An overview of characteristic factors of biochar as a soil improvement tool in rice growth- A review.

Biochar is a growing tool for bioremediation and soil improvement applications. Researchers are focusing on biochar due to its efficacy, eco-friendly composition, and cost-effective solutions to a variety of environmental issues. In recent times biochar has been used in enhancing the soil, increasing nutrient content, and sequestering carbon in paddy cultivation soils.

Unraveling the combined toxicity and removal mechanisms of fluoxetine and sertraline co-contaminants by the freshwater microalga Chlorella pyrenoidosa.

Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (FLX) and sertraline (SER), are among the most widely detected pharmaceuticals in aquatic environments, and they usually occur as mixtures. However, little is known about the combined toxicity of SSRI mixtures to microalgae and the associated removal mechanisms. This study investigated the combined toxicity of FLX and SER to the growth, photosynthetic activity, and antioxidant system of Chlorella pyrenoidosa and their removal mechanisms.

Swertia bimaculata moderated liver damage in mice by regulating intestine microbiota.

Swertia bimaculata (SB) is a medicinal herb in China having an array of therapeutic and biological properties. This study aimed to explore the attenuating effect of SB on carbon tetrachloride (CCl) induced hepato-toxicity by regulation of gut microbiome in ICR mice. For this purpose, CCl was injected intraperitoneally in different mice groups (B, C, D and E) every 4th day for a period of 47 days.

Precise Modeling of Thermal and Strain Rate Effect on the Hardening Behavior of SiC/Al Composite.

Temperature and strain rate have significant effects on the mechanical behavior of SiC/Al 2009 composites. This research aimed to precisely model the thermal and strain rate effect on the strain hardening behavior of SiC/Al composite using the artificial neural network (ANN). The mechanical behavior of SiC/Al 2009 composites in the temperature range of 298-623 K under the strain rate of 0.

Effects of Strength and Distribution of SiC on the Mechanical Properties of SiCp/Al Composites.

In this paper, considering the strength and geometric discrete distribution characteristics of composite reinforcement, by introducing the discrete distribution function of reinforcement, the secondary development of ABAQUS is realized by using the Python language, the parametric automatic generation method of representative volume elements of particle-reinforced composites is established, and the tensile properties of silicon carbide particle-reinforced aluminum matrix composites are analyzed. The effects of particle strength, particle volume fraction, and particle random distribution on the mechanical properties of SiCp/Al composites are studied. The results show that the random distribution of particles and the change in particle strength have no obvious influence on the stress-strain relationship before the beginning of material damage, but have a great influence on the damage stage, maximum strength, and corresponding failure strain.

circAMOTL1L Suppresses Renal Cell Carcinoma Growth by Modulating the miR-92a-2-5p/KLLN Pathway.

Accumulating evidence indicates that the dysregulation of circular RNAs (circRNAs) contributes to tumor progression; however, the regulatory functions of circRNAs in renal cell carcinoma (RCC) remain largely unknown. In this study, the function and underlying mechanism of circAMOTL1L in RCC progression were explored. qRT-PCR showed the downregulation of circAMOTL1L in RCC tissues and cell lines.

LINC00937 suppresses keloid fibroblast proliferation and extracellular matrix deposition by targeting the miR-28-5p/MC1R axis.

Long noncoding RNAs (lncRNAs) are the most recently discovered class of noncoding RNAs. LncRNAs play a crucial role in multiple disorders. However, the role and mechanism of action of lncRNAs in keloids remain unclear.

JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination.

Purpose: Chimeric antigen receptor (CAR)-T cells have shown to play a vital role in anti-tumor functions in hematological malignancies, but have poor efficacy in solid tumors. To improve the activation and proliferation of CAR-T cell in solid tumors, we constructed an enhanced CAR-T cells to increase the survival of esophageal cancer.

Materials And Methods: To construct enhanced CAR-T cells, we chose MUC1 as the target of CAR-T cells.

Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation.

Clinical studies have proven that ultraviolet B (UVB) based phototherapy can induce perifollicular and marginal repigmentation patterns in the skin of vitiligo patients. It is, however, difficult to conceive how melanocytes can easily exit from their tightly interconnected epidermal microenvironment to re‑enter a different location in the skin to establish a new network with neighboring keratinocytes. While it is known that matrix metalloprotease 9 (MMP9) is involved in the degradation of the extracellular matrix in physiological or pathological processes, little is known about whether MMP9 affects melanocyte migration in vitiligo repigmentation.

Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer.

Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer.

Materials And Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed.

[Effect of swimming exercise on MEK and ERK1 phosphorylation level in adipose tissue of insulin resistance rats].

Objective: To investigate the effect of chronic and acute swimming exercise intervention on the mitogen-activated extracellular signal-regulated kinase(MEK) and extracellular signal-regulated kinase 1(ERK1) phosphorylation level in adipose tissues of obesityinduced insulin resistance rats.

