Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications.

The liver, functioning as an endocrine organ, secretes a variety of substances that influence the activities of other body organs. Conversely, molecules generated by organs such as bone, the gut, and adipose tissue can also impact liver function. Accumulating evidence suggests bidirectional communication between the liver and other organs.

Cross-subject EEG-based Motor Imagery Recognition for Patient's Rehabilitation.

Motor imagery (MI), a kind of psychological representation without actual action, has garnered increasing attention in rehabilitation. However, the inherent differences between patients and healthy persons hinder rehabilitation by reducing the accuracy of cross-subject MI recognition. Although unsupervised domain adaptation (UDA) methods have mitigated individual differences, they still suffer from challenges in terms of selecting confusing source domains and accurately classifying MI samples at the boundary.

Modulating N-Heterocyclic Microenvironment in β-Ketoenamine Covalent Organic Frameworks to Boost Overall Photosynthesis of HO.

Covalent Organic Frameworks (COFs) have emerged as promising platforms for photocatalytic synthesis of hydrogen peroxide (HO) due to their tunable chemical compositions and efficient catalytic functionalities. Inspired by the role of the microenvironment in enzyme catalysis, this study introduces various N-heterocyclic species into β-ketoenamine COFs (N-COFs, where N represents the number of nitrogen atoms in the N-heterocycle) to regulate the microenvironment around catalytic sites on acceptor-donor-acceptor (A-D-A) COFs foroverall HO photosynthesis in pure water. The N-COFs exhibit distinct HO photosynthetic rates following the number of nitrogen atoms sequence of N-COF > N-COF > N-COF > N-COF, with N-COF with triazine structure showing the highest HO generation rate (4881 µmol h g) and the decent solar-to-chemical conversion (SCC) efficiency (0.

Virtual reality-induced motion sickness under autonomous vehicle driving conditions: EEG-based recognition and ANOVA analysis of various driving modes.

Motion sickness induced by autonomous driving technology poses a new challenge to the emerging sustainable transportation systems. This study investigates the association between motion sickness in autonomous driving and electroencephalogram (EEG) signals under three laboratory-based simulated scenarios: manual driving, resting, and autonomous driving. EEG data were recorded from participants in each mode, alongside the collection of motion sickness symptoms through questionnaires.

Development and validation of risk-predicting model for oral frailty in older adults patients with stroke.

Objective: This study aimed to construct a nomogram predicting oral frailty risk in Older adults patients with stroke.

Design: A cross-sectional study.

Methods: We selected 664 hospitalised older adults patients with stroke in a tertiary hospital from January 2023 to March 2024.

Preparation of p-type FeO nanoarray and its performance as photocathode for photoelectrochemical water splitting.

Photoelectrochemical (PEC) water splitting has the potential to convert solar energy into chemical energy, emerging as a promising alternative to fossil fuel combustion. In PEC systems, p-type semiconductors are particularly noteworthy for their ability to directly produce hydrogen. In this work, FeO with p-type semiconductor properties grown directly on the conductive glass substrate were successfully synthesized through a simple one-step hydrothermal method.

Saturated fatty acids as guest compounds in the annealing of high-amylose starch: Insights into fatty acid chain length and structural conformation.

This study explores the effect of fatty acid chain length in regulating the structural changes and physicochemical properties of high-amylose maize starch (HAMS) induced by annealing with fatty acid solution (AFAS). AFAS was found to effectively regulate the conformation of amylose molecular chains within starch granules. Annealing with fatty acids of shorter chain length, such as lauric acid, promoted the formation of both double and single helices within HAMS granules.

Perceptions of science, science communication, and climate change attitudes in 68 countries - the TISP dataset.

Science is integral to society because it can inform individual, government, corporate, and civil society decision-making on issues such as public health, new technologies or climate change. Yet, public distrust and populist sentiment challenge the relationship between science and society. To help researchers analyse the science-society nexus across different geographical and cultural contexts, we undertook a cross-sectional population survey resulting in a dataset of 71,922 participants in 68 countries.

Liver-Secreted Extracellular Vesicles Promote Cirrhosis-Associated Skeletal Muscle Injury Through mtDNA-cGAS/STING Axis.

Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic muscle inflammation plays a pivotal role in its pathologenesis. However, the detailed mechanism through which injured liver tissues mediate skeletal muscle inflammatory injury remains elusive. Here, it is reported that injured hepatocytes might secrete mtDNA-enriched extracellular vesicles (EVs) to trigger skeletal muscle inflammation by activating the cGAS-STING pathway.

Spatial Organization of Macrophages in CTL-Rich Hepatocellular Carcinoma Influences CTL Antitumor Activity.

Despite the pivotal role of CTLs in antitumor immunity, a substantial proportion of CTL-rich patients with hepatocellular carcinoma (HCC) experience early relapse or immunotherapy resistance. However, spatial immune variations impacting the heterogeneous clinical outcomes of CTL-rich HCCs remain poorly understood. In this study, we compared the single-cell and spatial landscapes of 20 CTL-rich HCCs with distinct prognoses using multiplexed in situ staining and validated the prognostic value of myeloid spatial patterns in a cohort of 386 patients.

