Clinical Characteristics and Prognoses of Mucormycosis in Four Children.

Background: Mucormycosis is a fatal invasive fungal infection that commonly affects immunocompromised children. The aim of our study was to investigate the clinical manifestations, treatments, and prognosis of pediatric patients with mucormycosis.

Methods: We conducted a retrospective search in Shenzhen Children's Hospital from July 2013 to July 2023 for all patients with mucormycosis.

Cancer-associated Fibroblast-promoted LncRNA Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma.

Purpose: Our study aimed to investigate whether CAF (cancer-associated fibroblasts) were involved in long noncoding RNAs (lncRNA)-regulated radioresponse in esophageal squamous cell carcinoma (ESCC). By use of lncRNAs PCR array, 38 lncRNAs were screened in esophageal cancer cells and in normal esophageal epithelial cells Het-1A. LncRNA DNM3OS was detected in tumor tissues of patients with ESCC and in matched normal esophageal epithelial tissues by qRT-PCR analysis and hybridization assay.

The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells.

UHMWPE granule could induce macrophages and inflammatory responses in interfacial tissues, which eliminated the wear debris of UHMWPE component and further induced dissolution of the surrounding bone, leading aseptic loosening. However, the mechanism of synovial cells, especially fibroblast-like synovial (FLS) cells response to UHMWPE, remains unknown. Herein we choose FLS cells as research object.

Robust, Self-Healing, and Multistimuli-Responsive Supergelator for the Visual Recognition and Separation of Short-Chain Cycloalkanes and Alkanes.

In this study, we show that a novel kind of cholesterol-based gelator NPS containing pyridyl and naphthalimide units can visually discriminate cyclohexane/cyclopentane from hexane/pentane on the basis of distinct optical differences in the gel platform, which is not observed in solution. The effect of congeneric solvents on the gel properties, such as morphology, rheology, and stimuli-responsive properties, is also studied. Intriguingly, NPS can form self-supporting, self-healing, fluorescent, and highly visible transmittance gels in cyclohexane that can selectively and visually respond to picric acid.

Tunable multicolor emissions in a monocomponent gel system by varying the solvent, temperature and fluoride anion.

The facile tuning of the fluorescent properties of organogels is highly desirable for optical switches, light-emitting diodes, chemosensors and bioprobes. The design of organic molecules with multiple emission colors but only one molecular platform remains challenging. Herein, a new cholesterol-based organogelator N1 containing D-A pairs (salicylaldehyde and naphthalimide units) was designed.

Stereoselectively synthesis and structural confirmation of dehydrodipeptides with dehydrobutyrine.

Most of polypeptides containing α,β-dehydroamino acids have important biological activity, so exploration of synthetic method has practical significance. In this paper, dipeptides were prepared from l-threonine by protecting of c-terminal allyl acetate, and condensing reaction with a series of N-Boc amino acid. Then, treatment of dipeptides obtained with DMAP, (Boc)2O and tetramethylguanidine in the acetonitrile occured β-elimination reaction to yield stereoselectively dehydrodipeptides.

Tunable and Switchable Control of Luminescence through Multiple Physical Stimulations in Aggregation-Based Monocomponent Systems.

This report describes how the luminescence of naphthalimide could be tuned by various physical stimuli, including heat, sonication, and grinding. Herein, instant and switchable control of color and fluorescent emissions has been achieved by the sonication-triggered gelation of an organic liquid with naphthalimide-based organogelators (N3-N7). Green emissive suspensions of the gelators in organic liquids are transformed into orange emissive gels upon brief irradiation with ultrasound with an emission wavelength red-shift of approximately 60 nm and fluorescence intensity quenching by a factor of 20, which can subsequently be reversed by heating.

Visual Recognition of Aliphatic and Aromatic Amines Using a Fluorescent Gel: Application of a Sonication-Triggered Organogel.

A naphthalimide-based fluorescent gelator (N1) containing an alkenyl group has been designed and characterized. This material is able to gelate alcohols via a precipitate-to-gel transformation when triggered with ultrasound for less than 2 min (S-gel). The gelation process in n-propanol was studied by means of absorption, fluorescence, and IR spectra, scanning electron microscopy (SEM) images, and X-ray diffraction patterns.

Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity.

