muscle cells, which are associated with the progression of atherosclerosis.

Recently, the serum expression level of vasostatin-2 was found to be reduced and is being studied as an important indicator to assess the presence and severity of coronary artery disease; the functional properties of vasostatin-2 and its relationship with the development of atherosclerosis remains unclear. In this study, we attempted to detect the expression of vasostatin-2 and its impact on human vascular smooth muscle cells (VSMCs). Quantitative real-time PCR (qRT-PCR) and western blot were used to assess the expression level of vasostatin-2 in VSMCs between those from atherosclerosis and disease-free donors; we found that vasostatin-2 was significantly down-regulated in atherosclerosis patient tissues and cell lines.

[Effect of Negative Emotions on Serum Levels of Adrenocorticotropic Hormones and Neuropeptide Y in Hepatitis B Liver Cirrhosis Patients].

Objective: To explore the effect of negative emotions on serum levels of adrenocorticotropic hormone (ACTH) and neuropeptide Y (NYP) in hepatitis B liver cirrhosis (HBLC) patients.

Methods: Totally 617 HBLC patients were assigned to the negative emotion group (415 cases) and the non-negative emotion group (202 cases) judged by negative emotions. Case numbers of various grading Child-Pugh were recorded in the two groups.

Low-dose Exogenous Ouabain Alleviates Cardiac Lipotoxicity Through Suppressing Expression of CD36.

CD36 is a key transporter involved in fatty acid (FA) uptake and contributes to the accumulation of FA in cardiomyocytes. The objective of this study was to investigate the role of ouabain, a glycoside regulator of Na(+)/K(+)-ATPase, in the regulation of CD36 expression and FA accumulation. FATP1 transgenic (Tg) mice with lipotoxic cardiomyopathy displayed significantly increased cardiac CD36 expression and free fatty acid accumulation.

Mexiletine Prevents Recurrent Torsades de Pointes in Acquired Long QT Syndrome Refractory to Conventional Measures.

Objectives: The purpose of this study was to examine the role of mexiletine, a late sodium current (I) blocker, in acute termination of torsades de pointes (TdP) refractory to conventional therapy in acquired long QT syndromes (LQTS).

Background: Long QT interval can predispose to TdP and is therefore associated with significant mortality. Currently, there is no available pharmacotherapy to target directly the ionic basis of most LQTS for the acute termination of TdP.

Intervention Effect of Baduanjin Exercise on the Fatigue State in People with Fatigue-Predominant Subhealth: A Cohort Study.

Objectives: To observe the effect of a Baduanjin exercise intervention on fatigue in people with fatigue-predominant subhealth (FPSH).

Participants: A total of 131 participants were included in this cohort study. Those who met the inclusion criteria were grouped into the Baduanjin cohort (n=64) or the control cohort (n=67).

Statistical analysis of 4 types of neck whiplash injuries based on classical meridian theory.

As one component of the Chinese medicine meridian system, the meridian sinew (Jingjin, (see text), tendino-musculo) is specially described as being for acupuncture treatment of the musculoskeletal system because of its dynamic attributes and tender point correlations. In recent decades, the therapeutic importance of the sinew meridian has become revalued in clinical application. Based on this theory, the authors have established therapeutic strategies of acupuncture treatment in Whiplash-Associated Disorders (WAD) by categorizing four types of neck symptom presentations.