Hydrophilic/hydrophobic heterojunctions for enhanced photocatalytic hydrogen evolution via gas release dynamics.

Covalent-organic frameworks (COFs), characterized by their exceptional light absorption and ordered architecture, have emerged as potential candidates for photocatalytic hydrogen production. In this work, we discovered that the incorporation of fluorine into the sub-nanocavity of azine-linked COF (TF-COF) not only augments its hydrophobicity but also strengthens the interaction between Pt cocatalysts and COFs. In an effort to enhance photocatalytic water splitting efficiency, we integrated the hydrophobic TF-COF with the hydrophilic carbon nitride (CN) to construct a hydrophilic/hydrophobic heterojunction (CTF-x heterojunction).

Hypothermic oxygenated perfusion inhibits CLIP1-mediated TIRAP ubiquitination via TFPI2 to reduce ischemia‒reperfusion injury of the fatty liver.

The use of fatty livers in liver transplantation has emerged as a crucial strategy to expand the pool of donor livers; however, fatty livers are more sensitive to ischemia‒reperfusion injury (IRI). Excessive congenital inflammatory responses are crucial in IRI. Hypothermic oxygenated perfusion (HOPE) is a novel organ preservation technique that may improve marginal donor liver quality by reducing the inflammatory response.

Relationships between emotional state, sleep disturbance and health-related quality of life in patients with axial spondyloarthritis.

Background: Axial spondyloarthritis (ax-SpA) is an autoinflammatory disease affecting multiple organs. While emphasizing the treatment of chronic diseases, it has been found that the prevalence of mental disorders and insomnia in patients is also increasing. We investigated mood status, sleep quality and the health-related quality of life (HRQoL) in these patients.

Control of interlayer friction in two-dimensional ferromagnetic CrBr.

Two-dimensional (2D) magnetic materials may offer new opportunities in the field of lubrication at the nanoscale. It is essential to investigate the interfacial properties, particularly magnetic coupling, at the interfaces of 2D magnetic materials from the point of view of friction. In the present study, we investigated the tribological and interfacial properties at the interface of bilayer CrBr by performing first-principles calculations.

USP13 overexpression in BMSCs enhances anti-apoptotic ability and guards against methylprednisolone-induced osteonecrosis in rats.

Methylprednisolone (MPS) use is linked to increased cases of osteonecrosis of the femoral head (ONFH). Bone marrow mesenchymal stem cells (BMSCs) have shown potential for treating MPS-induced ONFH, but their effectiveness is limited by high apoptosis rates post-transplantation. We developed a pretreatment strategy for BMSCs to improve their viability.

The role of macrophage-derived exosomes in noncancer liver diseases: From intercellular crosstalk to clinical potential.

Chronic liver disease has a substantial global prevalence and mortality rate. Macrophages, pivotal cells in innate immunity, exhibit remarkable heterogeneity and plasticity and play a considerable role in maintaining organ homeostasis, modulating inflammatory responses, and influencing disease progression in the liver. Exosomes, which can serve as conduits for intercellular communication, biomarkers, and therapeutic targets for a spectrum of diseases, have recently garnered increasing attention recently.

Promoting oxygen electrode reaction kinetics in photo-assisted Li-O batteries through heterostructure design and built-in electric field construction.

Li-O batteries (LOBs) boast an exceptionally high theoretical energy density; however, the slow kinetics of the oxygen electrode reaction have been a significant hurdle in their advancement and practical application. In this study, a composite of bismuth oxyhalide heterojunction incorporated with metal-organic frameworks (MOFs) was engineered on carbon cloth (Zr-MOF/BiOIBr/CC) as an efficient bifunctional catalyst to enhance the oxygen electrode reaction in photo-assisted LOBs. Compared to Zr-MOF/CC, Zr-MOF/BiOIBr/CC significantly expands the light absorption spectrum of the catalyst.

Expression of AtNF-YB1 activates early flowering, showing potential in breeding hybrid rice.

The nuclear factor Y (NF-Y) has been shown to be involved in plant growth and development in response to various environmental signals. However, the integration of these mechanisms into breeding practices for new cultivars has not been extensively investigated. In this study, the Arabidopsis gene AtNF-YB1 was introduced into rice, including inbred Kasalath and the hybrids Jinfeng × Chenghui 727 and Jinfeng × Chuanhui 907.

The effect of salidroside on the bone and cartilage properties in broilers.

Leg disorders frequently occur in fast-growing broiler chickens, constituting severe health and welfare problems. Although salidroside (SAL) promotes osteogenesis and inhibits apoptosis of chondrocytes in rats, it remains to be determined whether SAL can effectively improve bone growth in broilers. The present study was designed to investigate the effects of dietary SAL supplementation on bone and cartilage characteristics in broiler chickens.