Hydroalkylation of unactivated olefins with C(sp)─H compounds enabled by NiH-catalyzed radical relay.

The hydroalkylation reaction of olefins with alkanes is a highly desirable synthetic transformation toward the construction of C(sp)─C(sp) bonds. However, such transformation has proven to be challenging for unactivated olefins, particularly when the substrates lack directing groups or acidic C(sp)─H bonds. Here, we address this challenge by merging NiH-catalyzed radical relay strategy with a HAT (hydrogen atom transfer) process.

[Vitiligo Combined With Annular Lichen Planus: A Rare Case Report].

A 36-year-old female patient came to our hospital with the chief complaint of having white patches on her waist for 10-plus years and having new annular plaques appearing on the white patches for 6-plus months. Wood's lamp examination done in the hospital showed a positive result. Histopathology of skin tissue from the edge of the annular swelling on the right waist revealed epidermal hyperkeratosis, wedge-shaped thickening of the granular layer, liquefactive degeneration of the basal cells, and a band-like infiltration of lymphocytes in the superficial dermis.

[Textual Research on Chiding Disease and Matixiang Herb in Da he wai ke (External Medicine of Da He)].

Recorded in Da he wai ke (The External Medicine of Da He) in the Ming dynasty without a corresponding disease title in contemporary scholarly concepts of Traditional Chinese Medicine (TCM), Chiding disease was described as an acute symptomatic disease with inevitable serious conditions of convulsion-like or mania-like behavior, and as a refractory ailment. It was also considered as an alias of Hongsiding (namely the acute lymphangitis) in few ancient books. Matixiang, a Chinese herb for treatment of Chiding, was regarded as a nonsuch drug by Da he wai ke, and was considered as a take-then-cure drug by Chuang yang jing yan quan shu (Compendium for Experience in Sores Diseases).

[Study of the contents of Da He Wai Ke in the Ming Dynasty].

Da He Wai Ke (the Great River External Medicine), an ancient book written by WANG Quan, a folk doctor, who was an apprentice of an unknown mysterious person in the Ming Dynasty. There are two volumes: thirty-six diseases were recorded in volume 1 with a figure for each disease before the descriptive texts, and 72 prescriptions were recorded in volume 2. The current research results about the origin of the contents of this book showed that: (1) contents in volume 1 texts were mainly from Chuang Ke Tong Xuan Lun (Enigmatic Theories for Sores Diseases); (2) there are no any direct clues about the source of the illustrations in volume 1.

[Author, date and editions of Dahe Waike in the Ming Dynasty].

Written by WANG Quan in the Ming Dynasty, Dahe Waike is a TCM surgery monograph with both figures and texts. Barely mentioned in other medical works, the edition published in the 38(th) year of the Wanli Period (1610) and held in the National Archives of Japan (No. 050-0004 I) has been taken as a unique work of great value.