Cationizable transcytosis manganese nano-oxygenator for enhanced chemo-dynamic immunotherapy in deep tumour tissue.

Effective delivery of therapeutic agents for solid tumour treatment is impeded by multiple obstacles, such as aberrant interstitial fluid pressure and high density of the extracellular matrix, which causes impaired penetration to deep avascular tumour tissue that exists in a hypoxic immune cold environment. Only limited tumoricidal effects have been achieved with traditional nanomedicine due to its inefficient penetration and the multiple resistant effects that exist in the tumour microenvironment. Herein, a new chemo-dynamic immunotherapy (CDIT) is proposed based on a transcytosis tumour oxygenator (MnP) with effective chemo-dynamic effects.

Liver Function Biomarkers and Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank.

Background: As the primary organ of metabolism and detoxification, the liver may contribute to the pathogenesis of lung cancer. We aimed to illuminate the intricate link between liver function biomarkers and lung cancer risk, as well as delineate the role of smoking behavior within this association.

Methods: We investigated the associations of seven liver function biomarkers levels (alkaline phosphatase [ALP], alanine transaminase [ALT], total bilirubin [TBIL], albumin [ALB], gamma-glutamyltransferase [GGT], aspartate transaminase [AST], and total protein [TP]) with lung cancer risk across the UK Biobank (N = 337 499) through restricted cubic splines and Cox proportional hazards models.

The Relationship Between Moral Sensitivity, Missed Nursing Care and Moral Distress Among New Nurses: A Cross-Sectional Study.

Unlabelled: Moral sensitivity, missed nursing care and moral distress among healthcare professionals have received considerable attention in recent years. These factors represent important healthcare challenges for new nurses (graduation to 2 years of work experience). However, studies on the relationships among these variables in the context of new nurses in China remain lacking.

The food security risks in the Yangtze River Delta of China associated with water scarcity, grain production, and grain trade.

Grain production consumes a large amount of water and is affected by the degree of water scarcity and participation in the grain trade in various regions. The grain trade has changed the food security risks in regions where grain exports and imports. Therefore, it is crucial to consider regional water scarcity to understand food security risks from the grain trade network.

SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese.

Background: Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.

Methods: A total of 1000 Chinese users of illicit drugs and 9693 healthy controls were enrolled and underwent single nucleotide polymorphism (SNP)-based and haplotype-based association analyses via whole-genome genotyping.

Exploration of the radiosensitivity-related prognostic risk signature in patients with glioma: evidence from microarray data.

Background: Gene expression signatures can be used as prognostic biomarkers in various types of cancers. We aim to develop a gene signature for predicting the response to radiotherapy in glioma patients.

Methods: Radio-sensitive and radio-resistant glioma cell lines (M059J and M059K) were subjected to microarray analysis to screen for differentially expressed mRNAs.

The potential capability of substituting chemical fertilizers with crop straw and human-livestock-poultry manure in areas with different topographic characteristics.

Agricultural production and lifestyle are constrained by topography, causing notable under disparities in the composition, distribution, and environmental benefits of crop straw and human-livestock-poultry manure (CSHLPM) in areas with different topographic characteristics. Under the premise of the international consensus on sustainable development, it has become an objective requirement to improve the use of CSHLPM as fertilizer, and minimize the use of chemical fertilizers. Thus, an investigation was conducted to assess the difference in the quantity and composition of CSHLPM in plain, hill, and mountainous areas, taking Anhui Province of China as a case study, to evaluate the potential contribution of CSHLPM to farmland and identify the environmental benefits.

[Retracted] MicroRNA‑599 targets high‑mobility group AT‑hook 2 to inhibit cell proliferation and invasion in clear cell renal carcinoma.

Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that cell migration and invasion assay data shown in Fig. 5C were strikingly similar to data appearing in different form in other articles by different authors, which have been retracted. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere when it was submitted to , the Editor has decided that this paper should be retracted from the Journal.

Observed causative impact of fine particulate matter on acute upper respiratory disease: a comparative study in two typical cities in China.