Methods: A total of 100 SD rats were randomly divided into control group(n=10) fed with normal diet and high-fat diet group(n=90) fed with high fat diet. After 8 weeks, one third rats(n=30) with upper weight in high-fat diet group were selected and randomly divided into high-fat diet sedentary group(n=10), chronic exercise group(n=10) and acute exercise group(n=10).

miR-9 regulates melanocytes adhesion and migration during vitiligo repigmentation induced by UVB treatment.

The decreased adhesion ability of melanocytes to the neighboring keratinocytes prompts melanocytes to lose from the epidermis, comprising the critical step in vitiligo pathogenesis. The repigmentation process involves the migration of melanocytes to the lesional area. This study aims to investigate the role and mechanism of microRNA (miR)-9 in the adhesion and migration of melanocytes during vitiligo repigmentation induced by UVB treatment.

Autologous cytokine-induced killer cell immunotherapy may improve overall survival in advanced malignant melanoma patients.

Aims: Our study was conducted to explore the efficacy of autologous cytokine-induced killer (CIK) cells in patients with advanced malignant melanoma. Materials & Methods: Here we reviewed 113 stage IV malignant melanoma patients among which 68 patients received CIK cell immunotherapy alone, while 45 patients accepted CIK cell therapy combined with chemotherapy. Results: We found that the median survival time in CIK cell group was longer than the combined therapy group (21 vs 15 months, p = 0.

Effects of huangqi and bear bile on recurrent parotitis in children: a new clinical approach.

Objective: To evaluate the pharmacological effects of traditional Chinese medicine, bear bile capsule and Huangqi granule, on recurrent parotitis in children.

Methods: In this prospective, controlled, and randomized study, a total of 151 young children were divided into three groups: Group A included massaging the children's parotid region and melting vitamin C in their mouth daily; Group B included swallowing bear bile capsule and Huangqi granule daily; and Group C included massages and vitamin C as prescribed in Group A, and traditional Chinese medicine as prescribed in Group B. Children were treated individually for one month and then a follow-up study was conducted for 1 to 3.

Preparation of Pt/{PDDA-GN/PSS-GN}n multilayer films and their electrocatalytic activity regarding methanol oxidation.

The stable aqueous dispersion solutions of polymer-modified graphene were prepared by reduction with hydrazine hydrate in situ from exfoliated graphite oxides in the presence of poly (diallyldimethylammonium chloride) (PDDA) and poly(sodium 4-styrenesulfonate) (PSS), respectively. The multilayer films consisting of PDDA-GN and PSS-GN were fabricated on the substrate by layer-by-layer self-assembly technique and characterized by ultraviolet-visible spectroscopy (UV-vis). The multilayer films were used as a novel catalyst support for electrodeposition of Pt nanoparticle clusters in situ.

A review of the most economically important poisonous plants to the livestock industry on temperate grasslands of China.

The majority of the literature on poisonous plant species in China is published in Chinese and not available to the majority of interested researchers and grassland managers in other countries. Therefore, a review of the Chinese literature was conducted to summarize the occurrence of poisonous plant species on temperate grasslands in China. We reviewed the literature to obtain general information on poisonous species but focus on locoweeds (Astragalus and Oxytropis spp.

Operating condition influences on PCDD/Fs emissions from sinter pot tests with hot flue gas recycling.

This study was designed to clarify the influence of operating conditions on the formation and emissions of polychlorinated-p-dibenzodioxins and dibenzofurans (PCDD/Fs) from a sintering process with hot flue gas recycling. A pilot scale sinter pot with simulated flue gas recycling was developed, and four key operational parameters, including temperature, oxygen content of the simulated waste flue gas, the coke rate of the sintering mixture, and the quicklime quality, were selected for exploring PCDD/Fs formation. The results showed that the temperature of the recycled flue gas had a major affect on PCDD/Fs formation, and a high temperature could significantly increase their formation during sintering.

[Hemodynamic characteristics of chronic congestive heart failure model in awake Beagle dogs].

Objective: To characterize the hemodynamic changes of chronic congestive heart failure(CHF) model induced by rapid right ventricular pacing after myocardial infarction in awake Beagle dogs.

Methods: Five healthy adult male Beagle dogs were prepared for surgery. After the probes for measurement and the pacing leads were implanted, the left anterior descending artery was ligated during the surgery to induce myocardial infarction in the anterior wall of the left ventricle close to the apex.

Clinical and genetic mapping of X chromosome in the X-linked dominant inherited Alport's syndrome.

To study the hereditary mode and clinical characteristics and detect mutations of gene COL4A5 encoding type IV collagen a5 chain among family members of an X-linked dominant inherited Alport's syndrome (AS) family of China, we studied all of 38 family members of whom 2 volunteers underwent renal biopsy. Genomic DNA from all members of the AS family was characterized. All of 51 exons of COL4A5 gene were amplified by polymerase chain reaction (PCR) with the primers synthesized according to the published flanking intervening sequences.

[Effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy].

Objective: To study the effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy by cDNA microarray.

Method: The mice with diabetic nephropathy were fed A. mongholicus and normal saline respectively.