Publications by authors named "Xiaolin Duan"

Understanding the mechanisms behind MYC-driven oncogenic transformation could pave the way for identifying novel drug targets. This study explored the role of CREPT in MYC-induced malignancy by generating MYC-transformed mouse embryonic fibroblasts (MEFs) with conditional CREPT deletion. Our results demonstrated that the loss of CREPT significantly impaired MYC-induced colony formation and cell proliferation, indicating that CREPT is essential for the malignant transformation of MEFs.

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Aerosol acidity (or pH) is one central parameter in determining the health, climate, and ecological effects of aerosols. While it is traditionally assumed that the long-term aerosol pH levels are determined by the relative abundances of atmospheric alkaline to acidic substances (referred to as hereinafter), we observed contrasting pH─ trends at different sites globally, i.e.

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Under China's strict industrial control measures, the reduction of secondary pollutants (O and secondary organic aerosols [SOA]) and precursors (volatile organic compounds [VOCs] and NOx) caused by industrial processes has encountered bottlenecks. In this study, the net O formation rate (Net [O]) in summer and the self-reaction rate between peroxy radicals (Self-Rnxs) in winter are used to characterize the formation potentials of O and SOA, respectively. Assuming that the precursor reduction ratio based on emission inventories is approximately equal to that based on observed concentrations, this study combines emission inventory and observation-based model (OBM) methods to indicate the potential source of secondary pollutants reduction.

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Per- and polyfluoroalkyl substances (PFASs) in high-latitude polar regions and the Tibetan Plateau have received widespread international attention. Here, we measured 18 PFASs and 11 major isomers in the lake water, sediment, and surrounding runoff of Lake Nam Co in 2020. The concentrations of ultrashort-chain trifluoroacetic acid (TFA) and perfluoropropanoic acid (PFPrA) and major isomers of perfluoooctanoic acid (PFOA) and perfluoooctane sulfonate acid (PFOS) in water bodies in high-latitude polar regions and the Tibetan Plateau are reported for the first time.

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Volatile organic compounds (VOCs) play a major role in O formation in urban environments. However, the complexity in the emissions of VOCs and nitrogen oxides (NOx) in industrial cities has made it challenging to identify the key factors influencing O formation. This study used observation-based-model (OBM) to analyze O sensitivities to VOCs and NOx during summer in a typical industrial city in China.

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The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity and integration of imaging and therapeutic functions. The multifaceted nature of inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, and biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class of materials that have emerged in this context are peptide-functionalized inorganic oxide nanomaterials (PFIONs), which have demonstrated excellent performance in multifunctional imaging and therapy, making them potential candidates for advancing solid tumor diagnosis and treatment.

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Driven by precursor emissions, meteorological conditions, and other factors, atmospheric ozone (O) has become the main pollutant affecting urban air quality in summer. The current deductive models driven by physical and chemical mechanisms require a large number of parameters for the analysis of O pollution, and the calculation timeliness is poor. The data-driven inductive models are efficient but have problems such as poor explanation.

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Hourly observations in northern China city of Taiyuan were performed to compare secondary inorganic aerosol (SIA) reaction mechanisms, and emission effects on SIA during the pre-lock and COVID-19 lock days. Emission control implemented and meteorological conditions during lock days both caused beneficial impact on air quality. NO showed the highest decrease ratio of -49.

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Despite the adoption of air quality control measures, the influence of regional transport on volatile organic compounds (VOCs) pollution has gradually increased in Beijing. In this study, the whole observation period (September 24 to December 12, 2020) was divided into heating period and non-heating period to explore the impact of changing VOCs sources in different observation periods, and also classified into "Type-N" and "Type-S" periods both in non-heating period and heating period to explore the impact of regional transport from the northern and southern regions of sampling site, respectively. The average VOCs concentrations in northern Beijing during observation period were 22.

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Article Synopsis
  • The study analyzed PM concentration data from 11 cities in Shanxi Province over four years, revealing an increase from 2015 to 2017 followed by a decrease from 2018 to 2019, with seasonal variations influenced by winter and summer.
  • Significant periodic changes in PM levels were identified, with energy consumption and industrial structure as long-term influencing factors, while short-term variations were largely affected by atmospheric conditions unique to different cities.
  • The findings suggest that addressing industrial and energy structures is essential for effectively managing PM levels in the region.
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Ammonia is essential for the generation of secondary inorganic aerosols (SIA) in particulate matter, which affects severely the air quality in north China. In this study, PM sampling was conducted as well as gaseous pollutant concentration and meteorological parameters were measured from November 2017 to January 2018. PM concentration was highest in the industrial site (94.

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Objective: Several epidemiological studies have been performed to evaluate the association of fruit and vegetable consumption with risk of the metabolic syndrome (MetS), but the results remain controversial. Thus, we conducted a systematic meta-analysis to assess the associations of fruit or/and vegetable consumption with risk of MetS, separately.

Design: We searched PubMed, EMBASE and Web of Science databases up to July 2017 for relevant available articles.

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Epidemiology studies have been carried out to investigate the association between alcohol consumption and the risk of gallstone disease, but the results remain controversial. We carried out a meta-analysis to quantitatively summarize the evidences from observational studies on alcohol consumption and the risk of gallstone disease. Eligible studies published in English were identified by searching PubMed, Web of Science, and Embase databases.

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CREPT (cell cycle-related and expression elevated protein in tumor)/RPRD1B (regulation of nuclear pre-mRNA domain-containing protein 1B), highly expressed during tumorigenesis, was shown to enhance transcription of CCND1 and to promote cell proliferation by interacting with RNA polymerase II. However, which signaling pathway is involved in CREPT-mediated activation of gene transcription remains unclear. In this study, we reveal that CREPT participates in transcription of the Wnt/β-catenin signaling activated genes through the β-catenin and the TCF4 complex.

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Transforming growth factor-β (TGF-β) signaling plays an important role in regulation of a wide variety of cellular processes. Canonical TGF-β signaling is mediated by Smads which were further regulated by several factors. We previously reported that E3 ubiquitin ligase CHIP (carboxyl terminus of Hsc70-interacting protein, also named Stub1) controlled the sensitivity of TGF-β signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

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