Effect of High-Temperature Deformation Twinning on the Work Hardening Behavior of Fe-38Mn Alloy during Hot Shear-Compression Deformation.

The effect of high-temperature deformation twinning on the work hardening behaviors of Fe-38Mn alloy during hot shear-compression deformation was investigated. The discovery of micro-shear bands and deformation twinning is significant for continuous work hardening, and this represents an important step toward gaining a complete understanding of the effect of deformation twinning on work hardening behaviors. Deformation twinning is widely acknowledged to accommodate plastic strain under cold deformation, even under severe plastic deformation.

Associations of modern initial antiretroviral therapy regimens with all-cause mortality in people living with HIV in resource-limited settings: a retrospective multicenter cohort study in China.

Despite the proven virological advantages, there remains some controversy regarding whether first-line integrase strand transfer inhibitors (INSTIs)-based antiretroviral therapy (ART) contributes to reducing mortality of people living with HIV (PLHIV) in clinical practice. Here we report a retrospective study comparing all-cause mortality among PLHIV in China who were on different initial ART regimens (nevirapine, efavirenz, dolutegravir, lopinavir, and others [including darunavir, raltegravie, elvitegravir and rilpivirine]) between 2017 and 2019. A total of 41,018 individuals were included across China, representing 21.

Immediate and long-term outcomes after treat-all among people living with HIV in China: an interrupted time series analysis.

Background: In 2003, China implemented free antiretroviral therapy (ART) for people living with HIV (PLHIV), establishing an eligibility threshold of CD4 < 200 cells/μl. Subsequently, the entry criteria were revised in 2012 (eligibility threshold: CD4 ≤ 350 cells/μl), 2014 (CD4 ≤ 500 cells/μl), and 2016 (treat-all). However, the impact of treat-all policy on HIV care and treatment indicators in China is unknown.

Chromosome 1q21 gain is an adverse prognostic factor for newly diagnosed multiple myeloma patients treated with bortezomib-based regimens.

Chromosome 1q21 aberration is one of the most common cytogenetic abnormalities in multiple myeloma, and is considered an important prognostic factor. The present study analyzed the clinical relevance and prognostic impact of 1q21 gain in 194 patients with newly diagnosed multiple myeloma treated with bortezomib-based regimens. 1q21 gain was detected in 45.

The impact of COVID-19 non-pharmaceutical interventions on HIV care continuum in China: An interrupted time series analysis.

Background: China implemented strict non-pharmaceutical interventions to contain COVID-19 at the early stage. We aimed to evaluate the impact of COVID-19 on HIV care continuum in China.

Methods: Aggregated data on HIV care continuum between 1 January 2017 and 31 December 2020 were collected from centers for disease control and prevention at different levels and major infectious disease hospitals in various regions in China.

Facile fabrication of Ag@C@C8 nanoparticles as a SERS substrate and their environmental applications.

After preparing carbon-coated silver (Ag@C) nanoparticles by a one-step hydrothermal synthesis method, the surface of the nanoparticles was modified with chlorodimethyloctylsilane (C8) to generate C8 functionalized Ag@C@C8 nanoparticles. The Ag@C@C8 nanoparticles were then employed as a substrate for surface enhancement Raman scattering (SERS). The high sensitivity, good uniformity, and long stability Raman signals for both probe dyes (rhodamine 6G and crystal violet) and a real sample (malachite green) in water demonstrated good performance of the as-synthesised Ag@C@C8 nanoparticles.

Splenic infarction due to complex infection in an HIV-infected patient with immune reconstitution failure: a case report.

Splenic infarction is extremely rare in human immunodeficiency virus-infected populations. We report a rare case of splenic infarction involving complex infection in a patient with acquired immune deficiency syndrome with immune reconstitution failure. A young man was initially admitted with cryptococcus meningitis and found to be infected with human immunodeficiency virus.

Facile synthesis of Ag@C@Ag hybrid nanoparticles as SERS substrate.

Ag@C core-shell nanoparticles (NPs) were first prepared by a low-temperature heating-stirring method and subsequently modified with polyethyleneimine (PEI) at different concentrations. Finally, Ag@C@Ag hybrid NPs were prepared by a simple self-assembly procedure, and 24-nm Ag NPs were attached onto the surface of the initially fabricated PEI-modified Ag@C NPs via interaction between the NH groups of PEI and Ag. The results demonstrated that rhodamine 6G (R6G) could be detected at a concentration as low as 10 M using the Ag@C@Ag NPs as a substrate.

Feiyanning Formula Induces Apoptosis of Lung Adenocarcinoma Cells by Activating the Mitochondrial Pathway.

Feiyanning formula (FYN) is a traditional Chinese medicine (TCM) prescription used for more than 20 years in the treatment of lung cancer. FYN is composed of , , , , , and , All of them have been proved to have anti-tumor effect. In this study, we used the TCM network pharmacological analysis to perform the collection of compound and disease target, the prediction of compound target and biological signal and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.

Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial.

Purpose: Donafenib, a novel multikinase inhibitor and a deuterated sorafenib derivative, has shown efficacy in phase Ia and Ib hepatocellular carcinoma (HCC) studies. This study compared the efficacy and safety of donafenib versus sorafenib as first-line therapy for advanced HCC.

Patients And Methods: This open-label, randomized, parallel-controlled, multicenter phase II-III trial enrolled patients with unresectable or metastatic HCC, a Child-Pugh score ≤ 7, and no prior systemic therapy from 37 sites across China.

Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis.

: To investigate the acceptability of human papillomavirus (HPV) vaccination among men who have sex with men (MSM) and its associated factors. : We searched studies written in English in PubMed, EMBASE, and Web of Science with no geographical or time restrictions. We evaluated the quality of the included literature.

Risk factors and prognosis analysis of acute myeloid leukemia in children.

Purpose: To explore the efficacy and related prognostic factors of acute myeloid leukemia (AML) in children except acute promyelocytic leukemia (APL).

Methods: The clinical data of 89 non-APL children with AML treated in our hospital were retrospectively analyzed. The remission status was analyzed after chemotherapy, the long-term survival was evaluated using the Kaplan-Meier method, and the influencing factors for the prognosis were detected using univariate and multivariate Cox regression analyses.

Invasive fungal infection caused by geotrichum capitatum in patients with acute lymphoblastic leukemia: a case study and literature review.

Geotrichum capitatum infection has a very low incidence rate with atypical clinical symptoms, making diagnosis difficult, and it has a poor prognosis. The incidence is even more rare in China. This paper reports the first case of infection caused by G.

[Inducing effect of chidamide on apoptosis of multiple myeloma cells and its relerance to DNA damage response].

Objective: This study was aimed to explore the effect of a novel histone deacetylase inhibitor Chidamide on apoptosis of human multiple myeloma(MM) cells and its relevance to DNA damage response(DDR).

Methods: The cell proliferation was detected by MTT method, apoptosis and cell cycle distribution were analyzed by flow cytometry, the expression levels of targeted proteins were detected by Western blot, the DNA damage response was blocked by ATM kinase inhibitor KU-55933.

Results: Chidamide inhibited RPMI 8226 cell proliferation in dose- and time-dependent manner and its IC50 values of 24,48,72 h were 9.

[Progress in TcpC research].

TcpC is a homolog of the Toll/interleukin-1 receptor (TIR) domain and is secreted by uropathogenic E. coli strain CFT073. TcpC can bind to MyD88, hereby exerting inhibitory effects on macrophages.