Rab1A-Mediated Exosomal Sorting of miR-200c Enhances Breast Cancer Lung Metastasis.

Background: Recent therapeutic approaches have improved survival rate for women with breast cancer, but the survival rate for metastatic breast cancer is still low. Exosomes released by various cells are involved in all steps of breast cancer development.

Methods: We established the multimodal imaging report expression in breast cancer cells with lentivirus vectors pGluc and pBirA to investigate the secreted exosomes.

Lactobacillus rhamnosus GG alleviates colitis caused by chemotherapy via biofilm formation.

Background And Aim: Severe colitis is a common side effect of chemotherapy in cancer patients. In this study, we attempted to enhance the viability of probiotics in a gastric acid environment and improve the colitis induced by dextran sulfate sodium (DSS) and docetaxel.

Methods: We purified Lactobacillus from yogurt and estimated their growth at pH 6.

Unsupervised Classification of Polarimetric SAR Image Based on Geodesic Distance and Non-Gaussian Distribution Feature.

Polarimetric synthetic aperture radar (PolSAR) image classification plays a significant role in PolSAR image interpretation. This letter presents a novel unsupervised classification method for PolSAR images based on the geodesic distance and K-Wishart distribution. The geodesic distance is obtained between the Kennaugh matrices of the observed target and canonical targets, and it is further utilized to define scattering similarity.

High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance.

High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin resistant after being administered exosomes isolated from the feces of obese mice fed a HFD or from patients with type II diabetes.

Research on Turning Motion Targets and Velocity Estimation in High Resolution Spaceborne SAR.

The development of high resolution SAR makes the influence of moving target more prominent, which results in defocusing and other unexplained phenomena. This paper focuses on the research of imaging signatures and velocity estimation of turning motion targets. In this paper, the turning motion is regarded as the straight line motion of continuous change of moving direction.

Analysis of the Azimuth Ambiguity and Imaging Area Restriction for Circular SAR Based on the Back-Projection Algorithm.

Circular synthetic aperture radar (CSAR) has a 360° observation capability on the central observation scenario. A typical way to process CSAR imaging is to cut data into small sub-apertures because most targets are only coherent at a very small observation angle. There are many sub-aperture imaging methods after development in recent years.

Tumor-derived nanovesicles promote lung distribution of the therapeutic nanovector through repression of Kupffer cell-mediated phagocytosis.

Tumor-derived nanovesicles have been widely used as a biomarker or therapeutic target in various tumor types. However, these nanovesicles have limited use in therapy due to the risk of advancing tumor development. : Exosome-like nanovesicles (ENVs) were developed from metastatic breast cancer 4T1 cells-derived exosomes.

An Improved Imaging Algorithm for High-Resolution Spotlight SAR with Continuous PRI Variation Based on Modified Sinc Interpolation.

This paper focuses on an improved imaging algorithm for spotlight synthetic aperture radar (SAR) with continuous Pulse Repetition Interval (PRI) variation in extremely high-resolution. Conventional SAR systems are limited in that a wide swath cannot be achieved with a high azimuth resolution in the meantime. This limitation can be overcome by Pulse Repetition Frequency (PRF) variation in a SAR system.

An Improved BAQ Encoding and Decoding Method for Improving the Quantized SNR of SAR Raw Data.

When the original echo data of SAR are saturated for quantization, the performance of the commonly used block adaptive quantization (BAQ) algorithm will be degraded, which will degrade the imaging quality. This article proposes an improved Llody-Max codec method, which only needs to change the codec look-up table to get better quantization performance when the original echo is saturated. The simulation results show that the proposed method can reduce the quantization power loss, improve the echo signal-to-noise ratio (SNR), and reduce the influence of quantization saturation on the scattering mechanism of polarized SAR data, which have good practical application value.

Geo-Positioning Accuracy Improvement of Multi-Mode GF-3 Satellite SAR Imagery Based on Error Sources Analysis.

The GaoFen-3 (GF-3) satellite is the only synthetic aperture radar (SAR) satellite in the High-Resolution Earth Observation System Project, which is the first C-band full-polarization SAR satellite in China. In this paper, we proposed some error sources-based weight strategies to improve the geometric performance of multi-mode GF-3 satellite SAR images without using ground control points (GCPs). To get enough tie points, a robust SAR image registration method and the SAR-features from accelerated segment test (SAR-FAST) method is used to achieve the image registration and tie point extraction.