Association between fine particulate matter (PM) and respiratory health has attracted great concern in China. Substantial epidemiological evidences confirm the correlational relationship between PM and respiratory disease in many Chinese cities. However, the causative impact of PM on respiratory disease remains uncertain and comparative analysis is limited.

Feasibility of machine learning methods for predicting hospital emergency room visits for respiratory diseases.

The prediction of hospital emergency room visits (ERV) for respiratory diseases after the outbreak of PM is of great importance in terms of public health, medical resource allocation, and policy decision support. Recently, the machine learning methods bring promising solutions for ERV prediction in view of their powerful ability of short-term forecasting, while their performances still exist unknown. Therefore, we aim to check the feasibility of machine learning methods for ERV prediction of respiratory diseases.

Public Emotions and Rumors Spread During the COVID-19 Epidemic in China: Web-Based Correlation Study.

Background: Various online rumors have led to inappropriate behaviors among the public in response to the COVID-19 epidemic in China. These rumors adversely affect people's physical and mental health. Therefore, a better understanding of the relationship between public emotions and rumors during the epidemic may help generate useful strategies for guiding public emotions and dispelling rumors.

Effect of total flavones of Clematis filamentosa Dunn on the oxLDL-induced injury of vascular smooth muscle cells by regulating miR-455-5p.

This experiment was conducted to investigate whether total flavones of Clematis filamentosa Dunn affect the inflammatory response and apoptosis of vascular smooth muscle cells induced by oxidized low-density lipoprotein (oxLDL) by regulating microRNA-455-5p (miR-455-5p). 50 mg/mL oxLDL was performed to stimulate the injury of vascular smooth muscle cells, and the total flavones of Clematis filamentosa Dunn were added at concentrations of 75, 150, and 300 μg/mL. The expressions of inflammatory factors IL-1β and TNF-α were analyzed by ELISA, the apoptosis was evaluated by flow cytometry, the expression of Bcl-2 and Bax was determined by western blot, and the real-time fluorescence quantitative PCR (qRT-PCR) was applied to detect miR-455-5p expression.

Graph-based generative models for de Novo drug design.

The discovery of new chemical entities is a crucial part of drug discovery, which requires the lead compounds to have desired properties to be pharmaceutically active. De novo drug design aims to generate and optimize novel ligands for macromolecular targets from scratch. The development of graph-based deep generative neural networks has provided a new method.

MicroRNA-599 targets high-mobility group AT-hook 2 to inhibit cell proliferation and invasion in clear cell renal carcinoma.

Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development of clear cell renal cell carcinoma (ccRCC) through their participation in a number of critical biological processes. Therefore, an in‑depth investigation into miRNAs and their biological roles within ccRCC may provide useful insights and lead to the identification of novel therapeutic methods for patients with ccRCC. miRNA‑599 (miR‑599) serves critical roles in different types of human cancer.

The Association between Air Pollution and Population Health Risk for Respiratory Infection: A Case Study of Shenzhen, China.

Nowadays, most of the research on air pollution and its adverse effects on public health in China has focused on megacities and heavily-polluted regions. Fewer studies have focused on cities that are slightly polluted. Shenzhen used to have a favorable air environment, but its air quality has deteriorated gradually as a result of development in recent years.

A decreased micronucleus frequency in human lymphocytes after folate and vitamin B12 intervention: a preliminary study in a Yunnan population.

Background: Micronucleus (MN) is a validated biomarker for DNA damage in peripheral blood lymphocytes (PBL) and is a reflection of the changes of human nutritional status. Folate (FA) and vitamin B(12) are one-carbon metabolism-related micronutrients, which play important roles in maintaining genomic stability.

Objective: To investigate the correcting effects of FA and B(12) intervention on DNA damage in PBL.

Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.

A plasma pharmacochemistry analysis of the bioactive constituents in rat plasma after oral administration of ChanSu was performed. High performance liquid chromatography coupled with the electrospray ionization mass spectrometry techniques of HPLC/ESI-IT-MS/MS and RRLC/ESI-Q-TOF-MS were used for the chemical profiling of samples of dosed plasma, control plasma and ChanSu extract. Comparative analysis of the resulting chemical profiles revealed 20 prototype compounds and 4 metabolites derived from ChanSu as potential bioactive components.