New insight for SS‑31 in treating diabetic cardiomyopathy: Activation of mitoGPX4 and alleviation of mitochondria‑dependent ferroptosis.

SS‑31 is a mitochondria‑targeting antioxidant that exhibits promising therapeutic potential for various diseases; however, its protective effect on diabetic cardiomyopathy (DCM) remains to be elucidated. At present, SS‑31 is considered not only to mitigate cardiolipin oxidative damage, but also to alleviate ferroptosis. The present study aimed to explore SS‑31 as a potential therapeutic strategy for improving DCM by alleviating mitochondria‑dependent ferroptosis.

Learning Autonomous Navigation in Unmapped and Unknown Environments.

Autonomous decision-making is a hallmark of intelligent mobile robots and an essential element of autonomous navigation. The challenge is to enable mobile robots to complete autonomous navigation tasks in environments with mapless or low-precision maps, relying solely on low-precision sensors. To address this, we have proposed an innovative autonomous navigation algorithm called PEEMEF-DARC.

Genomic nursing science revealed the prolyl 4-hydroxylase subunit alpha 2 as a significant biomarker involved in osteosarcoma.

Backgrounds: This study aims to explore the clinical value of P4HA2 (prolyl 4-hydroxylase subunit alpha 2) in Osteosarcoma (OSC), and assess its potential to provide directions and clues for the practice of precision nursing.

Methods: The GSE73166 and GSE16088 datasets were used to explore the P4HA2 expression in OSC. We then used the clinical data of patients obtaining from TARGET database to assess the prognostic value of P4HA2 in OSC.

ConTIG: Continuous representation learning on temporal interaction graphs.

Representation learning on temporal interaction graphs (TIG) aims to model complex networks with the dynamic evolution of interactions on a wide range of web and social graph applications. However, most existing works on TIG either (a) rely on discretely updated node embeddings merely when an interaction occurs that fail to capture the continuous evolution of embedding trajectories of nodes, or (b) overlook the rich temporal patterns hidden in the ever-changing graph data that presumably lead to sub-optimal models. In this paper, we propose a two-module framework named ConTIG, a novel representation learning method on TIG that captures the continuous dynamic evolution of node embedding trajectories.

Sustainable management of campus fallen leaves through low-temperature pyrolysis and application in Pb immobilization.

Realizing campus sustainability requires the environmental-friendly and economical treatment of tremendous fallen leaves. Producing fallen leaf biochar at a low temperature is a candidate approach. In this study, six common types of fallen leaves on the campus were pyrolyzed at 300 °C.

Optimization of extraction process of 15 bioactive compounds from Qing Fei Yi Huo tablets using response surface methodology.

Qing Fei Yi Huo tablets (QFYHT) can relieve the clinical symptoms of acute bronchitis, and is widely prescribed in China. However, the quality standard of QFTHT lacks quantitative assessment. Therefore, it is crucial to develop an effective method for the extraction and analyses of its bioactive components.

Enhancing lead immobilization by biochar: Creation of "surface barrier" via bio-treatment.

The long-term effectiveness of heavy metal immobilization is always a concern. This study proposes a completely novel approach to enhance the stability of heavy metals by combined biochar and microbial induced carbonate precipitation (MICP) technology, to create a "surface barrier" of CaCO layer on biochar after lead (Pb) immobilization. Aqueous sorption studies and chemical and micro-structure tests were used to verify the feasibility.

Variation in quality of the different prepared formulation granules of rhubarb was evaluated by quantitative analysis of multicomponents with single marker.

Rhei Radix et Rhizoma formula granule (RRFG) , Winy Rhei Radix et Rhizoma formula granule(WRFG) and Rhubarb charcoal formula granules (RCFG) are the three most popular and effective formula granules of rhubarb in China and anthraquinone components are their main active ingredients. In order to discuss the difference in anthraquinone components of these three drugs, a simultaneous quantitative analysis method of multicomponents by single-marker (QAMS) was developed. Emodin was chosed as the internal reference standard, the relative correction factors (RCFs) of aloe-emodin, rhein, chrysophanol and physcion were established and the contents of the four components were calculated based on the RCFs, respectively.

Effect of tumor-associated macrophages on lncRNA PURPL/miR-363/PDZD2 axis in osteosarcoma cells.

Tumor-associated macrophages (TAMs) are known to participate in osteosarcoma (OS) progression. As demonstrated in our previous research, miR-363 played a tumor inhibitory effect in OS cells via lowering the PDZ domain containing 2 (PDZD2) expression. The regulatory roles of TAMs on miR-363/PDZD2 and the internal mechanism relating to long noncoding RNA p53 upregulated regulator of P53 levels (lncRNA PURPL) are examined in this study.

A Cost-Effective Method for Preparing Robust and Conductive Superhydrophobic Coatings Based on Asphalt.