Decimeter-Level Geolocation Accuracy Updated by a Parametric Tropospheric Model with GF-3.

GaoFen-3 (GF-3) is a multi-polarization C-band synthetic aperture radar (SAR) satellite in China with a resolution of up to 1 m. Up to now, the geolocation accuracy of GF-3 could be improved to 3 m. According to the current study, there still exist meter-level geolocation residuals caused by atmospheric path delay after compensating with a static tropospheric model.

A Range Ambiguity Suppression Processing Method for Spaceborne SAR with Up and Down Chirp Modulation.

Range ambiguity is one of the factors which affect the SAR image quality. Alternately transmitting up and down chirp modulation pulses is one of the methods used to suppress the range ambiguity. However, the defocusing range ambiguous signal can still hold the stronger backscattering intensity than the mainlobe imaging area in some case, which has a severe impact on visual effects and subsequent applications.

The GF-3 SAR Data Processor.

The Gaofen-3 (GF-3) data processor was developed as a workstation-based GF-3 synthetic aperture radar (SAR) data processing system. The processor consists of two vital subsystems of the GF-3 ground segment, which are referred to as data ingesting subsystem (DIS) and product generation subsystem (PGS). The primary purpose of DIS is to record and catalogue GF-3 raw data with a transferring format, and PGS is to produce slant range or geocoded imagery from the signal data.

A Quality Assessment Method Based on Common Distributed Targets for GF-3 Polarimetric SAR Data.

The GaoFen-3 (GF-3) satellite, launched on 10 August 2016, is the first C-band polarimetric synthetic aperture radar (PolSAR) satellite in China. The PolSAR system of GF-3 can collect a significant wealth of information for geophysical research and applications. Being used for related applications, GF-3 PolSAR images must be of good quality.

MiR-30e inhibits tumor growth and chemoresistance via targeting IRS1 in Breast Cancer.

MicroRNA-30e (miR-30e) is downregulated in various tumor types. However, its mechanism in inhibiting tumor growth of breast cancer remains to be elucidated. In this study, we found that miR-30e was significantly downregulated in tumor tissues of breast cancer (BC) patients and cell lines, and overexpression of miR-30e inhibited cell proliferation, migration and invasion.

Unambiguous Imaging of Static Scenes and Moving Targets with the First Chinese Dual-Channel Spaceborne SAR Sensor.

Multichannel synthetic aperture radar (SAR) is a breakthrough given the inherent limitation between high-resolution and wide-swath (HRWS) faced with conventional SAR. This paper aims to obtain unambiguous imaging of static scenes and moving targets with the first Chinese dual-channel spaceborne SAR sensor. We propose an integrated imaging scheme with the dual-channel echoes.

Fast Vessel Detection in Gaofen-3 SAR Images with Ultrafine Strip-Map Mode.

This study aims to detect vessels with lengths ranging from about 70 to 300 m, in Gaofen-3 (GF-3) SAR images with ultrafine strip-map (UFS) mode as fast as possible. Based on the analysis of the characteristics of vessels in GF-3 SAR imagery, an effective vessel detection method is proposed in this paper. Firstly, the iterative constant false alarm rate (CFAR) method is employed to detect the potential ship pixels.

Exosomes from breast cancer cells stimulate proliferation and inhibit apoptosis of CD133+ cancer cells in vitro.

Exosomes are a family of bioactive vesicles that are secreted from various types of cell, including tumor cells. Exosomes derived from breast cancer cells have been demonstrated to perform important functions in tumor progression in vitro and in vivo. However, few studies exist regarding the function of exosomes in CD133+ breast cancer cells.

[Mucoepidermoid carcinoma of nasopharynx: a report of twelve cases].

Background & Objective: Mucoepidermoid carcinoma of nasopharynx, a kind of primary adenocarcinoma of nasopharynx, is rare, and has seldom been reported. This article was to summarize the pathogenesis, clinical features, and treatment outcomes of this disease according to our experiences.

Methods: From Jan.