Correlation analysis of the impact of juvenile on gut microbiota and transcriptome in mice.

Unlabelled: remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms.

Long noncoding RNA GAS5 inhibits LX-2 cells activation by suppressing NF-κB signalling through regulation of the miR-433-3p/TLR10 axis.

Background: Liver fibrosis is a common disease that can lead to hepatic failure.

Aims: Our aims were to reveal the role of GAS5 in the regulation of liver fibrosis.

Methods: LX-2 human hepatic satellite cells (HSCs) were cultured and activated using TGF-β1 treatment.

Novel indolo-sophoridinic scaffold as Topo I inhibitors: Design, synthesis and biological evaluation as anticancer agents.

Based on the mechanism of action, novel scaffolds as Topo I inhibitors bearing indole and sophoridinine were designed. Preliminary docking study revealed that some molecules among the designed series possessed promising Topo I inhibitor properties. Subsequently, thirty new compounds were synthesized and characterized by H NMR, C NMR, and Mass spectral analyses.

[Macroscopic and microscopic identification of Zhuang medicine Tetrastigma planicaule].

Objective: To study the macroscopic and microscopic characteristics of Zhuang medicine Tetrastigma planicaule.

Methods: Macroscopic and microscopic identification were studied.

Results: The microscopic characteristics were significant.

[Pharmacognosy identification of Embelia parviflora].

Objective: To study the morphological character and microscopic identification of Embelia parviflora.

Methods: Researches on the morphological character and microscopic identification of roots and stems of Embelia parviflora were carried on respectively.

Results: Significant microscopic characteristics of Embelia parviflora were confirmed.