A series of open-chain analogs of cyclic peptides was designed and synthesized using sansalvamide A as a model compound. All compounds exhibited low antitumor activity. Furthermore, the evaluation of their inhibitory potency toward IMPDH, SHP2, ACHE, proteasome, MAGL, and cathepsin B showed that all of the compounds were potent against protein tyrosine phosphatase Shp2.

An "off-on" fluorescent and colorimetric probe bearing fluorescein moiety for Mg(2+) and Ca(2+) via a controlled supramolecular approach.

In the present work, a new kind of fluorescein-based chemosensor L was designed and synthesized to selectively recognize Ca(2+) or Mg(2+) over other competing ions. The chemosensor showed "off-on" fluorescent and color changes upon the addition of Ca(2+) and Mg(2+). The dynamic binding events with the formation of 1:1(L/M) and 1:2(L/M) complexes were examined.

Intramolecular proton transfer through the adjoining π-conjugated system in Shiff base: application for colorimetric sensing of fluoride anion.

In this paper, a new kind of phenol-based chemsensor L2 comprised of a Schiff base and azo groups was rationally designed and synthesized. It could selectively recognize fluoride anion among tested anions such as F(-), AcO(-), H2PO4(-), Cl(-), Br(-), and I(-) with obvious color changes from yellow to fuchsia. The intramolecular PT (proton transfer) in L1 and L2 was responsible for the sensing ability, which was certified by the (1)H NMR and Uv-vis experiments.

Enhanced reduction of C-N multiple bonds using sodium borohydride and an amorphous nickel catalyst.

Amorphous nickel powder (Ni(0)) was utilised as a catalyst under mild, aqueous, basic conditions for enhancing the sodium borohydride-mediated reduction of C-N multiple bonds such as oximes, imines, hydrazones and nitriles to produce the corresponding amines in good to excellent yields.

Stereoselective synthesis and rearrangement-fragmentation of arylidene N-alkoxydiketopiperazines.

A stereoselective synthesis of arylidene N-alkoxydiketopiperazines via oxime-ether formation and intramolecular acylation is described, followed by an acid-catalysed rearrangement-fragmentation to give novel diketopiperazine hemiaminal derivatives with useful bioactivity against certain tumour cell lines.

(Anthracen-9-ylmeth-yl)benzyl-ammonium chloride.

In the title compound, C(22)H(20)N(+)·Cl(-), the anthracene system makes a dihedral angle of 72.65 (4)° with the benzene ring. The C-N-C-C torsion angles in the chain connecting the benzene ring and anthracene system are 52.

Dimethyl 2-(2,4,6-trimethoxy-benz-yl)malonate.

In the title compound, C(15)H(20)O(7), the benzene ring makes dihedral angles of 69.17 (5) and 80.81 (4)° with the two side chains of malonate.

Dimethyl 2-(2-quinolylmeth-yl)malonate.

In the title compound, C(15)H(15)NO(4), the quinoline ring system and one of the malonate side chains are essentially coplanar (r.m.s.

2,5-Bis[2-(2-methoxy-ethoxy)phen-yl]-1,3,4-oxadiazole.

In the title compound, C(20)H(22)N(2)O(5), the central 1,3,4-oxadiazole ring is essentially planar [r.m.s.

(E)-1,5-Dimethyl-4-[3-(4-nitro-benz-yloxy)benzyl-ideneamino]-2-phenyl-1H-pyrazol-3(2H)-one.

In the title compound, C(25)H(22)N(4)O(4), the central benzene ring, makes dihedral angles of 74.35 (6), 17.01 (8) and 62.

(E)-4-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino-meth-yl]phenyl 4-bromo-benzene-sulfonate.

In the title compound, C(24)H(20)BrN(3)O(4)S, the central benzene ring makes dihedral angles of 17.13 (13), 39.83 (13) and 58.

(E)-N'-[2-(4-Chloro-3-nitro-phenyl-sulfon-yloxy)-3-methoxy-benzyl-idene]isonicotinohydrazide acetic acid tetra-solvate.

In the title compound, C(20)H(15)ClN(4)O(7)S·4CH(3)COOH, the central o-vanillin group makes dihedral angles of 9.50 (11) and 42.86 (7)°, respectively, with its attached pyridine and nitro-benzene rings.