The wide application of superhydrophobic materials is mainly hindered by the poor mechanical robustness and complicated preparation method. To overcome these problems, we tried to make a combination of hierarchical and self-similar structure by the means of a simple spraying method. By adding nanofiller (carbon nanotube) and microfiller (graphite powder and expanded graphite), the hierarchical structure was constructed.

A Fenton-like system of biochar loading Fe-Al layered double hydroxides (FeAl-LDH@BC) / HO for phenol removal.

FeAl-layered double hydroxide (FeAl-LDH) supported by char was synthesized using the hydrothermal method in order to activate hydrogen peroxide (HO) to degrade phenol. The effects of char type, char synthesis amount, and several important parameters on the degradation were investigated. In addition, the physicochemical properties of FeAl-LDH@BC were revealed by instruments including the transmission electron microscope (TEM), X-ray diffraction (XRD), and Fourier-transform infrared (FT-IR).

Removal of lead by rice husk biochars produced at different temperatures and implications for their environmental utilizations.

Rice husk is a common agricultural waste. The utilization of rice husk biochar depends on the characteristics of biochar and its interaction mechanisms with heavy metals. In the present study, rice husk biochars at three different temperatures 300, 500, and 700 °C were produced (RH300, RH500, and RH700).

Risk evaluation of biochars produced from Cd-contaminated rice straw and optimization of its production for Cd removal.

Based on the "waste-treat-waste" concept, biochars were produced from cadmium (Cd)-contaminated rice straw (CRSBs) at 300, 500, and 700 °C (CRSB300, CRSB500, and CRSB700). The risks of the Cd remaining in CRSBs were evaluated and the optimal biochar pyrolysis temperature for Cd removal was investigated. It was observed that 41% of the total Cd in the raw rice straw was exchangeable, which may pose significant risks to crops and humans.

miR-206 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targetting glutaminase.

Osteoblast-mediated bone formation is a complex process involving various pathways and regulatory factors, including cytokines, growth factors, and hormones. Investigating the regulatory mechanisms behind osteoblast differentiation is important for bone regeneration therapy. miRNAs are known as important regulators, not only in a variety of cellular processes, but also in the pathogenesis of bone diseases.

Effect of production temperature on lead removal mechanisms by rice straw biochars.

Production temperature significantly affects biochar properties and consequently the removal mechanisms of heavy metals. In this study, rice straw biochars were produced at 300, 500 and 700 °C (RSB300, RSB500 and RSB700). The influence of production temperature on the adsorption characteristics and removal mechanisms of lead on this set of rice straw biochars were investigated by batch adsorption tests, micro-structural analyses and sequential metal extractions.

A Novel Grid SINS/DVL Integrated Navigation Algorithm for Marine Application.

Integrated navigation algorithms under the grid frame have been proposed based on the Kalman filter (KF) to solve the problem of navigation in some special regions. However, in the existing study of grid strapdown inertial navigation system (SINS)/Doppler velocity log (DVL) integrated navigation algorithms, the Earth models of the filter dynamic model and the SINS mechanization are not unified. Besides, traditional integrated systems with the KF based correction scheme are susceptible to measurement errors, which would decrease the accuracy and robustness of the system.

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis.

Background: The efficacy of ifosfamide-based chemotherapy in the treatment of osteosarcoma has been investigated; however, results are inconsistent. Therefore, we reviewed the relevant studies and conducted a meta-analysis to assess the efficacy of ifosfamide-based chemotherapy in patients with osteosarcoma.

Methods: A systematic literature search on PubMed, Embase, and Web of Science databases was performed.

An improved ant colony optimization approach for optimization of process planning.

Computer-aided process planning (CAPP) is an important interface between computer-aided design (CAD) and computer-aided manufacturing (CAM) in computer-integrated manufacturing environments (CIMs). In this paper, process planning problem is described based on a weighted graph, and an ant colony optimization (ACO) approach is improved to deal with it effectively. The weighted graph consists of nodes, directed arcs, and undirected arcs, which denote operations, precedence constraints among operation, and the possible visited path among operations, respectively.

A graph-based ant colony optimization approach for process planning.

The complex process planning problem is modeled as a combinatorial optimization problem with constraints in this paper. An ant colony optimization (ACO) approach has been developed to deal with process planning problem by simultaneously considering activities such as sequencing operations, selecting manufacturing resources, and determining setup plans to achieve the optimal process plan. A weighted directed graph is conducted to describe the operations, precedence constraints between operations, and the possible visited path between operation nodes.

[Study progress of allograt bone combined with growth factors transplantation].

Bone transplantation is widely used in orthopaedics, and allograft bone transplantation is being more and more emphasized. In this article, the allograft bone combined with growth factors transplantation for repairing bone defects were reviewed. Moreover, the way to compound many growth factors and other material is the tendency of allogenic bone grafting, which enhance the opportunity of success in bone transplanting.